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SKU | Size | Availability | Price | Qty |
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M646879-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $150.90 | |
M646879-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $250.90 | |
M646879-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $550.90 | |
M646879-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $950.90 | |
M646879-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,550.90 |
Specifications & Purity | ≥98% |
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Biochemical and Physiological Mechanisms | MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC 50 and a K i of 3 nM and 0.39 nM, respectively. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC 50 and a K i of 3 nM and 0.39 nM, respectively. Form:Solid IC50& Target:IC50: 3 nM (MELK) Ki: 0.39 nM (MELK) |
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IUPAC Name | methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-5-carboxylate |
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INCHI | InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-19-22(31(39)40-3)9-14-26(25)33-30(28)38/h4-14,19,33,38H,15-18,20H2,1-3H3 |
InChi Key | XIMRJNBUWJTLAL-UHFFFAOYSA-N |
Canonical SMILES | CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=C(C=C5)C(=O)OC)O |
Isomeric SMILES | CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=C(C=C5)C(=O)OC)O |
PubChem CID | 137248544 |
Molecular Weight | 539.62 |
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Solubility | DMSO : 1 mg/mL (1.85 mM; ultrasonic and warming and heat to 60°C) |
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