Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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M109802-20mg | 20mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $38.90 |
Synonyms | 1H,5H,10H-DIPYRIDO(2,1-F:3',2',1'-IJ)(1,6)NAPHTHYRIDIN-10-ONE, DODECAHYDRO-, (7AS,13AR,13BR,13CS)- | alpha-Matrine | CS-1601 | N390W430AC | 5-24-02-00301 (Beilstein Handbook Reference) | MATRINE [WHO-DD] | UNII-N390W430AC | a-Matrine | CVE73CZ65H | M2120 |
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Specifications & Purity | analytical standard, ≥98% |
Biochemical and Physiological Mechanisms | Description: |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | analytical standard |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one |
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INCHI | InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1 |
InChi Key | ZSBXGIUJOOQZMP-JLNYLFASSA-N |
Canonical SMILES | C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1 |
Isomeric SMILES | C1C[C@@H]2[C@H]3CCCN4[C@H]3[C@@H](CCC4)CN2C(=O)C1 |
WGK Germany | 3 |
PubChem CID | 91466 |
Molecular Weight | 248.36 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J2225425 | Certificate of Analysis | Jul 04, 2024 | M109802 |
F2315128 | Certificate of Analysis | Jan 12, 2023 | M109802 |
F2315135 | Certificate of Analysis | Jan 12, 2023 | M109802 |
J1519077 | Certificate of Analysis | Feb 17, 2022 | M109802 |
Sensitivity | heat sensitive |
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Specific Rotation[α] | 33 ° (C=1, EtOH) |
Melt Point(°C) | 85°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H302:Harmful if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. |
WGK Germany | 3 |
Merck Index | 5759 |
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1. Fa-Li Zhang, Liu Yang, Wei-Hao He, Ling-Jun Xie, Fei Yang, Ying-Hui Wang, Ai-Guo Huang. (2023) In vivo antibacterial activity of medicinal plant Sophora flavescens against Streptococcus agalactiae infection. JOURNAL OF FISH DISEASES, 46 (9): (977-986). [PMID:37294673] |
2. Mi Wang, Zhenyuan Wang, Jichuan Zhang, Liguo Zhang, Wei Wang, Jingbo Zhan, Ya Liao, Chengyu Wu, Wen Yu, Jiaheng Zhang. (2023) A matrine-based supramolecular ionic salt that enhances the water solubility, transdermal delivery, and bioactivity of salicylic acid. CHEMICAL ENGINEERING JOURNAL, 468 (143480). [PMID:] |
3. Kai Zhou, Hua Chen, Xiao-yu Wang, Yan-mei Xu, Yu-feng Liao, Yuan-yuan Qin, Xue-wan Ge, Ting-ting Zhang, Zhong-lin Fang, Bei-bei Fu, Qing-Zhong Xiao, Feng-qin Zhu, Si-rui Chen, Xue-sheng Liu, Qi-chao Luo, Shan Gao. (2022) Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury. BIOMEDICINE & PHARMACOTHERAPY, 155 (113792). [PMID:36271569] |
4. Jia Liu, Hui Du, Tao Liu, Cheng Chen, Ying Yan, Tianqiang Liu, Lei Liu, Erlong Wang. (2022) Accurate reflection of hepatopancreas antioxidation and detoxification in Procambarus clarkii during virus infection and drug treatment: Reference gene selection, evaluation and expression analysis. AQUACULTURE, 556 (738283). [PMID:] |
5. Chengfei Song, Jinyu Zhao, Ruirui Zheng, Chi Hao, Xizhong Yan. (2022) Chemical composition and bioactivities of thirteen non-host plant essential oils against Plutella xylostella L. (Lepidoptera: Plutellidae). JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, 25 (101881). [PMID:] |
6. Yu Haipeng, Zhu Bolan, Yang Wan, Zhang Qian, Wang Wei, Zhai Weichun, Lu Lixia, Zheng Ying, Dang Zheng, Li Bin, Li Chuyi, Liang Bin, Zhang Jiucong, Yu Xiaohui. (2020) Matrine inhibits proliferation and migration of HepG2 cells by downregulating ERK1/2 signaling pathways. Journal of Cancer Research and Therapeutics, 16 (2): (209). [PMID:32474503] |
