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MDR-652 - 97%, high purity , CAS No.1933528-96-1

≥97%

CAS#: 1933528-96-1
Formula: C₂₂H₂₃ClFN₃O₂S
Molecular Weight: 447.95
PubChem CID: 121364823

Item Number

M412573

Grouped product items
SKU	Size	Availability	Price
M412573-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$63.90
M412573-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$154.90
M412573-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$234.90
M412573-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$423.90
M412573-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$639.90
M412573-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$910.90

TRP Channel Agonists

Basic Description

Synonyms	N-[[4-(3-chlorophenyl)-2-(1,1-dimethylethyl)-5-thiazolyl]methyl]-N'-[3-fluoro-4-(hydroxymethyl)phenyl]-urea
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information MDR-652 MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity. Targets hTRPV1 (Cell-free assay); rTRPV1 (Cell-free assay) 11.4 nM(Ki); 23.8 nM(Ki)

Associated Targets(Human)

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 (2 Activities)

Discover Target: TRPV1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV1 Tclin Vanilloid receptor (8273 Activities)

Discover Target: TRPV1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (542 Activities)

Discover Target: TRPV3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)

Discover Target: Trpa1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpm8 Transient receptor potential cation channel subfamily M member 8 (889 Activities)

Discover Target: Trpm8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-[[2-tert-butyl-4-(3-chlorophenyl)-1,3-thiazol-5-yl]methyl]-3-[3-fluoro-4-(hydroxymethyl)phenyl]urea
INCHI	InChI=1S/C22H23ClFN3O2S/c1-22(2,3)20-27-19(13-5-4-6-15(23)9-13)18(30-20)11-25-21(29)26-16-8-7-14(12-28)17(24)10-16/h4-10,28H,11-12H2,1-3H3,(H2,25,26,29)
InChi Key	HKMPJRGWSUCANB-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=NC(=C(S1)CNC(=O)NC2=CC(=C(C=C2)CO)F)C3=CC(=CC=C3)Cl
Isomeric SMILES	CC(C)(C)C1=NC(=C(S1)CNC(=O)NC2=CC(=C(C=C2)CO)F)C3=CC(=CC=C3)Cl
PubChem CID	121364823
Molecular Weight	447.95

Certificates

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12 results found

Lot Number	Certificate Type	Date	Item
A2422056	Certificate of Analysis	Dec 21, 2023	M412573
A2422057	Certificate of Analysis	Dec 21, 2023	M412573
A2422058	Certificate of Analysis	Dec 21, 2023	M412573
A2422059	Certificate of Analysis	Dec 21, 2023	M412573
A2422060	Certificate of Analysis	Dec 21, 2023	M412573
A2422061	Certificate of Analysis	Dec 21, 2023	M412573
A2422062	Certificate of Analysis	Dec 21, 2023	M412573
A2422063	Certificate of Analysis	Dec 21, 2023	M412573
A2422064	Certificate of Analysis	Dec 21, 2023	M412573
A2422066	Certificate of Analysis	Dec 21, 2023	M412573
A2422067	Certificate of Analysis	Dec 21, 2023	M412573
A2422069	Certificate of Analysis	Dec 21, 2023	M412573

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