Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M129409-1g | 1g | In stock | $95.90 | |
M129409-5g | 5g | In stock | $361.90 | |
M129409-25g | 25g | In stock | $1,624.90 | |
M129409-100g | 100g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $5,848.90 |
Angiostatic steroid. Potent progesterone receptor agonist
Synonyms | Clinovir | DP150 | Medroxyprogesterone acetate (Standard) | Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6alpha)- | Depocon | Veramix | Depo-subq provera | MAP | Veraplex | 6-alpha-Methyl-17-alpha-acetoxyprogesterone | 6alpha-Methyl-17alpha-acetoxyp |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Medroxyprogesterone 17-Acetate is an angiostatic steroid, found to inhibit tumor growth, collagenolysis, vascularization, and plasmin generation. It is a synthetic variant of progesterone, and a potent progesterone receptor (PR) agonist.Angiostatic steroi |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | AGONIST |
Mechanism of action | Progesterone receptor agonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist. |
ALogP | 4.1 |
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IUPAC Name | [(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate |
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INCHI | InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1 |
InChi Key | PSGAAPLEWMOORI-PEINSRQWSA-N |
Canonical SMILES | CC1CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C |
Isomeric SMILES | C[C@H]1C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C |
WGK Germany | 3 |
RTECS | TU5010000 |
PubChem CID | 6279 |
Molecular Weight | 386.52 |
Beilstein | 2066112 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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C1810016 | Certificate of Analysis | Aug 07, 2023 | M129409 |
L2307161 | Certificate of Analysis | Aug 07, 2023 | M129409 |
C1810015 | Certificate of Analysis | Aug 07, 2023 | M129409 |
D2303676 | Certificate of Analysis | Apr 12, 2023 | M129409 |
L2201328 | Certificate of Analysis | Dec 06, 2022 | M129409 |
Solubility | Soluble in DMF, ethanol (12 mg/ml at 25 °C), methanol (sparingly), DMSO (12 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C). |
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Melt Point(°C) | 206-207°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H360:May damage fertility or the unborn child H362:May cause harm to breast-fed children |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. |
WGK Germany | 3 |
RTECS | TU5010000 |
1. Zu Qiang Jiang, Lei Zhang, Cui Juan Lan, Jian Ping Wang. (2023) Development of a Progesterone-Receptor-Based Pseudo-immunoassay for Multi-detection of Progestins in Milk and Studying Its Recognition Mechanism. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:37938156] |
2. Yan Su, Gelin Liu, Haozhe Hou, Yaojia Peng, Jianping Wang. (2023) Development of a Magnetic Molecularly Imprinted Microsphere-Based Signal Amplified Semi-Homogeneous Method for Multidetection of Five Progestins in Milk. Foods, 12 (15): (2818). [PMID:37569089] |
3. Zhefei Hu, Yanhao Jiang, Panpan Cao, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Performance evaluation of 2-undecylimidazole/propyl methacrylate bifunctional silica gel for mixed-mode reversed-phase/anion-exchange chromatography. MICROCHEMICAL JOURNAL, 191 (108768). [PMID:] |
4. Liling Wang, Huan Wang, Jing Luo, Ting Xie, Gil Mor, Aihua Liao. (2022) Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss. Theranostics, 12 (17): ( 7216–7236). [PMID:36438479] |
1. Zu Qiang Jiang, Lei Zhang, Cui Juan Lan, Jian Ping Wang. (2023) Development of a Progesterone-Receptor-Based Pseudo-immunoassay for Multi-detection of Progestins in Milk and Studying Its Recognition Mechanism. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:37938156] |
2. Yan Su, Gelin Liu, Haozhe Hou, Yaojia Peng, Jianping Wang. (2023) Development of a Magnetic Molecularly Imprinted Microsphere-Based Signal Amplified Semi-Homogeneous Method for Multidetection of Five Progestins in Milk. Foods, 12 (15): (2818). [PMID:37569089] |
3. Zhefei Hu, Yanhao Jiang, Panpan Cao, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Performance evaluation of 2-undecylimidazole/propyl methacrylate bifunctional silica gel for mixed-mode reversed-phase/anion-exchange chromatography. MICROCHEMICAL JOURNAL, 191 (108768). [PMID:] |
4. Liling Wang, Huan Wang, Jing Luo, Ting Xie, Gil Mor, Aihua Liao. (2022) Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss. Theranostics, 12 (17): ( 7216–7236). [PMID:36438479] |