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MELK-TI , CAS No.M611784, Inhibitor of calcium/calmodulin-dependent protein kinase II delta subunit;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of MAPK interacting serine/threonine kinase 2;Inhibitor of maternal embryonic leucine zipper kinase

Moligand™

PubChem CID: 73442760

Item Number

M611784

Grouped product items
SKU	Size	Availability	Price	Qty
M611784-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M611784-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

calcium/calmodulin-dependent protein kinase II delta subunit Inhibitor fms related receptor tyrosine kinase 3 Inhibitor MAPK interacting serine/threonine kinase 2 Inhibitor maternal embryonic leucine zipper kinase Inhibitor

Basic Description

Synonyms	compound 7
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of calcium/calmodulin-dependent protein kinase II delta subunit;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of MAPK interacting serine/threonine kinase 2;Inhibitor of maternal embryonic leucine zipper kinase

Associated Targets

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 1 Activities

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MELK Tchem Maternal embryonic leucine zipper kinase 1 Activities

Discover Target: MELK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MKNK2 Tchem MAP kinase-interacting serine/threonine-protein kinase 2 1 Activities

Discover Target: MKNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKAA1 Tclin 5'-AMP-activated protein kinase catalytic subunit alpha-1 0 Activities

Discover Target: PRKAA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKAA2 Tchem 5'-AMP-activated protein kinase catalytic subunit alpha-2 0 Activities

Discover Target: PRKAA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CAMK2D Tchem Calcium/calmodulin-dependent protein kinase type II subunit delta 1 Activities

Discover Target: CAMK2D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CAMK2G Tchem Calcium/calmodulin-dependent protein kinase type II subunit gamma 0 Activities

Discover Target: CAMK2G

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MYLK Tchem Myosin light chain kinase, smooth muscle 0 Activities

Discover Target: MYLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide
INCHI	InChI=1S/C21H22N4O2/c1-27-20-11-15(17-12-23-24-13-17)3-5-19(20)21(26)25-18-4-2-14-6-8-22-9-7-16(14)10-18/h2-5,10-13,22H,6-9H2,1H3,(H,23,24)(H,25,26)
InChi Key	GMZCYCKIXQZORP-UHFFFAOYSA-N
Canonical SMILES	COc1cc(ccc1C(=O)Nc1ccc2c(c1)CCNCC2)c1cn[nH]c1
Isomeric SMILES	COC1=C(C=CC(=C1)C2=CNN=C2)C(=O)NC3=CC4=C(CCNCC4)C=C3
PubChem CID	73442760

PubChem CID

73442760

ChEMBL Ligand

CHEMBL3355059

BindingDB Ligand

50043341

References

1. Beke L, Kig C, Linders JT, Boens S, Boeckx A, van Heerde E, Parade M, De Bondt A, Van den Wyngaert I, Bashir T et al.. (2015) MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.. Biosci Rep, 35 (6): (e00267). [PMID:26431963]

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