MDBN - 10mM in DMSO, high purity , CAS No.1485-00-3

Item Number

M421742

• Synonyms: 3,4-Methylenedioxy-beta-nitrostyrene | 1485-00-3 | MNS | Syk Inhibitor III | NSC 10120 | 22568-48-5 | NSC 105303 | NSC 170724 | (E)-5-(2-nitrovinyl)benzo[d][1,3]dioxole | 1,3-Benzodioxole, 5-(2-nitroethenyl)- | 1,3-Benzodioxole, 5-nitrovinyl- | CHEMBL596380 | 3,4-Methylenedioxyb
• Specifications & Purity: Moligand™, 10mM in DMSO
• Biochemical and Physiological Mechanisms: Potent, irreversible p97 inhibitor. Also inhibits Tyrosine kinase. Inhibits growth and induces apoptosis in tumor cells.Cell permeable: yes Primary Target Syk Target IC50: 2.5 µM against Syk kinase activity Product does not compete with ATP. Reversible: n
• Storage Temp: Protected from light,Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

product description：

A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).

Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic ac