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MC180295 - 99%, high purity , CAS No.2237942-08-2
CDK9 Selective Inhibitors
Basic Description Synonyms MC180295 | 2237942-08-2 | CHEMBL4764481 | (4-amino-2-{[(1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone | [4-amino-2-[[(1S,2S,4R)-2-bicyclo[2.2.1]heptanyl]amino]-1,3-thiazol-5-yl]-(2-nitrophenyl)methanone | DTXSID001115307 | EX-A3 Specifications & Purity ≥99% Biochemical and Physiological Mechanisms MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Information
MC180295 ((rel)-MC180295) is a novel potent and selectiveCDK9inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs.
Targets
CDK9-Cyclin T1 (Cell-free assay); CDK4-Cyclin D (Cell-free assay); CDK1-Cyclin B (Cell-free assay); CDK5-P35 (Cell-free assay); CDK5-P25 (Cell-free assay) 31874,5 nM; 112 nM; 138 nM; 159 nM; 186 nM
In vitro
MC180295 has broad anti-cancer activity in vitro.
In vivo
MC180295 shows promising anti-tumoral and immunosensitization activity.
Cell Research(from reference)
Cell lines：Normal lung fibroblast (IMR90) and cancer cell lines (HCT116, KG-1, HL-60, SW48, MCF7, DU145 and LnCaP)
Concentrations：0.1 μM
Incubation Time：4 days
Associated Targets(Human) Names and Identifiers IUPAC Name [4-amino-2-[[(1S,2S,4R)-2-bicyclo[2.2.1]heptanyl]amino]-1,3-thiazol-5-yl]-(2-nitrophenyl)methanone INCHI InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8-9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9-,10+,12+/m1/s1 InChi Key JRNXAQINDCOHGS-SCVCMEIPSA-N Canonical SMILES C1CC2CC1CC2NC3=NC(=C(S3)C(=O)C4=CC=CC=C4[N+](=O)[O-])N Isomeric SMILES C1C[C@H]2C[C@@H]1C[C@@H]2NC3=NC(=C(S3)C(=O)C4=CC=CC=C4[N+](=O)[O-])N PubChem CID 137333456 Molecular Weight 358.41
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 72 mg/mL (200.88 mM); Ethanol: 72 mg/mL (200.88 mM); Water: Insoluble;
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