7. Quanliang Li, Shuya Zhang, Mingyu Wang, Shouguang Dong, Yan Wang, Song Liu, Tiancheng Lu, Yuqin Fu, Xiuran Wang, Guihong Chen. (2019) Downregulated miR‑21 mediates matrine‑induced apoptosis via the PTEN/Akt signaling pathway in FTC‑133 human follicular thyroid cancer cells. Oncology Letters, 18 (4): (3553-3560). [PMID:31579406] |
8. Zhang Peng, Wang Junqian, Ding Xuanwei, Lin Jun, Jiang Hao, Zhou Hongjun, Lu Yuan. (2019) Exploration of the Tolerance Ability of a Cell-Free Biosynthesis System to Toxic Substances. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 189 (4): (1096-1107). [PMID:31161383] |
9. Wei Zhou, Yikun Liu, Xiaoyan Liao, Zilin Chen. (2019) Capillary electrophoresis-mass spectrometry using robust poly(ether ether ketone) capillary for tolerance to high content of organic solvents. JOURNAL OF CHROMATOGRAPHY A, 1593 (156). [PMID:30718059] |
10. Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, 1568 (123). [PMID:30005943] |
11. Junping Zhang, Yanchun Wang, Wei Zheng. (2017) Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens. MOLECULES, 22 (4): (575). [PMID:28368325] |
12. Yongsheng Yang, Qiumei Dong, Rongheng Li. (2017) Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-induced arthritis by suppressing the activation of the JAK/STAT signaling pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 39 (2): (307-316). [PMID:28035365] |
13. Qing Wang, Ling Tong, Lin Yao, Peng Zhang, Li Xu. (2016) Fingerprinting of traditional Chinese medicines on the C18-Diol mixed-mode column in online or offline two-dimensional liquid chromatography on the single column modes. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 125 (205). [PMID:27031576] |
14. Jun Xiang, Yugang Jiang. (2013) Antiepileptic Potential of Matrine via Regulation the Levels of Gamma-Aminobutyric Acid and Glutamic Acid in the Brain. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 14 (12): (23751-23761). [PMID:24317434] |
15. Juan Zhang, Zilin Chen. (2013) Determination of Matrine and Oxymatrine in Sophora Flavescens by Nonaqueous Capillary Electrophoresis-Electrospray Ionization-Ion Trap-Mass Spectrometry. ANALYTICAL LETTERS, [PMID:] |
16. Fangyuan Zhao, Le Wang, Yanling Liu, Ge Song, Fei Wang, Baoxian Ye. (2012) Determination of Matrine Using a New Voltammetric Sensor Based on L-Cysteine/Graphene Oxide-Chitosan Composite Film Modified Electrode. ELECTROANALYSIS, 24 (3): (691-698). [PMID:] |
17. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu. (2014-12-22) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.. Journal of chromatography. A, 1376 (64-73). [PMID:25528071] |
1. Fa-Li Zhang, Liu Yang, Wei-Hao He, Ling-Jun Xie, Fei Yang, Ying-Hui Wang, Ai-Guo Huang. (2023) In vivo antibacterial activity of medicinal plant Sophora flavescens against Streptococcus agalactiae infection. JOURNAL OF FISH DISEASES, 46 (9): (977-986). [PMID:37294673] |
2. Mi Wang, Zhenyuan Wang, Jichuan Zhang, Liguo Zhang, Wei Wang, Jingbo Zhan, Ya Liao, Chengyu Wu, Wen Yu, Jiaheng Zhang. (2023) A matrine-based supramolecular ionic salt that enhances the water solubility, transdermal delivery, and bioactivity of salicylic acid. CHEMICAL ENGINEERING JOURNAL, 468 (143480). [PMID:] |
3. Kai Zhou, Hua Chen, Xiao-yu Wang, Yan-mei Xu, Yu-feng Liao, Yuan-yuan Qin, Xue-wan Ge, Ting-ting Zhang, Zhong-lin Fang, Bei-bei Fu, Qing-Zhong Xiao, Feng-qin Zhu, Si-rui Chen, Xue-sheng Liu, Qi-chao Luo, Shan Gao. (2022) Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury. BIOMEDICINE & PHARMACOTHERAPY, 155 (113792). [PMID:36271569] |
