Melatonin - 98%, high purity , CAS No.73-31-4, Antagonist of 5-HT 2B receptor;Agonist of MT 1 receptor;Agonist of MT 2 receptor

24 Citations
Item Number
M118674
Grouped product items
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M118674-5g
5g
In stock
$9.90
M118674-25g
25g
In stock
$24.90
M118674-100g
100g
In stock
$79.90
M118674-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$260.90

Endogenous hormone; agonist at MT 1 and MT 2 receptors

Basic Description

Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsHormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death o
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST, ANTAGONIST
Mechanism of actionAntagonist of 5-HT 2B receptor;Agonist of MT 1 receptor;Agonist of MT 2 receptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Melatonin (N-acetyl-5-methoxytryptamine) is synthesized from an essential amino acid tryptophan. It is a pineal gland neurohormone. Direct, non-receptor-mediated free radical scavenging activity induced by melatonin, makes it unique from other classic hormones. Melatonin is expressed in variety of organisms such as bacteria, algae, fungi, plants, insects, and vertebrates including humans.

Product Properties

ALogP0.8

Associated Targets(Human)

HRH3 Tclin Histamine H3 receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HTR2B Tclin 5-hydroxytryptamine receptor 2B (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NQO2 Tchem Ribosyldihydronicotinamide dehydrogenase [quinone] (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MTNR1A Tclin Melatonin receptor type 1A (81 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MTNR1B Tclin Melatonin receptor type 1B (71 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP19A1 Tclin Cytochrome P450 19A1 (6099 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Melatonin receptor 1B (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aplnr Apelin receptor (201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Melatonin receptor 1C (17 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Faah Anandamide amidohydrolase (3907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Xenopus laevis (337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-12 (7051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C6 (2371 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-22 (3261 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Melanophore (216 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
clpP ATP-dependent Clp protease proteolytic subunit (245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cacna1c Voltage-gated L-type calcium channel (1164 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glra2 Glycine receptor (1745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488179568
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179568
IUPAC Name N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
INCHI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
InChi Key DRLFMBDRBRZALE-UHFFFAOYSA-N
Canonical SMILES CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
Isomeric SMILES CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
RTECS AC5955000
Alternate CAS 73-31-4,8041-44-9
PubChem CID 896
NSC Number 56423
MeSH Entry Terms Melatonin
Molecular Weight 232.28
Beilstein 205542
Reaxy-Rn 205542

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

23 results found

Lot NumberCertificate TypeDateItem
G2429396Certificate of AnalysisJul 12, 2024 M118674
G2429395Certificate of AnalysisJul 12, 2024 M118674
G2429397Certificate of AnalysisJul 12, 2024 M118674
E2406133Certificate of AnalysisApr 20, 2024 M118674
E2406112Certificate of AnalysisApr 20, 2024 M118674
E2406102Certificate of AnalysisApr 20, 2024 M118674
E2406101Certificate of AnalysisApr 20, 2024 M118674
D2407404Certificate of AnalysisMar 12, 2024 M118674
K2317200Certificate of AnalysisNov 03, 2023 M118674
K2317116Certificate of AnalysisNov 03, 2023 M118674
K2317119Certificate of AnalysisNov 03, 2023 M118674
K2317122Certificate of AnalysisNov 03, 2023 M118674
C2324918Certificate of AnalysisMar 09, 2023 M118674
C23241209Certificate of AnalysisMar 09, 2023 M118674
C23241138Certificate of AnalysisMar 09, 2023 M118674
C23241134Certificate of AnalysisMar 09, 2023 M118674
C23241132Certificate of AnalysisMar 09, 2023 M118674
E2013132Certificate of AnalysisFeb 13, 2023 M118674
C2208286Certificate of AnalysisDec 29, 2021 M118674
C2208304Certificate of AnalysisDec 29, 2021 M118674
C2208303Certificate of AnalysisDec 29, 2021 M118674
C2208289Certificate of AnalysisDec 29, 2021 M118674
C2208287Certificate of AnalysisDec 29, 2021 M118674

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Chemical and Physical Properties

SolubilitySoluble in ethanol to at least 50mg/ml
Sensitivitylight sensitive;air sensitive
Melt Point(°C)118°C

Safety and Hazards(GHS)

