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maribavir , Phosphotransferase pUL97 inhibitor, CAS No.176161-24-3, Phosphotransferase pUL97 inhibitor

CAS#: 176161-24-3
Formula: C₁₅H₁₉Cl₂N₃O₄
Molecular Weight: 376.24
PubChem CID: 471161

Item Number

M611736

Grouped product items
SKU	Size	Availability	Price	Qty
M611736-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
M611736-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

Basic Description

Synonyms	5,6-Dichloro-2-(isopropylamino)-1-(beta-L-ribofuranosyl)-1H-benzimidazole \| 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-.BETA.-L-RIBOFURANOSYLBENZIMIDAZOLE \| Maribavir \| maribavirum \| F20066 \| GW-1263 \| cis-3,5-dimethylpiperazine-1-carboxylic acid tert-butyl ester
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Phosphotransferase pUL97 inhibitor

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)

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Homo sapiens (32628 Activities)

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HEK293 (82097 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Human betaherpesvirus 5 (5122 Activities)

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Human alphaherpesvirus 1 (11089 Activities)

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Human betaherpesvirus 6 (53 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

IUPAC Name	(2S,3S,4R,5S)-2-[5,6-dichloro-2-(propan-2-ylamino)benzimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol
INCHI	InChI=1S/C15H19Cl2N3O4/c1-6(2)18-15-19-9-3-7(16)8(17)4-10(9)20(15)14-13(23)12(22)11(5-21)24-14/h3-4,6,11-14,21-23H,5H2,1-2H3,(H,18,19)/t11-,12-,13-,14-/m0/s1
InChi Key	KJFBVJALEQWJBS-XUXIUFHCSA-N
Canonical SMILES	CC(C)NC1=NC2=CC(=C(C=C2N1C3C(C(C(O3)CO)O)O)Cl)Cl
Isomeric SMILES	CC(C)NC1=NC2=CC(=C(C=C2N1[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)O)Cl)Cl
PubChem CID	471161
Molecular Weight	376.24

PubChem CID

CAS Registry No.

ChEMBL Ligand

DrugBank Ligand

References

1. Biron KK, Harvey RJ, Chamberlain SC, Good SS, Smith 3rd AA, Davis MG, Talarico CL, Miller WH, Ferris R, Dornsife RE et al.. (2002) Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action.. Antimicrob Agents Chemother, 46 (8): (2365-72). [PMID:12121906] [10.1021/op500134e]
2. Kang C. (2022) Maribavir: First Approval.. Drugs, 82 (3): (335-340). [PMID:35147913] [10.1021/op500134e]

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maribavir , Phosphotransferase pUL97 inhibitor, CAS No.176161-24-3, Phosphotransferase pUL97 inhibitor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

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References

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