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Meloxicam - ≥98%, high purity , CAS No.71125-38-7, Inhibitor of COX-1;Inhibitor of COX-2

19 Citations

Moligand™

≥98%

CAS#: 71125-38-7
Formula: C₁₄H₁₃N₃O₄S₂
Molecular Weight: 351.4
MDL number: MFCD00868752
PubChem CID: 54677470

Item Number

M129228

Grouped product items
SKU	Size	Availability	Price
M129228-5g	5g	In stock	$46.90
M129228-10g	10g	In stock	$83.90
M129228-25g	25g	In stock	$136.90
M129228-100g	100g	In stock	$492.90

Nonsteroidal anti-inflammatory drug (NSAID)

View related series

COX COX-1 Inhibitor COX-2 Inhibitor Immunology/Inflammation Metabolic Enzyme/Protease MMP

Basic Description

Synonyms	UH-AC 62XX \| Meloxicam (JAN/USP/INN) \| Meloxoral \| MLS006011422 \| QMIIZ ODT \| AMOXICILLIN CRYSTALLINE \| C14H13N3O4S2 \| MELOXICAM [EP MONOGRAPH] \| Meloxicam Solution for Injection \| VG2QF83CGL \| Vivlodex \| BIDD:GT0726 \| Emdocam \| Movatec \| Parocin \| Metaca
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Meloxicam, a non-steroidal anti-inflammatory agent, has been reported to inhibit the inducible isoform of Cox-2. Meloxicam is an inhibitor selective for Cox-2 (IC50 of 4.7 μM) over Cox-1 (IC50 of 36.6 μM). Studies suggest that Meloxicam is Cox-2 preferent
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of COX-1;Inhibitor of COX-2
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Meloxicam (Mobic) is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects. An inhibitor of Cox-1 and Cox-2, selective for Cox-2.

Associated Targets(Human)

PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (6 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-carboxamide
INCHI	InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)
InChi Key	ZRVUJXDFFKFLMG-UHFFFAOYSA-N
Canonical SMILES	CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O
Isomeric SMILES	CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O
RTECS	DL0702000
PubChem CID	54677470
UN Number	2811
Packing Group	III
Molecular Weight	351.4
Reaxy-Rn	5886369

Database links

DrugBank Ligand	DB00814
PubChem CID	54677470
CAS Registry No.	71125-38-7
ChEMBL Ligand	CHEMBL599
Wikipedia	Meloxicam
RCSB PDB Ligand	MXM
PEP	meloxicam
DrugCentral Ligand	1676

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
K2217942	Certificate of Analysis	Sep 14, 2024	M129228
K2217985	Certificate of Analysis	Sep 14, 2024	M129228
K2217986	Certificate of Analysis	Sep 14, 2024	M129228
K2217988	Certificate of Analysis	Sep 14, 2024	M129228
L2409105	Certificate of Analysis	Sep 14, 2024	M129228
D2422191	Certificate of Analysis	Mar 26, 2024	M129228
D2422192	Certificate of Analysis	Mar 26, 2024	M129228
G1515087	Certificate of Analysis	May 09, 2023	M129228
D2117281	Certificate of Analysis	Feb 08, 2023	M129228
D2117285	Certificate of Analysis	Feb 08, 2023	M129228

Chemical and Physical Properties

Solubility	H2O: 0.67 mg/mL (1.91 mM; ultrasound assisted dissolution); DMSO: 25 mg/mL (71.14 mM; ultrasound assisted dissolution (<60 ° C); Ethanol:<1 mg/mL
Sensitivity	Heat sensitive
Melt Point(°C)	255°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H412:Harmful to aquatic life with long lasting effects H360:May damage fertility or the unborn child
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice.
RTECS	DL0702000
Reaxy-Rn	5886369
Class	6.1
Merck Index	5826

