| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab170528-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 | |
| Ab170528-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $327.90 | |
| Ab170528-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $717.90 | |
| Ab170528-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,107.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Mavrilimumab (anti-CD116) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CD116, >95%, high purity, Human IgG4SP |
|---|---|
| Synonyms | CD116 antigen | CD116 | CDw116 | colony stimulating factor 2 receptor alpha subunit | colony stimulating factor 2 receptor, alpha, low-affinity(granulocyte-macrophage) | CSF2R | CSF2RA | CSF2RAX | CSF2RAY | CSF2RX | CSF2RY | GM-CSF R alpha | GM-CSF recept |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Host species | Human |
| Specificity | CD116 |
| Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | Antibody of GM-CSF receptor; α subunit |
| Product Description | Mavrilimumab is a monoclonal antibody that binds to the α subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor and blocks downstream intracellular signaling of GM-CSF. GM-CSF may be a mediator of the overactive inflammatory response associated with respiratory failure and death. |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG4SP |
| Light Chain Type | lambdaC2 |
| SDS-PAGE | 28.7 kDa (Light Chain) & 52.9 kDa (Heavy Chain), under reducing conditions; 165.8 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 1085337-57-0 |
Mavrilimumab (anti-CD116) (Ab170528) - Flow Cytometry
Flow Cytometry analysis of U937 cells labelling CD116 (red) with Mavrilimumab (anti-CD116) (Ab170528). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG4SP. Black - Unlabelled control, cells without incubation with primary antibody.
Mavrilimumab (anti-CD116) (Ab170528) - SEC
The purity of Mavrilimumab (anti-CD116) (Ab170528) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IMGT/mAb-DB | 335 |
|---|---|
| Wikipedia | Mavrilimumab |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F0900982 | Certificate of Analysis | Sep 06, 2023 | Ab170528 |
| ZJ23F0900985 | Certificate of Analysis | Sep 06, 2023 | Ab170528 |
| 1. Nair JR, Edwards SW, Moots RJ. (2012) Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy.. Expert Opin Biol Ther, 12 (12): (1661-8). [PMID:23094973] [10.1021/op500134e] |
| 2. Burmester GR, McInnes IB, Kremer JM, Miranda P, Vencovský J, Godwood A, Albulescu M, Michaels MA, Guo X, Close D et al.. (2018) Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Monoclonal Antibody: Long-Term Safety and Efficacy in Patients With Rheumatoid Arthritis.. Arthritis Rheumatol, 70 (5): (679-689). [PMID:29361199] [10.1021/op500134e] |
| 3. Rappold, G G, Willson, T A TA, Henke, A A and Gough, N M NM.. (1992) Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region.. Genomics, [PMID:1358805] |
| 4. Crosier, K E KE, Wong, G G GG, Mathey-Prevot, B B, Nathan, D G DG and Sieff, C A CA.. (1991) A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain.. Proceedings of the National Academy of Sciences of the United States of America, (1): [PMID:1715577] |
| 5. Raines, M A MA and 5 more authors.. (1991) Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:1832774] |
| 6. Ashworth, A A and Kraft, A A.. (1990) Cloning of a potentially soluble receptor for human GM-CSF.. Nucleic acids research, (11): [PMID:2148207] |
| 7. Gearing, D P DP, King, J A JA, Gough, N M NM and Nicola, N A NA.. (1989) Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.. The EMBO journal, (1): [PMID:2555171] |
| 8. Hu, X X, Emanuel, P D PD and Zuckerman, K S KS.. (1994) Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor.. Biochimica et biophysica acta, (8): [PMID:8086503] |
| 9. Nakagawa, Y Y, Kosugi, H H, Miyajima, A A, Arai, K K and Yokota, T T.. (1994) Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily.. The Journal of biological chemistry, (8): [PMID:8144676] |
| 10. Ross, Mark T MT and 281 more authors.. (2005) The DNA sequence of the human X chromosome.. Nature, (17): [PMID:15772651] |
| 11. Xiao, Rong R and 5 more authors.. (2006) [Expression of soluble GM-CSF-Ralpha in patients with acute myeloid leukemia].. Zhongguo shi yan xue ye xue za zhi, [PMID:16638185] |
| 12. Chen, Jian J, Cárcamo, Juan M JM and Golde, David W DW.. (2006) The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling.. The Journal of biological chemistry, (4): [PMID:16760463] |
| 13. Wang, Ying Y and 8 more authors.. (2007) Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation.. Blood, (1): [PMID:17090651] |
| 14. Lencz, T T and 7 more authors.. (2007) Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia.. Molecular psychiatry, [PMID:17522711] |
| 15. Pelley, Jennifer L JL, Nicholls, Chris D CD, Beattie, Tara L TL and Brown, Christopher B CB.. (2007) Discovery and characterization of a novel splice variant of the GM-CSF receptor alpha subunit.. Experimental hematology, [PMID:17681666] |
| 16. Hansen, Guido G and 12 more authors.. (2008) The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.. Cell, (8): [PMID:18692472] |
| 17. Martinez-Moczygemba, Margarita M and 12 more authors.. (2008) Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1.. The Journal of experimental medicine, (24): [PMID:18955567] |
| 18. Suzuki, Takuji T and 14 more authors.. (2008) Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.. The Journal of experimental medicine, (24): [PMID:18955570] |
| 19. Han, Xuesheng X and Parker, Tory L TL.. (2017) Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts.. Pharmaceutical biology, [PMID:28407719] |
| 20. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352] |
