Meloxicam - ≥98%, high purity , CAS No.71125-38-7, Inhibitor of COX-1;Inhibitor of COX-2

8 Citations
Item Number
M129228
Grouped product items
SKUSizeAvailabilityPrice Qty
M129228-5g
5g
In stock
$46.90
M129228-10g
10g
In stock
$83.90
M129228-25g
25g
In stock
$136.90
M129228-100g
100g
In stock
$492.90

Nonsteroidal anti-inflammatory drug (NSAID)

View related series
COX-1 Inhibitor COX-2 Inhibitor

Basic Description

SynonymsUH-AC 62XX | Meloxicam (JAN/USP/INN) | Meloxoral | MLS006011422 | QMIIZ ODT | AMOXICILLIN CRYSTALLINE | C14H13N3O4S2 | MELOXICAM [EP MONOGRAPH] | Meloxicam Solution for Injection | VG2QF83CGL | Vivlodex | BIDD:GT0726 | Emdocam | Movatec | Parocin | Metaca
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsMeloxicam, a non-steroidal anti-inflammatory agent, has been reported to inhibit the inducible isoform of Cox-2. Meloxicam is an inhibitor selective for Cox-2 (IC50 of 4.7 μM) over Cox-1 (IC50 of 36.6 μM). Studies suggest that Meloxicam is Cox-2 preferent
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of COX-1;Inhibitor of COX-2
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Meloxicam (Mobic) is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects.
An inhibitor of Cox-1 and Cox-2, selective for Cox-2.

Associated Targets(Human)

PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS2 Tclin Prostaglandin G/H synthase 2 (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-carboxamide
INCHI InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)
InChi Key ZRVUJXDFFKFLMG-UHFFFAOYSA-N
Canonical SMILES CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O
Isomeric SMILES CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O
RTECS DL0702000
PubChem CID 54677470
UN Number 2811
Packing Group III
Molecular Weight 351.4
Reaxy-Rn 5886369

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
D2422191Certificate of AnalysisMar 26, 2024 M129228
D2422192Certificate of AnalysisMar 26, 2024 M129228
G1515087Certificate of AnalysisMay 09, 2023 M129228
D2117281Certificate of AnalysisFeb 08, 2023 M129228
D2117285Certificate of AnalysisFeb 08, 2023 M129228
K2217942Certificate of AnalysisOct 31, 2022 M129228
K2217985Certificate of AnalysisOct 31, 2022 M129228
K2217986Certificate of AnalysisOct 31, 2022 M129228
K2217988Certificate of AnalysisOct 31, 2022 M129228

Chemical and Physical Properties

SolubilityH2O: 0.67 mg/mL (1.91 mM; ultrasound assisted dissolution); DMSO: 25 mg/mL (71.14 mM; ultrasound assisted dissolution (<60 ° C); Ethanol:<1 mg/mL
SensitivityHeat sensitive
Melt Point(°C)255°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H412:Harmful to aquatic life with long lasting effects

H360:May damage fertility or the unborn child

Precautionary Statements

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P318:if exposed or concerned, get medical advice.

