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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M414276-2mg | 2mg | In stock | $39.90 | |
M414276-5mg | 5mg | In stock | $49.90 | |
M414276-10mg | 10mg | In stock | $84.90 | |
M414276-50mg | 50mg | In stock | $326.90 | |
M414276-100mg | 100mg | In stock | $555.90 |
NLRP3 Inhibitors
Synonyms | 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide | CRID3 | CP-456,773 | 6RS86E2BWQ |
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Specifications & Purity | Moligand™, ≥97% |
Biochemical and Physiological Mechanisms | MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of NLRP3 |
Product Description | Information MCC950 MCC950 is a potent and selective inhibitor of NLRP3 with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. Targets NLRP3 (BMDM-based assay); NLRP3 (HMDM-based assay) 7.5 nM; 8.1 nM In vitro MCC950 is a potent, selective, small molecule inhibitor of NLRP3. MCC950 blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. MCC950 is active in ex vivo samples from individuals with Muckle-Wells syndrome. MCC950 reduces Interleukin-1p (IL-1β) production in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS. Cell Research(from reference) Cell lines:BMDM, HMDM, PBMC, HEK293T cells Concentrations:0.001 μM–10 μM, 5 nM–1000 nM Incubation Time:30 min, 45 min |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488196420 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488196420 |
IUPAC Name | 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea |
INCHI | InChI=1S/C20H24N2O5S/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23) |
InChi Key | HUUSXLKCTQDPGL-UHFFFAOYSA-N |
Canonical SMILES | CC(C)(C1=COC(=C1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4)O |
Isomeric SMILES | CC(C)(C1=COC(=C1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4)O |
PubChem CID | 9910393 |
Molecular Weight | 404.48 |
PubChem CID | 9910393 |
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CAS Registry No. | 210826-40-7 |
ChEMBL Ligand | CHEMBL3183703 |
RCSB PDB Ligand | 8GI, 8GI |
PubChem SID | 488196420 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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E2416333 | Certificate of Analysis | Apr 28, 2024 | M414276 |
E2416334 | Certificate of Analysis | Apr 28, 2024 | M414276 |
E2416335 | Certificate of Analysis | Apr 28, 2024 | M414276 |
E2416336 | Certificate of Analysis | Apr 28, 2024 | M414276 |
I2410220 | Certificate of Analysis | Apr 28, 2024 | M414276 |
D2422048 | Certificate of Analysis | Apr 26, 2023 | M414276 |
E23301359 | Certificate of Analysis | Apr 26, 2023 | M414276 |
E23301362 | Certificate of Analysis | Apr 26, 2023 | M414276 |
E23301375 | Certificate of Analysis | Apr 26, 2023 | M414276 |
E23301376 | Certificate of Analysis | Apr 26, 2023 | M414276 |
E23301379 | Certificate of Analysis | Apr 26, 2023 | M414276 |
E23301380 | Certificate of Analysis | Apr 26, 2023 | M414276 |
E23301381 | Certificate of Analysis | Apr 26, 2023 | M414276 |
E23301384 | Certificate of Analysis | Apr 26, 2023 | M414276 |
E23301387 | Certificate of Analysis | Apr 26, 2023 | M414276 |
E23301401 | Certificate of Analysis | Apr 26, 2023 | M414276 |
Solubility | Solubility (25°C) In vitro DMSO: 81 mg/mL (200.25 mM); Ethanol: 3 mg/mL (7.41 mM); Water: Insoluble; |
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Starting at $241.90
Starting at $58.90
1. De-Wen Bi, Ying-Xin Zhao, Xiong Qiu, Xue-Cong Zhang, Ya-Ling Zhou, Muhammad Aurang Zeb, Wen-Hui Pang, Rui Li, Meng-Ru Wang, Bin Cheng, Jing-Jing Zhang, Xing-Jie Zhang, Xiao-Li Li, Rui-Han Zhang, Wei-Lie Xiao. (2022) Callicarpanes A–L, Twelve New Clerodane Diterpenoids with NLRP3 Inflammasome Inhibitory Activity from Callicarpa integerrima. CHEMISTRY & BIODIVERSITY, 20 (1): (e202200985). [PMID:36433761] [10.1002/cbdv.202200985] |