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen. (2023) A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation. BIOMEDICINE & PHARMACOTHERAPY, 168 (115641). [PMID:37806085] [10.1016/j.biopha.2023.115641]
2. Zhong-Xia Wang, Kai-Qi Liu, Xiang-Ying Meng, Feng Li, Heng-Ye Li, Hang Gao, Wei Wang. (2023) An eco-friendly fluorometric assay for high-sensitive meloxicam quantitation in biological matrices. ANALYST, 148 (18): (4339-4345). [PMID:37580992] [10.1039/D3AN01211E]
3. Meizhu Qin, Xinping Hu, Jingyan Guo. (2023) Preparation of a New Type of Expansion Flame Retardant and Application in Polystyrene. Coatings, 13 (4): (733). [PMID:] [10.3390/coatings13040733]
4. Jiana Lin, Xiaoyan Ouyang, Yuling Hu, Gongke Li, Qisheng Zhong. (2023) Primary amide-functionalized cyclotricatechylene covalent organic frameworks membrane for efficient enrichment of melamine and its derivatives in migration solution of food contact materials. JOURNAL OF SEPARATION SCIENCE, 46 (6): (202200862). [PMID:36680331] [10.1002/jssc.202200862]
5. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Yufeng Li, Feng Yun, Rongqian Wu. (2022) UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice. Microbiology Spectrum, [PMID:36453911] [10.1128/spectrum.03424-22]
6. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Jia Zhang, Tao Wang, Pengkang Chang, Yi Lv, Rongqian Wu. (2022) Antibacterial and Antifungal Properties of a Novel Antimicrobial Peptide GK-19 and Its Application in Skin and Soft Tissue Infections Induced by MRSA or Candida albicans. Pharmaceutics, 14 (9): (1937). [PMID:36145681] [10.3390/pharmaceutics14091937]
7. Xiaochun Hu, Yuqing Luo, Xianyue Wu, Jiabin Niu, Mingwu Tan, Zhiqiang Sun, Wen Liu. (2022) Heteroatom-doped microporous carbon nanosheets derived from pentaerythritol-melamine for supercapacitors and CO2 capture. Materials Today Energy, 27 (101010). [PMID:] [10.1016/j.mtener.2022.101010]
8. Ya Xu, Ru Zhou, Jingjing Mu, Yanming Ding, Juncheng Jiang. (2022) Synergistic flame retardancy of linear low-density polyethylene with surface modified intumescent flame retardant and zinc borate. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 640 (128400). [PMID:] [10.1016/j.colsurfa.2022.128400]
9. Xiaoqiang Feng, Zhengyi He, Lingyan Yu, Zhiduo Liu, Gang Wang, Siwei Yang, Guqiao Ding. (2021) Dual-enhanced Raman scattering sensors incorporating graphene plasmonic nanoresonators. Journal of Materials Chemistry C, 9 (37): (12768-12777). [PMID:] [10.1039/D1TC02461B]
10. Wei Zhu, Xiaoqiang Feng, Zhiduo Liu, Menghan Zhao, Peng He, Siwei Yang, Shiwei Tang, Da Chen, Qinglei Guo, Gang Wang, Guqiao Ding. (2021) Sensitive, Reusable, Surface-Enhanced Raman Scattering Sensors Constructed with a 3D Graphene/Si Hybrid. ACS Applied Materials & Interfaces, 13 (19): (23081–23091). [PMID:33957757] [10.1021/acsami.1c02182]
11. Ru Zhou, Jingjing Mu, Xiaoyan Sun, Yanming Ding, Juncheng Jiang. (2020) Application of intumescent flame retardant containing aluminum diethyphosphinate, neopentyl glycol, and melamine for polyethylene. SAFETY SCIENCE, 131 (104849). [PMID:] [10.1016/j.ssci.2020.104849]
12. Chen Xiao, Xi Zhiyu, Liang Huaibin, Sun Yuhao, Zhong Zhihong, Wang Baofeng, Bian Liuguan, Sun Qingfang. (2019) Melatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling in vitro. Frontiers in Neuroscience, 13 [PMID:31404262] [10.3389/fnins.2019.00760]
13. Tong Wang, Hai-Long Wu, Yong-Jie Yu, Wan-Jun Long, Li Cheng, An-Qi Chen, Ru-Qin Yu. (2019) A simple method for direct modeling of second-order liquid chromatographic data with retention time shifts and holding the second-order advantage. JOURNAL OF CHROMATOGRAPHY A, 1605 (360360). [PMID:31326090] [10.1016/j.chroma.2019.07.014]
14. Shouwu Yu, Shujuan Xiao, Zewen Zhao, Xiaowen Huo, Junfu Wei. (2019) Microencapsulated ammonium polyphosphate by polyurethane with segment of dipentaerythritol and its application in flame retardant polypropylene. CHINESE JOURNAL OF CHEMICAL ENGINEERING, 27 (1735). [PMID:] [10.1016/j.cjche.2019.04.023]
15. Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi, Myung Joo Kang. (2016) Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection. Drug Design Development and Therapy, [PMID:27895468] [10.2147/DDDT.S118145]
16. Wang Yu, Gao Lei, Qin Dongli, Chen Ligang. (2017) Analysis of Melamine in Milk Powder by CNT-MIP with Matrix Solid Phase Dispersion and LC-MS/MS. Food Analytical Methods, 10 (5): (1386-1396). [PMID:] [10.1007/s12161-016-0705-1]
17. Kim Han Sol, Cho Ha Ra, Ho Myoung Jin, Kang Myung Joo, Choi Yong Seok. (2016) Determination of piroxicam from rat articular tissue and plasma based on LC–MS/MS. ARCHIVES OF PHARMACAL RESEARCH, 39 (12): (1653-1662). [PMID:27752829] [10.1007/s12272-016-0845-2]
18. Rongli Zhang, Sheng Xu, Ye Zhu, Wei Zhao, Jing Luo, Xiaoya Liu, Dingxing Tang. (2016) Molecularly imprinted nanohybrids based on dopamine-modified poly(γ-glutamic acid) for electrochemical sensing of melamine. BIOSENSORS & BIOELECTRONICS, 85 (381). [PMID:27196255] [10.1016/j.bios.2016.05.030]
19. Xu Xiuzhu, Chen Shuixia, Zhuang Linzhou, Zheng Chunhao, Wu Yingzhu. (2014) Establishment of a novel surface-imprinting system for melamine recognition and mechanism of template–matrix interactions. JOURNAL OF MATERIALS SCIENCE, 49 (7): (2853-2863). [PMID:] [10.1007/s10853-013-7991-4]

