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Marimastat - 99%, high purity , Matrix metalloproteinase 7 inhibitor, CAS No.154039-60-8, Matrix metalloproteinase 7 inhibitor

Specifications & Purity:  99%
Item Number
M302985
Grouped product items
SKUSizeAvailabilityPrice Qty
M302985-5mg
5mg
In stock
$103.90
M302985-10mg
10mg
In stock
$155.90
M302985-25mg
25mg
In stock
$351.90
M302985-50mg
50mg
In stock
$456.90
M302985-100mg
100mg
In stock
$822.90
M302985-200mg
200mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$1,480.90
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Potent matrix metalloproteinase inhibitor

View related series
MMP1 Inhibitor MMP2 Inhibitor MMP3 Inhibitor MMP7 Inhibitor MMP9 Inhibitor

Basic Description

SynonymsMarimastat|154039-60-8|BB-2516|BB 2516|Marimastat (BB-2516)|BB2516|D5EQV23TDS|(2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide|(2R,3S)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4,3-d
Specifications & Purity99%
Storage TempStore at -20°C
Shipped InDry ice
Action TypeINHIBITOR
Mechanism of actionMatrix metalloproteinase 7 inhibitor

Product Properties

ALogP0.5

Associated Targets

TNF Tclin Tumor necrosis factor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MMP1 Tchem Interstitial collagenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MMP7 Tchem Matrilysin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MMP13 Tchem Collagenase 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MMP14 Tchem Matrix metalloproteinase-14 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MMP9 Tchem Matrix metalloproteinase-9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADAM17 Tchem Disintegrin and metalloproteinase domain-containing protein 17 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MMP3 Tchem Stromelysin-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MMP8 Tchem Neutrophil collagenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488187602
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488187602
IUPAC Name (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide
INCHI InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
InChi Key OCSMOTCMPXTDND-OUAUKWLOSA-N
Canonical SMILES CC(C)CC(C(C(=O)NO)O)C(=O)NC(C(=O)NC)C(C)(C)C
Isomeric SMILES CC(C)C[C@H]([C@@H](C(=O)NO)O)C(=O)N[C@H](C(=O)NC)C(C)(C)C
PubChem CID 119031
Molecular Weight 331.41

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
D23181263Certificate of AnalysisMar 13, 2023 M302985
D23181299Certificate of AnalysisMar 13, 2023 M302985
D23181359Certificate of AnalysisMar 13, 2023 M302985
D23181363Certificate of AnalysisMar 13, 2023 M302985
D23181364Certificate of AnalysisMar 13, 2023 M302985
D23181365Certificate of AnalysisMar 13, 2023 M302985
D23181368Certificate of AnalysisMar 13, 2023 M302985
D23181369Certificate of AnalysisMar 13, 2023 M302985
D23181397Certificate of AnalysisMar 13, 2023 M302985
D23181401Certificate of AnalysisMar 13, 2023 M302985
D23181420Certificate of AnalysisMar 13, 2023 M302985
D23181421Certificate of AnalysisMar 13, 2023 M302985

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Chemical and Physical Properties

SolubilityDMSO: ≥20 mg/mL
Melt Point(°C)148°C

Related Documents

 SDS

 Specification Sheet

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References

1. Steward WP, Thomas AL.  (2000)  Marimastat: the clinical development of a matrix metalloproteinase inhibitor..  Expert Opin Investig Drugs,  9  (12): (2913-22).  [PMID:11093361]
2. Williams HF, Layfield HJ, Vallance T, Patel K, Bicknell AB, Trim SA, Vaiyapuri S.  (2019)  The Urgent Need to Develop Novel Strategies for the Diagnosis and Treatment of Snakebites..  Toxins (Basel),  11  (6): (589-97).  [PMID:31226842]
3. Layfield HJ, Williams HF, Ravishankar D, Mehmi A, Sonavane M, Salim A, Vaiyapuri R, Lakshminarayanan K, Vallance TM, Bicknell AB et al..  (2020)  Repurposing Cancer Drugs Batimastat and Marimastat to Inhibit the Activity of a Group I Metalloprotease from the Venom of the Western Diamondback Rattlesnake, Crotalus atrox..  Toxins (Basel),  12  (5): (589-97).  [PMID:32397419]
4. Rasmussen HS, McCann PP.  (1997)  Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat..  Pharmacol Ther,  75  (1): (69-75).  [PMID:9364582]
5. Minutti CM et al..  (2017)  Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion..  Immunity,  47  (4): (710-722.e6).  [PMID:29045902]

Solution Calculators

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