1. Tate MD, Ong JDH, Dowling JK, McAuley JL, Robertson AB, Latz E, Drummond GR, Cooper MA, Hertzog PJ, Mansell A. (2016) Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition.. Sci Rep, 6 (13): (27912). [PMID:27283237] [10.1021/op500134e] |
2. Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A et al.. (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.. Nat Med, 21 (3): (248-55). [PMID:25686105] [10.1021/op500134e] |
3. Coates BM, Staricha KL, Ravindran N, Koch CM, Cheng Y, Davis JM, Shumaker DK, Ridge KM. (2017) Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection.. Front Immunol, 8 (13): (782). [PMID:28740490] [10.1021/op500134e] |
4. Hettwer J, Hinterdobler J, Miritsch B, Deutsch MA, Li X, Mauersberger C, Moggio A, Braster Q, Gram H, Robertson AAB et al.. (2021) Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis.. Cardiovasc Res, 71 (13): (1755-70). [PMID:34718444] [10.1093/cvr/cvab337] |
5. Ni B, Pei W, Qu Y, Zhang R, Chu X, Wang Y, Huang X, You H. (2021) MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.. Oxid Med Cell Longev, 2021 (13): (4139048). [PMID:34777685] [10.1021/op500134e] |
6. Kennedy CR, Goya Grocin A, Kovačič T, Singh R, Ward JA, Shenoy AR, Tate EW. (2021) A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target.. ACS Chem Biol, 16 (6): (982-990). [PMID:34003636] [10.1021/op500134e] |
7. Corcoran SE, Halai R, Cooper MA. (2021) Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950.. Pharmacol Rev, 73 (3): (968-1000). [PMID:34117094] [10.1021/op500134e] |
8. Zeng W, Wu D, Sun Y, Suo Y, Yu Q, Zeng M, Gao Q, Yu B, Jiang X, Wang Y. (2021) The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages.. Sci Rep, 11 (1): (19305). [PMID:34588488] [10.1021/op500134e] |
9. Wang S, Yuan YH, Chen NH, Wang HB. (2019) The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease.. Int Immunopharmacol, 67 (13): (458-464). [PMID:30594776] [10.1021/op500134e] |
10. Coll RC, Hill JR, Day CJ, Zamoshnikova A, Boucher D, Massey NL, Chitty JL, Fraser JA, Jennings MP, Robertson AAB et al.. (2019) MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.. Nat Chem Biol, 15 (6): (556-559). [PMID:31086327] [10.1021/op500134e] |
11. Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D et al.. (2019) NLRP3 inflammasome activation drives tau pathology.. Nature, 575 (7784): (669-673). [PMID:31748742] [10.1021/op500134e] |
12. Dekker C, Mattes H, Wright M, Boettcher A, Hinniger A, Hughes N, Kapps-Fouthier S, Eder J, Erbel P, Stiefl N et al.. (2021) Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.. J Mol Biol, 433 (24): (167309). [PMID:34687713] [10.1021/op500134e] |
13. Wang Z, Zhang S, Xiao Y, Zhang W, Wu S, Qin T, Yue Y, Qian W, Li L. (2020) NLRP3 Inflammasome and Inflammatory Diseases.. Oxid Med Cell Longev, 2020 (13): (4063562). [PMID:32148650] [10.1021/op500134e] |
14. Fenini G, Contassot E, French LE. (2017) Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases.. Front Pharmacol, 8 (13): (278). [PMID:28588486] [10.1021/op500134e] |
15. De-Wen Bi, Ying-Xin Zhao, Xiong Qiu, Xue-Cong Zhang, Ya-Ling Zhou, Muhammad Aurang Zeb, Wen-Hui Pang, Rui Li, Meng-Ru Wang, Bin Cheng, Jing-Jing Zhang, Xing-Jie Zhang, Xiao-Li Li, Rui-Han Zhang, Wei-Lie Xiao. (2022) Callicarpanes A–L, Twelve New Clerodane Diterpenoids with NLRP3 Inflammasome Inhibitory Activity from Callicarpa integerrima. CHEMISTRY & BIODIVERSITY, 20 (1): (e202200985). [PMID:36433761] [10.1002/cbdv.202200985] |