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SKU | Size | Availability | Price | Qty |
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M288108-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $147.90 | |
M288108-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $246.90 | |
M288108-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $474.90 | |
M288108-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $810.90 | |
M288108-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,385.90 |
Potent class I and IIb HDAC inhibitor
Specifications & Purity | ≥98%(HPLC) |
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Biochemical and Physiological Mechanisms | Potent class I and IIb HDAC inhibitor (IC50values are 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively). Suppresses proliferation and induces apoptosis of sarcoma cancer stem cells (CSCs) at concentrations >500 |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Product introduction: An inhibitor of class I and class IIb HDACs. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Histone deacetylase 8 inhibitor | INHIBITOR | ALA3192 | Histone deacetylase 8 | SINGLE PROTEIN | Homo sapiens | ||
Histone deacetylase 2 inhibitor | INHIBITOR | ALA1937 | Histone deacetylase 2 | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Histone deacetylase 2 inhibitor | INHIBITOR | ALA1937 | Histone deacetylase 2 | SINGLE PROTEIN | Homo sapiens | ||
Histone deacetylase 3 inhibitor | INHIBITOR | ALA1829 | Histone deacetylase 3 | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Histone deacetylase 3 inhibitor | INHIBITOR | ALA1829 | Histone deacetylase 3 | SINGLE PROTEIN | Homo sapiens | ||
Histone deacetylase 11 inhibitor | INHIBITOR | ALA3310 | Histone deacetylase 11 | SINGLE PROTEIN | Homo sapiens |
IUPAC Name | N-hydroxy-5-[[6-oxo-4-(4-phenylphenyl)-1H-pyrimidin-2-yl]sulfanyl]pentanamide |
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INCHI | InChI=1S/C21H21N3O3S/c25-19(24-27)8-4-5-13-28-21-22-18(14-20(26)23-21)17-11-9-16(10-12-17)15-6-2-1-3-7-15/h1-3,6-7,9-12,14,27H,4-5,8,13H2,(H,24,25)(H,22,23,26) |
InChi Key | AOFVDNFTELWRHV-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC(=O)NC(=N3)SCCCCC(=O)NO |
Isomeric SMILES | C1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC(=O)NC(=N3)SCCCCC(=O)NO |
PubChem CID | 136173089 |
Molecular Weight | 395.47 |
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Solubility | Solvent:DMSO, Max Conc. mg/mL: 39.55, Max Conc. mM: 100 |
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