Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M111946-250mg | 250mg | In stock | $9.90 | |
M111946-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $38.90 | |
M111946-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $71.90 |
Benzimidazole antihelmintic. Tubulin-disrupting drug.
Synonyms | 81G6I5V05I | Mebendazol | NCGC00016806-01 | Verpanyl | Equivurm Plus | HSDB 3232 | MEBENDAZOLE [USP-RS] | methyl N-(6-benzoyl-1H-benzimidazol-2-yl)carbamate | MEBENDAZOLE [USP IMPURITY] | NSC 184849 | Ovitelmin | Spectrum2_001401 | Mebendazol [INN-Spanish |
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Specifications & Purity | analytical standard |
Biochemical and Physiological Mechanisms | Benzimidazole antihelmintic. Tubulin-disrupting drug. Antitumour activity in vitro and in vivo . Inhibits growth and induces apoptosis. |
Shipped In | Normal |
Grade | analytical standard |
Action Type | INHIBITOR |
Mechanism of action | Tubulin inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 2.8 |
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IUPAC Name | methyl N-(6-benzoyl-1H-benzimidazol-2-yl)carbamate |
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INCHI | InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21) |
InChi Key | OPXLLQIJSORQAM-UHFFFAOYSA-N |
Canonical SMILES | COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3 |
Isomeric SMILES | COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3 |
RTECS | EY8600000 |
PubChem CID | 4030 |
Molecular Weight | 295.29 |
Reaxy-Rn | 759809 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
C2113098 | Certificate of Analysis | Dec 13, 2022 | M111946 |
C2113099 | Certificate of Analysis | Dec 13, 2022 | M111946 |
C2113100 | Certificate of Analysis | Dec 13, 2022 | M111946 |
G2322671 | Certificate of Analysis | Nov 23, 2022 | M111946 |
G2322679 | Certificate of Analysis | Nov 23, 2022 | M111946 |
G2322683 | Certificate of Analysis | Nov 23, 2022 | M111946 |
Melt Point(°C) | 288.5°C |
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RTECS | EY8600000 |
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Reaxy-Rn | 759809 |
1. Wang Zile, Zhang Liang, Yang YanHong, Zhang Huixia, Zhang Weichunbai, Zheng Pimiao, Jiang Haiyang. (2022) Rational hapten design and establishment of broad-spectrum indirect competitive enzyme-linked immunosorbent assay for benzimidazoles monitoring in milk. Food Quality and Safety, 7 [PMID:] |
2. Yuanjin Zhang, Jing Gao, Yuan Xu, Jie Liu, Shengbo Huang, Guihong Li, Bingyi Yao, Zhenliang Sun, Xin Wang. (2022) Investigation of cytochrome P450 inhibitory properties of deoxyshikonin, a bioactive compound from Lithospermum erythrorhizon Sieb. et Zucc. PHYTOTHERAPY RESEARCH, [PMID:36317387] |
3. Wang Xu, Fa Jingjing, Zhang Yuanjin, Huang Shengbo, Liu Jie, Gao Junqing, Xing Lina, Liu Zongjun, Wang Xin. (2022) Evaluation of Herb–Drug Interaction Between Danshen and Rivaroxaban in Rat and Human Liver Microsomes. Frontiers in Pharmacology, 13 [PMID:35928264] |
4. Jie Liu, Yi Cheng, Yuanjin Zhang, Shengbo Huang, Zongjun Liu, Xin Wang. (2021) Lactobacillus rhamnosus induces CYP3A and changes the pharmacokinetics of verapamil in rats. TOXICOLOGY LETTERS, 352 (46). [PMID:34600097] |
5. Qing Hu, Han Lin, Yanfang Wang, Xiaoqin Wang, Jiayi Yao, Xiaoling Fu, Xiangbin Yu. (2021) Design, optimization and evaluation of a microemulsion-based hydrogel with high malleability for enhanced transdermal delivery of levamisole. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 605 (120829). [PMID:34174358] |
6. Han Luo, Yuan Xu, Dongyi Sun, Yi Cheng, Zhenliang Sun, Jing Gao, Yuanjin Zhang, Xin Wang. (2020) Assessment of the inhibition risk of paris saponins, bioactive compounds from Paris polyphylla, on CYP and UGT enzymes via cocktail inhibition assays. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 113 (104637). [PMID:32145316] |
1. Wang Zile, Zhang Liang, Yang YanHong, Zhang Huixia, Zhang Weichunbai, Zheng Pimiao, Jiang Haiyang. (2022) Rational hapten design and establishment of broad-spectrum indirect competitive enzyme-linked immunosorbent assay for benzimidazoles monitoring in milk. Food Quality and Safety, 7 [PMID:] |
2. Yuanjin Zhang, Jing Gao, Yuan Xu, Jie Liu, Shengbo Huang, Guihong Li, Bingyi Yao, Zhenliang Sun, Xin Wang. (2022) Investigation of cytochrome P450 inhibitory properties of deoxyshikonin, a bioactive compound from Lithospermum erythrorhizon Sieb. et Zucc. PHYTOTHERAPY RESEARCH, [PMID:36317387] |
3. Wang Xu, Fa Jingjing, Zhang Yuanjin, Huang Shengbo, Liu Jie, Gao Junqing, Xing Lina, Liu Zongjun, Wang Xin. (2022) Evaluation of Herb–Drug Interaction Between Danshen and Rivaroxaban in Rat and Human Liver Microsomes. Frontiers in Pharmacology, 13 [PMID:35928264] |
4. Jie Liu, Yi Cheng, Yuanjin Zhang, Shengbo Huang, Zongjun Liu, Xin Wang. (2021) Lactobacillus rhamnosus induces CYP3A and changes the pharmacokinetics of verapamil in rats. TOXICOLOGY LETTERS, 352 (46). [PMID:34600097] |
5. Qing Hu, Han Lin, Yanfang Wang, Xiaoqin Wang, Jiayi Yao, Xiaoling Fu, Xiangbin Yu. (2021) Design, optimization and evaluation of a microemulsion-based hydrogel with high malleability for enhanced transdermal delivery of levamisole. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 605 (120829). [PMID:34174358] |
6. Han Luo, Yuan Xu, Dongyi Sun, Yi Cheng, Zhenliang Sun, Jing Gao, Yuanjin Zhang, Xin Wang. (2020) Assessment of the inhibition risk of paris saponins, bioactive compounds from Paris polyphylla, on CYP and UGT enzymes via cocktail inhibition assays. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 113 (104637). [PMID:32145316] |