RTECS AC5955000
Reaxy-Rn 205542
Merck Index 5816

Related Documents

Citations of This Product

1. Shanshan Tang, Miao Liu, Wei Wang, Axin Liang, Fulai Zhang, Aiqin Luo.  (2023)  An amorphous zinc/copper double transition metal hydroxides for electrochemical simultaneous detection of dopamine, serotonin, and melatonin.  NEW JOURNAL OF CHEMISTRY,  47  (35): (16337-16344).  [PMID:]
2. Pan Hu, Xin Yan, Yijia Zeng, Zherui Jiang, Juan Liu, Wu-wen Feng.  (2023)  An UPLC-MS/MS method for targeted analysis of microbial and host tryptophan metabolism after administration of polysaccharides from Atractylodes macrocephala Koidz. in ulcerative colitis mice.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  235  (115585).  [PMID:37523866]
3. Ruiqing Bi, Renjian Li, Zhenyi Xu, Huanyu Cai, Juan Zhao, Yaru Zhou, Bangting Wu, Peng Sun, Wei Yang, Lu Zheng, Xiao-Lin Chen, Chao-Xi Luo, Huailong Teng, Qiang Li, Guotian Li.  (2023)  Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control.  JOURNAL OF PINEAL RESEARCH,  75  (2): (e12896).  [PMID:37458404]
4. Mingying Wang, Jin Xu, Zhaoyang Ding, Jing Xie.  (2023)  Prolong the postharvest shelf life of spinach through the antioxidative ability of melatonin.  Food Chemistry-X,  19  (100769).  [PMID:37780277]
5. Xiaofei Ren, Kui Xu, Jianming Xu, Qiao Mei.  (2023)  Melatonin attenuates monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats via activation of Sirtuin-3.  JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,    (e23422).  [PMID:37350538]
6. Lu Lu, Jingming Ren, Tong Yuan, Xinran Lu, Yinping Dong, Wenxuan Li, Xinyue Wang, Qidong Huo, Junling Zhang, Deguan Li, Saijun Fan.  (2023)  High-fat diet alters the radiation tolerance of female mice and the modulatory effect of melatonin.  Food & Function,      [PMID:37401725]
7. Tang Shanshan, Liang Axin, Liu Miao, Wang Wei, Zhang Fulai, Luo Aiqin.  (2023)  A glassy carbon electrode modified with a composite consisting of electrodeposited chitosan and carboxylated multi-walled carbon nanotubes for simultaneous voltammetric determination of dopamine, serotonin and melatonin.  Carbon Letters,  33  (7): (2129-2139).  [PMID:]
8. Qixing Nie, Yonggan Sun, Mingzhi Li, Sheng Zuo, Chunhua Chen, Qiongni Lin, Shaoping Nie.  (2023)  Targeted modification of gut microbiota and related metabolites via dietary fiber.  CARBOHYDRATE POLYMERS,  316  (120986).  [PMID:37321707]
9. Qi Lou, Lu Pan, Shengjin Xiang, Yueting Li, Jiahui Jin, Jingyang Tan, Baoshan Huang, Kaihui Nan, Sen Lin.  (2023)  Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease.  International Journal of Nanomedicine,      [PMID:37192892]
10. Tingyan Liu, Caiyan Zhang, Jiayun Ying, Yaodong Wang, Gangfeng Yan, Yufeng Zhou, Guoping Lu.  (2023)  Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis.  Frontiers in Immunology,  14  (1134556).  [PMID:37205094]
11. Zhuoshi Lian, Ying Xu, Chan Wang, Ye Chen, Li Yuan, Zhongyu Liu, Yarui Liu, Peishi He, Zheng Cai, Jie Zhao.  (2023)  Gut microbiota-derived melatonin from Puerariae Lobatae Radix-resistant starch supplementation attenuates ischemic stroke injury via a positive microbial co-occurrence pattern.  PHARMACOLOGICAL RESEARCH,  190  (106714).  [PMID:36863429]
12. Qiuyang Huang, Xiaoling Zang, Zhiwei Zhang, Hang Yu, Baoyan Ding, Zhuangzhuang Li, Simin Cheng, Xin Zhang, Mustafa R.K. Ali, Xue Qiu, Zhihua Lv.  (2023)  Study on endogenous inhibitors against PD-L1: cAMP as a potential candidate.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  230  (123266).  [PMID:36646351]
13. Xin Huang, Rui Wang, Yikai Wang, Changbao Chen, Shuying Liu.  (2023)  Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging.  JOURNAL OF ETHNOPHARMACOLOGY,  303  (116006).  [PMID:36516905]