RTECS DL0702000
Reaxy-Rn 5886369
Class 6.1
Merck Index 5826

Related Documents

Citations of This Product

1. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen.  (2023)  A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation.  BIOMEDICINE & PHARMACOTHERAPY,  168  (115641).  [PMID:37806085]
2. Zhong-Xia Wang, Kai-Qi Liu, Xiang-Ying Meng, Feng Li, Heng-Ye Li, Hang Gao, Wei Wang.  (2023)  An eco-friendly fluorometric assay for high-sensitive meloxicam quantitation in biological matrices.  ANALYST,  148  (18): (4339-4345).  [PMID:37580992]
3. Meizhu Qin, Xinping Hu, Jingyan Guo.  (2023)  Preparation of a New Type of Expansion Flame Retardant and Application in Polystyrene.  Coatings,  13  (4): (733).  [PMID:]
4. Jiana Lin, Xiaoyan Ouyang, Yuling Hu, Gongke Li, Qisheng Zhong.  (2023)  Primary amide-functionalized cyclotricatechylene covalent organic frameworks membrane for efficient enrichment of melamine and its derivatives in migration solution of food contact materials.  JOURNAL OF SEPARATION SCIENCE,  46  (6): (202200862).  [PMID:36680331]
5. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Yufeng Li, Feng Yun, Rongqian Wu.  (2022)  UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice.  Microbiology Spectrum,      [PMID:36453911]
6. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Jia Zhang, Tao Wang, Pengkang Chang, Yi Lv, Rongqian Wu.  (2022)  Antibacterial and Antifungal Properties of a Novel Antimicrobial Peptide GK-19 and Its Application in Skin and Soft Tissue Infections Induced by MRSA or Candida albicans.  Pharmaceutics,  14  (9): (1937).  [PMID:36145681]
7. Xiaochun Hu, Yuqing Luo, Xianyue Wu, Jiabin Niu, Mingwu Tan, Zhiqiang Sun, Wen Liu.  (2022)  Heteroatom-doped microporous carbon nanosheets derived from pentaerythritol-melamine for supercapacitors and CO2 capture.  Materials Today Energy,  27  (101010).  [PMID:]
8. Ya Xu, Ru Zhou, Jingjing Mu, Yanming Ding, Juncheng Jiang.  (2022)  Synergistic flame retardancy of linear low-density polyethylene with surface modified intumescent flame retardant and zinc borate.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  640  (128400).  [PMID:]

References

1. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen.  (2023)  A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation.  BIOMEDICINE & PHARMACOTHERAPY,  168  (115641).  [PMID:37806085]
2. Zhong-Xia Wang, Kai-Qi Liu, Xiang-Ying Meng, Feng Li, Heng-Ye Li, Hang Gao, Wei Wang.  (2023)  An eco-friendly fluorometric assay for high-sensitive meloxicam quantitation in biological matrices.  ANALYST,  148  (18): (4339-4345).  [PMID:37580992]
3. Meizhu Qin, Xinping Hu, Jingyan Guo.  (2023)  Preparation of a New Type of Expansion Flame Retardant and Application in Polystyrene.  Coatings,  13  (4): (733).  [PMID:]
4. Jiana Lin, Xiaoyan Ouyang, Yuling Hu, Gongke Li, Qisheng Zhong.  (2023)  Primary amide-functionalized cyclotricatechylene covalent organic frameworks membrane for efficient enrichment of melamine and its derivatives in migration solution of food contact materials.  JOURNAL OF SEPARATION SCIENCE,  46  (6): (202200862).  [PMID:36680331]
5. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Yufeng Li, Feng Yun, Rongqian Wu.  (2022)  UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice.  Microbiology Spectrum,      [PMID:36453911]
6. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Jia Zhang, Tao Wang, Pengkang Chang, Yi Lv, Rongqian Wu.  (2022)  Antibacterial and Antifungal Properties of a Novel Antimicrobial Peptide GK-19 and Its Application in Skin and Soft Tissue Infections Induced by MRSA or Candida albicans.  Pharmaceutics,  14  (9): (1937).  [PMID:36145681]
7. Xiaochun Hu, Yuqing Luo, Xianyue Wu, Jiabin Niu, Mingwu Tan, Zhiqiang Sun, Wen Liu.  (2022)  Heteroatom-doped microporous carbon nanosheets derived from pentaerythritol-melamine for supercapacitors and CO2 capture.  Materials Today Energy,  27  (101010).  [PMID:]
8. Ya Xu, Ru Zhou, Jingjing Mu, Yanming Ding, Juncheng Jiang.  (2022)  Synergistic flame retardancy of linear low-density polyethylene with surface modified intumescent flame retardant and zinc borate.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  640  (128400).  [PMID:]

Solution Calculators