References

1. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen. (2023) A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation. BIOMEDICINE & PHARMACOTHERAPY, 168 (115641). [PMID:37806085] [10.1016/j.biopha.2023.115641]
2. Zhong-Xia Wang, Kai-Qi Liu, Xiang-Ying Meng, Feng Li, Heng-Ye Li, Hang Gao, Wei Wang. (2023) An eco-friendly fluorometric assay for high-sensitive meloxicam quantitation in biological matrices. ANALYST, 148 (18): (4339-4345). [PMID:37580992] [10.1039/D3AN01211E]
3. Meizhu Qin, Xinping Hu, Jingyan Guo. (2023) Preparation of a New Type of Expansion Flame Retardant and Application in Polystyrene. Coatings, 13 (4): (733). [PMID:] [10.3390/coatings13040733]
4. Jiana Lin, Xiaoyan Ouyang, Yuling Hu, Gongke Li, Qisheng Zhong. (2023) Primary amide-functionalized cyclotricatechylene covalent organic frameworks membrane for efficient enrichment of melamine and its derivatives in migration solution of food contact materials. JOURNAL OF SEPARATION SCIENCE, 46 (6): (202200862). [PMID:36680331] [10.1002/jssc.202200862]
5. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Yufeng Li, Feng Yun, Rongqian Wu. (2022) UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice. Microbiology Spectrum, [PMID:36453911] [10.1128/spectrum.03424-22]
6. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Jia Zhang, Tao Wang, Pengkang Chang, Yi Lv, Rongqian Wu. (2022) Antibacterial and Antifungal Properties of a Novel Antimicrobial Peptide GK-19 and Its Application in Skin and Soft Tissue Infections Induced by MRSA or Candida albicans. Pharmaceutics, 14 (9): (1937). [PMID:36145681] [10.3390/pharmaceutics14091937]
7. Xiaochun Hu, Yuqing Luo, Xianyue Wu, Jiabin Niu, Mingwu Tan, Zhiqiang Sun, Wen Liu. (2022) Heteroatom-doped microporous carbon nanosheets derived from pentaerythritol-melamine for supercapacitors and CO2 capture. Materials Today Energy, 27 (101010). [PMID:] [10.1016/j.mtener.2022.101010]
8. Ya Xu, Ru Zhou, Jingjing Mu, Yanming Ding, Juncheng Jiang. (2022) Synergistic flame retardancy of linear low-density polyethylene with surface modified intumescent flame retardant and zinc borate. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 640 (128400). [PMID:] [10.1016/j.colsurfa.2022.128400]
9. Xiaoqiang Feng, Zhengyi He, Lingyan Yu, Zhiduo Liu, Gang Wang, Siwei Yang, Guqiao Ding. (2021) Dual-enhanced Raman scattering sensors incorporating graphene plasmonic nanoresonators. Journal of Materials Chemistry C, 9 (37): (12768-12777). [PMID:] [10.1039/D1TC02461B]
10. Wei Zhu, Xiaoqiang Feng, Zhiduo Liu, Menghan Zhao, Peng He, Siwei Yang, Shiwei Tang, Da Chen, Qinglei Guo, Gang Wang, Guqiao Ding. (2021) Sensitive, Reusable, Surface-Enhanced Raman Scattering Sensors Constructed with a 3D Graphene/Si Hybrid. ACS Applied Materials & Interfaces, 13 (19): (23081–23091). [PMID:33957757] [10.1021/acsami.1c02182]