14. Renjian Li, Ruiqing Bi, Huanyu Cai, Juan Zhao, Peng Sun, Weilong Xu, Yaru Zhou, Wei Yang, Lu Zheng, Xiao-Lin Chen, Guanghui Wang, Dongli Wang, Junfeng Liu, Huailong Teng, Guotian Li.  (2022)  Melatonin functions as a broad-spectrum antifungal by targeting a conserved pathogen protein kinase.  JOURNAL OF PINEAL RESEARCH,  74  (1): (e12839).  [PMID:36314656]
15. Wang Hongbo, Li Jing, Jin Jianbo, Hu Jingbo, Yang Chunlin.  (2022)  Enhanced efficiency of melatonin by stepwise-targeting strategy for acute lung injury.  Frontiers in Bioengineering and Biotechnology,  10    [PMID:36159679]
16. Giridhar Babu Anam, Dinneswara Reddy Guda, Young-Ho Ahn.  (2022)  Impact of melatonin on the hydrogen peroxide treatment efficacy in Microcystis aeruginosa: Cell growth, oxidative stress response, and gene transcription.  CHEMOSPHERE,  307  (136036).  [PMID:36007744]
17. Chen Dongmei, Lan Guihua, Li Ruomeng, Mei Yingxue, Shui Xindong, Gu Xi, Wang Long, Zhang Tao, Gan Chen-Ling, Xia Yongfang, Hu Li, Tian Yuan, Zhang Mi, Lee Tae Ho.  (2022)  Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease.  Translational Neurodegeneration,  11  (1): (1-19).  [PMID:35527277]
18. Hongbin Chen, Hetong Lin, Xuanjing Jiang, Mengshi Lin, Zhongqi Fan.  (2022)  Amelioration of chilling injury and enhancement of quality maintenance in cold-stored guava fruit by melatonin treatment.  Food Chemistry-X,  14  (100297).  [PMID:35372825]
19. Xueqin Hou, Xinyu Qiu, Yaping Wang, Shuangshuang Song, Yifan Cong, Jifu Hao.  (2022)  Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice.  Oxidative Medicine and Cellular Longevity,  2022  (7135125).  [PMID:35300175]
20. Huizhen Deng, Jie Zhao, Shifan Zhao, Shuai Jiang, Guofeng Cui.  (2022)  A graphene-based electrochemical flow analysis device for simultaneous determination of dopamine, 5-hydroxytryptamine, and melatonin.  ANALYST,  147  (8): (1598-1610).  [PMID:35294958]
21. Ranran Xu, Limin Wang, Kexin Li, Jiankang Cao, Zhilei Zhao.  (2022)  Integrative transcriptomic and metabolomic alterations unravel the effect of melatonin on mitigating postharvest chilling injury upon plum (cv.Friar) fruit.  POSTHARVEST BIOLOGY AND TECHNOLOGY,  186  (111819).  [PMID:]
22. Man Zhang, Yang Bai, Chang Xu, Jinti Lin, JiaKang Jin, Ankai Xu, Jia Nan Lou, Chao Qian, Wei Yu, Yulian Wu, Yiying Qi, Huimin Tao.  (2021)  Novel optimized drug delivery systems for enhancing spinal cord injury repair in rats.  DRUG DELIVERY,  28  (1): (2548-2561).  [PMID:34854786]
23. Huaxu Zhou, Xinyu Ma, Ajabkhan Sailjoi, Yanqi Zou, Xingyu Lin, Fei Yan, Bin Su, Jiyang Liu.  (2022)  Vertical silica nanochannels supported by nanocarbon composite for simultaneous detection of serotonin and melatonin in biological fluids.  SENSORS AND ACTUATORS B-CHEMICAL,  353  (131101).  [PMID:]
24. Hu Jingbo, Tan Xueying, Wang Dongwei, Li Yixuan, Liang Hongze, Peng Jiejun, Li Fengyan, Zhou Quan, Geng Peiwu, Wang Shuanghu, Yu Yue, Liu Jin.  (2021)  RETRACTED ARTICLE: A stepwise-targeting strategy for the treatment of cerebral ischemic stroke.  JOURNAL OF NANOBIOTECHNOLOGY,  19  (1): (1-17).  [PMID:34789285]

References

1. Carlberg C.  (2000)  Gene regulation by melatonin..  Ann N Y Acad Sci,  917  (3): (387-96).  [PMID:11268365]
2. Huang SH, Cao XJ, Wei W.  (2008)  Melatonin decreases TLR3-mediated inflammatory factor expression via inhibition of NF-kappa B activation in respiratory syncytial virus-infected RAW264.7 macrophages..  J Pineal Res,  45  (1): (93-100).  [PMID:18312297]
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