4. Jia Liu, Hui Du, Tao Liu, Cheng Chen, Ying Yan, Tianqiang Liu, Lei Liu, Erlong Wang. (2022) Accurate reflection of hepatopancreas antioxidation and detoxification in Procambarus clarkii during virus infection and drug treatment: Reference gene selection, evaluation and expression analysis. AQUACULTURE, 556 (738283). [PMID:] |
5. Chengfei Song, Jinyu Zhao, Ruirui Zheng, Chi Hao, Xizhong Yan. (2022) Chemical composition and bioactivities of thirteen non-host plant essential oils against Plutella xylostella L. (Lepidoptera: Plutellidae). JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, 25 (101881). [PMID:] |
6. Yu Haipeng, Zhu Bolan, Yang Wan, Zhang Qian, Wang Wei, Zhai Weichun, Lu Lixia, Zheng Ying, Dang Zheng, Li Bin, Li Chuyi, Liang Bin, Zhang Jiucong, Yu Xiaohui. (2020) Matrine inhibits proliferation and migration of HepG2 cells by downregulating ERK1/2 signaling pathways. Journal of Cancer Research and Therapeutics, 16 (2): (209). [PMID:32474503] |
7. Quanliang Li, Shuya Zhang, Mingyu Wang, Shouguang Dong, Yan Wang, Song Liu, Tiancheng Lu, Yuqin Fu, Xiuran Wang, Guihong Chen. (2019) Downregulated miR‑21 mediates matrine‑induced apoptosis via the PTEN/Akt signaling pathway in FTC‑133 human follicular thyroid cancer cells. Oncology Letters, 18 (4): (3553-3560). [PMID:31579406] |
8. Zhang Peng, Wang Junqian, Ding Xuanwei, Lin Jun, Jiang Hao, Zhou Hongjun, Lu Yuan. (2019) Exploration of the Tolerance Ability of a Cell-Free Biosynthesis System to Toxic Substances. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 189 (4): (1096-1107). [PMID:31161383] |
9. Wei Zhou, Yikun Liu, Xiaoyan Liao, Zilin Chen. (2019) Capillary electrophoresis-mass spectrometry using robust poly(ether ether ketone) capillary for tolerance to high content of organic solvents. JOURNAL OF CHROMATOGRAPHY A, 1593 (156). [PMID:30718059] |
10. Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, 1568 (123). [PMID:30005943] |
11. Junping Zhang, Yanchun Wang, Wei Zheng. (2017) Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens. MOLECULES, 22 (4): (575). [PMID:28368325] |
12. Yongsheng Yang, Qiumei Dong, Rongheng Li. (2017) Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-induced arthritis by suppressing the activation of the JAK/STAT signaling pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 39 (2): (307-316). [PMID:28035365] |
13. Qing Wang, Ling Tong, Lin Yao, Peng Zhang, Li Xu. (2016) Fingerprinting of traditional Chinese medicines on the C18-Diol mixed-mode column in online or offline two-dimensional liquid chromatography on the single column modes. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 125 (205). [PMID:27031576] |
14. Jun Xiang, Yugang Jiang. (2013) Antiepileptic Potential of Matrine via Regulation the Levels of Gamma-Aminobutyric Acid and Glutamic Acid in the Brain. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 14 (12): (23751-23761). [PMID:24317434] |
15. Juan Zhang, Zilin Chen. (2013) Determination of Matrine and Oxymatrine in Sophora Flavescens by Nonaqueous Capillary Electrophoresis-Electrospray Ionization-Ion Trap-Mass Spectrometry. ANALYTICAL LETTERS, [PMID:] |
16. Fangyuan Zhao, Le Wang, Yanling Liu, Ge Song, Fei Wang, Baoxian Ye. (2012) Determination of Matrine Using a New Voltammetric Sensor Based on L-Cysteine/Graphene Oxide-Chitosan Composite Film Modified Electrode. ELECTROANALYSIS, 24 (3): (691-698). [PMID:] |
17. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu. (2014-12-22) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.. Journal of chromatography. A, 1376 (64-73). [PMID:25528071] |