Margatoxin, CAS No.145808-47-5, Channel blocker of K v1.1;Channel blocker of K v1.2;Channel blocker of K v1.3;Channel blocker of K v1.7

Features and benefits
    Item Number
    M287709
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    M287709-100μg
    100μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $147.90

    Potent KV1.3 channel blocker

    Basic Description

    Product NameMargatoxin, CAS No.145808-47-5
    SynonymsUNII-6197NL836C | 6197NL836C | HB1083 | Margatoxin | C178H286N52O50S7
    GradeMoligand™
    Specifications & PurityMoligand™
    Biochemical and Physiological MechanismsPotent KV1.3 channel blocker (IC50= 36 pM). Displays no effect at calcium-activated channels. Reduces VEGF-induced transmembrane calcium influxes and nitric oxide production in human endothelial cells.
    SequenceTIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH(Modifications: Disulfide bridge between 7 - 29, 13 - 34, 17 - 36)
    Action TypeCHANNEL BLOCKER
    Mechanism of actionChannel blocker of K v1.1;Channel blocker of K v1.2;Channel blocker of K v1.3;Channel blocker of K v1.7

    Associated Targets(Human)

    KCNA7 Tclin Potassium voltage-gated channel subfamily A member 7 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    KCNA3 Tclin Potassium voltage-gated channel subfamily A member 3 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    KCNA2 Tclin Potassium voltage-gated channel subfamily A member 2 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    KCNA1 Tclin Potassium voltage-gated channel subfamily A member 1 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    Storage TempStore at -20°C
    Shipped InIce chest + Ice pads
    CAS145808-47-5

    Certificates

    Certificate of Analysis(COA)

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    Safety and Hazards(GHS)

    Pictogram(s) GHS06
    Signal Danger
    Hazard Statements

    H301:Toxic if swallowed

    H311:Toxic in contact with skin

    H331:Toxic if inhaled

    H330:Fatal if inhaled

    Precautionary Statements

    P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

    P280:Wear protective gloves/protective clothing/eye protection/face protection.

    P302+P352:IF ON SKIN: wash with plenty of water.

    P321:Specific treatment (see ... on this label).

    P405:Store locked up.

    P501:Dispose of contents/container to ...

    P264:Wash hands [and …] thoroughly after handling.

    P260:Do not breathe dust/fume/gas/mist/vapors/spray.

    P284:[In case of inadequate ventilation] Wear respiratory protection.

    P271:Use only outdoors or in a well-ventilated area.

    P270:Do not eat, drink or smoke when using this product.

    P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P403+P233:Store in a well-ventilated place. Keep container tightly closed.

    P330:Rinse mouth.

    P320:Specific treatment is urgent (see ... on this label).

    P361+P364:Take off immediately all contaminated clothing and wash it before reuse.

    P301+P316:IF SWALLOWED: Get emergency medical help immediately.

    P316:Get emergency medical help immediately.

    Genetic information

    Alternate NamesUNII-6197NL836C | 6197NL836C | HB1083 | Margatoxin | C178H286N52O50S7
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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