Basic Description

Synonyms	AKOS016352717 \| DTXCID8020547 \| FT-0633931 \| Hemoklot \| Sepisol \| 2-Methyl-1,4-naphthochinon-natrium-bisulfit trihydrat \| Menadione bisulfite sodium \| Menadione sodium bisulfite [INN] \| SHB 264AB \| 1,2,3,4-Tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfon
Specifications & Purity	BioReagent, for cell culture, ≥95%(TLC)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	BioReagent, for cell culture
Note	Water soluble vitamin K3.
Product Description	Description Use in cell culture to induce oxidative stress for mechanistic studies.

Associated Targets(Human)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cenchrus americanus (77 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	sodium;2-methyl-1,4-dioxo-3H-naphthalene-2-sulfonate
INCHI	InChI=1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1
InChi Key	XDPFHGWVCTXHDX-UHFFFAOYSA-M
Canonical SMILES	CC1(CC(=O)C2=CC=CC=C2C1=O)S(=O)(=O)[O-].[Na+]
Isomeric SMILES	CC1(CC(=O)C2=CC=CC=C2C1=O)S(=O)(=O)[O-].[Na+]
PubChem CID	23665888
Molecular Weight	276.24

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	water: soluble 50mg/mL, clear, colorless to light yellow
Melt Point(°C)	121-124°C

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.

References

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22. Yu Jiang,Jingbo Yang,Chunhui Yang,Fanmin Meng,Yongfeng Zhou,Bo Yu,Muhammad Khan,Hong Yang. (2013-07-24) Vitamin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathway.. Die Pharmazie, 68 ((6)): (442-448). [PMID:23875252]
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24. Melissa A Dean,Randall J Olsen,S Wesley Long,Adriana E Rosato,James M Musser. (2014-01-24) Identification of point mutations in clinical Staphylococcus aureus strains that produce small-colony variants auxotrophic for menadione.. Infection and immunity, 82 ((4)): (1600-1605). [PMID:24452687]
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Menadione sodium bisulfite - BioReagent, suitable for cell culture, ≥95% (TLC), high purity , CAS No.130-37-0