MeOSuc-AAPV-CMK - ≥98%, high purity , CAS No.65144-34-5

Item Number

S274813

Grouped product items
SKU	Size	Availability	Price
S274813-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$159.90
S274813-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$259.90
S274813-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$519.90

Potent, irreversible HLE inhibitor

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Basic Description

Synonyms	Elastase Inhibitor III \| N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone \| N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine chloromethylketone
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is a tetrapeptide, cell-permeable and non-cytotoxic inhibitor.

Names and Identifiers

IUPAC Name	methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
INCHI	InChI=1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,26,32)/t13-,14-,15-,19-/m0/s1
InChi Key	PJGDFLJMBAYGGC-XLPNERPQSA-N
Canonical SMILES	CC(C)C(C(=O)CCl)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(C)NC(=O)CCC(=O)OC
Isomeric SMILES	C[C@@H](C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)CCl)NC(=O)CCC(=O)OC
PubChem CID	5486692
Molecular Weight	502.99

Certificates

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6 results found

Lot Number	Certificate Type	Date	Item
H2406490	Certificate of Analysis	Jul 24, 2024	S274813
H2406491	Certificate of Analysis	Jul 24, 2024	S274813
H2406492	Certificate of Analysis	Jul 24, 2024	S274813
H2406493	Certificate of Analysis	Jul 24, 2024	S274813
H2406494	Certificate of Analysis	Jul 24, 2024	S274813
H2406496	Certificate of Analysis	Jul 24, 2024	S274813

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Basic Description