Irreversible phospholipase C (PLC) and phospholipase A2 (PLA2) inhibitor (IC 50 values are 1.5 and 4.7 µM respectively) . Also shown to inhibit calcium channels . Anti-inflammatory and analgesic effects in vivo .
Storage Temp
Store at -20°C,Argon charged,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Manoalide irreversibly inhibits the enzyme phospholipase A2. This inhibition is a key point of study in the enzymatic pathways involved in lipid metabolism and cellular signaling. It is used to probe the role of phospholipase A2 in various cellular processes and to understand the structure-activity relationships governing enzyme-ligand interactions. The compound serves as a biochemical tool in experimental applications, helping to dissect complex biological pathways.
I2418484