Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M288419-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $29.90 | |
M288419-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $48.90 | |
M288419-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $98.90 | |
M288419-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $157.90 | |
M288419-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $246.90 |
Selective M1muscarinic agonist
Synonyms | McN-A-343 | A 343 | MCN-343 | MS-24679 | McN-A 343 | SR-01000075310 | C 7041 | 2-Butyn-1-aminium, 4-((((3-chlorophenyl)amino)carbonyl)oxy)-N,N,N-trimethyl-, chloride | CW55R761RE | MLS000859939 | (4-Hydroxy-2-butynyl)-1-trimethylammonium-m-chlorocarbanila |
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Specifications & Purity | Moligand™, ≥99%(HPLC) |
Biochemical and Physiological Mechanisms | Selective muscarinic M1receptor agonist. Selectivity for M1over other muscarinic receptor types appears to arise from a high efficacy at M1receptors. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of M 1 receptor;Agonist of M 2 receptor;Agonist of M 3 receptor;Agonist of M 4 receptor;Agonist of M 5 receptor |
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IUPAC Name | 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium;chloride |
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INCHI | InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H |
InChi Key | CXFZFEJJLNLOTA-UHFFFAOYSA-N |
Canonical SMILES | C[N+](C)(C)CC#CCOC(=O)NC1=CC(=CC=C1)Cl.[Cl-] |
Isomeric SMILES | C[N+](C)(C)CC#CCOC(=O)NC1=CC(=CC=C1)Cl.[Cl-] |
PubChem CID | 5926 |
Molecular Weight | 317.21 |
PubChem CID | 5926 |
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ChEMBL Ligand | CHEMBL74300 |
BindingDB Ligand | 50006584 |
CAS Registry No. | 55-45-8 |
GPCRdb Ligand | McN-A-343 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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C2329297 | Certificate of Analysis | Jan 06, 2023 | M288419 |
C2329368 | Certificate of Analysis | Jan 06, 2023 | M288419 |
C2329369 | Certificate of Analysis | Jan 06, 2023 | M288419 |
C2329399 | Certificate of Analysis | Jan 06, 2023 | M288419 |
C2329400 | Certificate of Analysis | Jan 06, 2023 | M288419 |
Solubility | Solvent:water, Max Conc. mg/mL: 31.72, Max Conc. mM: 100 |
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1. Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP et al.. (2014) International union of basic and clinical pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.. Pharmacol Rev, 66 (4): (918-47). [PMID:25026896] [10.1021/op500134e] |