11. Ru Zhou, Jingjing Mu, Xiaoyan Sun, Yanming Ding, Juncheng Jiang. (2020) Application of intumescent flame retardant containing aluminum diethyphosphinate, neopentyl glycol, and melamine for polyethylene. SAFETY SCIENCE, 131 (104849). [PMID:] [10.1016/j.ssci.2020.104849]
12. Chen Xiao, Xi Zhiyu, Liang Huaibin, Sun Yuhao, Zhong Zhihong, Wang Baofeng, Bian Liuguan, Sun Qingfang. (2019) Melatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling in vitro. Frontiers in Neuroscience, 13 [PMID:31404262] [10.3389/fnins.2019.00760]
13. Tong Wang, Hai-Long Wu, Yong-Jie Yu, Wan-Jun Long, Li Cheng, An-Qi Chen, Ru-Qin Yu. (2019) A simple method for direct modeling of second-order liquid chromatographic data with retention time shifts and holding the second-order advantage. JOURNAL OF CHROMATOGRAPHY A, 1605 (360360). [PMID:31326090] [10.1016/j.chroma.2019.07.014]
14. Shouwu Yu, Shujuan Xiao, Zewen Zhao, Xiaowen Huo, Junfu Wei. (2019) Microencapsulated ammonium polyphosphate by polyurethane with segment of dipentaerythritol and its application in flame retardant polypropylene. CHINESE JOURNAL OF CHEMICAL ENGINEERING, 27 (1735). [PMID:] [10.1016/j.cjche.2019.04.023]
15. Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi, Myung Joo Kang. (2016) Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection. Drug Design Development and Therapy, [PMID:27895468] [10.2147/DDDT.S118145]
16. Wang Yu, Gao Lei, Qin Dongli, Chen Ligang. (2017) Analysis of Melamine in Milk Powder by CNT-MIP with Matrix Solid Phase Dispersion and LC-MS/MS. Food Analytical Methods, 10 (5): (1386-1396). [PMID:] [10.1007/s12161-016-0705-1]
17. Kim Han Sol, Cho Ha Ra, Ho Myoung Jin, Kang Myung Joo, Choi Yong Seok. (2016) Determination of piroxicam from rat articular tissue and plasma based on LC–MS/MS. ARCHIVES OF PHARMACAL RESEARCH, 39 (12): (1653-1662). [PMID:27752829] [10.1007/s12272-016-0845-2]
18. Rongli Zhang, Sheng Xu, Ye Zhu, Wei Zhao, Jing Luo, Xiaoya Liu, Dingxing Tang. (2016) Molecularly imprinted nanohybrids based on dopamine-modified poly(γ-glutamic acid) for electrochemical sensing of melamine. BIOSENSORS & BIOELECTRONICS, 85 (381). [PMID:27196255] [10.1016/j.bios.2016.05.030]
19. Xu Xiuzhu, Chen Shuixia, Zhuang Linzhou, Zheng Chunhao, Wu Yingzhu. (2014) Establishment of a novel surface-imprinting system for melamine recognition and mechanism of template–matrix interactions. JOURNAL OF MATERIALS SCIENCE, 49 (7): (2853-2863). [PMID:] [10.1007/s10853-013-7991-4]

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