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Marimastat - 99%, high purity , Matrix metalloproteinase 7 inhibitor, CAS No.154039-60-8, Matrix metalloproteinase 7 inhibitor

Item Number
M302985
Grouped product items
SKUSizeAvailabilityPrice Qty
M302985-5mg
5mg
In stock
$103.90
M302985-10mg
10mg
In stock
$155.90
M302985-25mg
25mg
In stock
$351.90
M302985-50mg
50mg
In stock
$456.90
M302985-100mg
100mg
In stock
$822.90
M302985-200mg
200mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$1,480.90
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Potent matrix metalloproteinase inhibitor

View related series
MMP1 Inhibitor MMP2 Inhibitor MMP3 Inhibitor MMP7 Inhibitor MMP9 Inhibitor

Basic Description

SynonymsButanediamide, N4-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)- | GI 5712 | Q6763659 | (2S,3R)-3-[[(1S)-2,2-Dimethyl-1-(methylcarbamoyl)propyl]carbamoyl]-2-hydroxy-5-methylhexanohydroxamic acid | (2S,3R)-
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsPotent matrix metalloproteinase inhibitor. Broad-spectrum inhibitor of all major MMPs. Prevents or reduces spread and growth of tumors.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionMatrix metalloproteinase 7 inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Properties

ALogP0.5

Associated Targets(Human)

TNF Tclin Tumor necrosis factor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MMP1 Tchem Interstitial collagenase (14 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MMP7 Tchem Matrilysin (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MMP13 Tchem Collagenase 3 (7 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MMP14 Tchem Matrix metalloproteinase-14 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MMP9 Tchem Matrix metalloproteinase-9 (9 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MMP2 Tchem 72 kDa type IV collagenase (13 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADAM17 Tchem Disintegrin and metalloproteinase domain-containing protein 17 (7 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MMP3 Tchem Stromelysin-1 (12 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MMP8 Tchem Neutrophil collagenase (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TNF Tclin TNF-alpha (1897 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP26 Tchem Matrix metalloproteinase 26 (24 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP15 Tchem Matrix metalloproteinase 15 (49 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP16 Tchem Matrix metalloproteinase 16 (81 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP14 Tchem Matrix metalloproteinase 14 (1592 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP12 Tchem Matrix metalloproteinase 12 (1130 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP10 Tchem Matrix metalloproteinase 10 (359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP7 Tchem Matrix metalloproteinase 7 (1073 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADAMTS4 Tchem ADAMTS4 (425 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADAMTS5 Tchem ADAMTS5 (711 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THP-1 (11052 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADAM10 Tchem ADAM10 (375 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP24 Tbio Matrix metalloproteinase-24 (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP25 Tchem Matrix metalloproteinase-25 (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP20 Tbio Matrix metalloproteinase-20 (10 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP13 Tchem Matrix metalloproteinase (1 and 13) (154 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mmp13 Matrix metalloproteinase 13 (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adam17 ADAM17 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp2 Matrix metalloproteinase-2 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dpy-31 Metalloendopeptidase (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488187602
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488187602
IUPAC Name (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide
INCHI InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
InChi Key OCSMOTCMPXTDND-OUAUKWLOSA-N
Canonical SMILES CC(C)CC(C(C(=O)NO)O)C(=O)NC(C(=O)NC)C(C)(C)C
Isomeric SMILES CC(C)C[C@H]([C@@H](C(=O)NO)O)C(=O)N[C@H](C(=O)NC)C(C)(C)C
PubChem CID 119031
Molecular Weight 331.41

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot NumberCertificate TypeDateItem
D23181263Certificate of AnalysisMar 13, 2023 M302985
D23181299Certificate of AnalysisMar 13, 2023 M302985
D23181359Certificate of AnalysisMar 13, 2023 M302985
D23181363Certificate of AnalysisMar 13, 2023 M302985
D23181364Certificate of AnalysisMar 13, 2023 M302985
D23181365Certificate of AnalysisMar 13, 2023 M302985
D23181368Certificate of AnalysisMar 13, 2023 M302985
D23181369Certificate of AnalysisMar 13, 2023 M302985
D23181397Certificate of AnalysisMar 13, 2023 M302985
D23181401Certificate of AnalysisMar 13, 2023 M302985
D23181420Certificate of AnalysisMar 13, 2023 M302985
D23181421Certificate of AnalysisMar 13, 2023 M302985

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Chemical and Physical Properties

SolubilityDMSO: ≥20 mg/mL
Melt Point(°C)148°C

Related Documents

 SDS

 Specification Sheet

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References

1. Steward WP, Thomas AL.  (2000)  Marimastat: the clinical development of a matrix metalloproteinase inhibitor..  Expert Opin Investig Drugs,  9  (12): (2913-22).  [PMID:11093361]
2. Williams HF, Layfield HJ, Vallance T, Patel K, Bicknell AB, Trim SA, Vaiyapuri S.  (2019)  The Urgent Need to Develop Novel Strategies for the Diagnosis and Treatment of Snakebites..  Toxins (Basel),  11  (6): (1755-70).  [PMID:31226842]
3. Layfield HJ, Williams HF, Ravishankar D, Mehmi A, Sonavane M, Salim A, Vaiyapuri R, Lakshminarayanan K, Vallance TM, Bicknell AB et al..  (2020)  Repurposing Cancer Drugs Batimastat and Marimastat to Inhibit the Activity of a Group I Metalloprotease from the Venom of the Western Diamondback Rattlesnake, Crotalus atrox..  Toxins (Basel),  12  (5): (1755-70).  [PMID:32397419]
4. Rasmussen HS, McCann PP.  (1997)  Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat..  Pharmacol Ther,  75  (1): (69-75).  [PMID:9364582]
5. Minutti CM et al..  (2017)  Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion..  Immunity,  47  (4): (710-722.e6).  [PMID:29045902]

Solution Calculators

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