Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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M126858-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $53.90 | |
M126858-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $243.90 | |
M126858-1g | 1g | In stock | $874.90 | |
M126858-5g | 5g | In stock | $3,936.90 | |
M126858-10g | 10g | In stock | $7,085.90 | |
M126858-25g | 25g | In stock | $15,943.90 | |
M126858-100g | 100g | In stock | $57,395.90 |
Purine analog; inhibits DNA and RNA synthesis
Synonyms | 6-MP | 7-Mercapto-1,3,4,6-tetrazaindene | CHEBI:50667 | Mercaptopurine [USAN:USP:INN] | NCIMech_000025 | Purine-6(1H)-thione | Purinethiol | AZATHIOPRINE IMPURITY B (EP IMPURITY) | Spectrum5_000950 | 1H-purine-6(7H)-thione. | 6H-Purine-6-thione, 1,2,3,9-t |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Inhibitor ofde novopurine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite ofazathioprine. Also inhibits SARS-CoV papain-like protease ( |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Description: |
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Pubchem Sid | 488191019 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488191019 |
IUPAC Name | 3,7-dihydropurine-6-thione |
INCHI | InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) |
InChi Key | GLVAUDGFNGKCSF-UHFFFAOYSA-N |
Canonical SMILES | C1=NC2=C(N1)C(=S)N=CN2 |
Isomeric SMILES | C1=NC2=C(N1)C(=S)N=CN2 |
PubChem CID | 667490 |
Molecular Weight | 152.18 |
DrugBank Ligand | DB01033 |
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PubChem CID | 667490 |
CAS Registry No. | 50-44-2 |
ChEMBL Ligand | CHEMBL1425 |
Wikipedia | Mercaptopurine |
RCSB PDB Ligand | PM6 |
PEP | 6-mercaptopurine |
DrugCentral Ligand | 1708 |
PubChem SID | 488191019 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K1827074 | Certificate of Analysis | Apr 07, 2024 | M126858 |
G23151005 | Certificate of Analysis | Jul 31, 2023 | M126858 |
G2315925 | Certificate of Analysis | Jul 31, 2023 | M126858 |
G2315930 | Certificate of Analysis | Jul 31, 2023 | M126858 |
G2315933 | Certificate of Analysis | Jul 31, 2023 | M126858 |
G2315934 | Certificate of Analysis | Jul 31, 2023 | M126858 |
G2315937 | Certificate of Analysis | Jul 31, 2023 | M126858 |
G2315938 | Certificate of Analysis | Jul 31, 2023 | M126858 |
G2315939 | Certificate of Analysis | Jul 31, 2023 | M126858 |
G2315940 | Certificate of Analysis | Jul 31, 2023 | M126858 |
G2315944 | Certificate of Analysis | Jul 31, 2023 | M126858 |
F2307402 | Certificate of Analysis | Mar 15, 2023 | M126858 |
F2111049 | Certificate of Analysis | Jun 22, 2021 | M126858 |
J2220067 | Certificate of Analysis | Jun 22, 2021 | M126858 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 15.22, Max Conc. mM: 100; Solvent:1eq. NaOH, Max Conc. mg/mL: 15.22, Max Conc. mM: 100 |
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Sensitivity | Light sensitive |
Pictogram(s) | GHS06, GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H335:May cause respiratory irritation H301:Toxic if swallowed H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
1. Zhihong Yan, Hong Li. (2015) Voltammetric Determination of 6-mercaptopurine at Co(III) Trisphenanthroline Complex and DNA Decorated with Grpahene Oxide Modified Glassy Carbon Electrode. International Journal of Electrochemical Science, 10 (8714). [PMID:] |
2. Hongyan Lu, Nan Liu, Tongtong Sun, Zhu Liu, Xinyi Luo, Qinfu Zhao, Siling Wang. (2023) Release kinetics study of fatty acids eutectic mixture gated mesoporous carbon nanoparticles for chemo-photothermal therapy. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 669 (131450). [PMID:] |
3. Shanshan Wang, Yan Qin, Qiuyu Wen, Quan Xia, Ruoyu Gu, Sheng Wang, GuanJun Chen, Chao Tan, Chenlin Shen, Shuai Song. (2022) Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration. Drug Metabolism and Pharmacokinetics, 45 (100458). [PMID:35569194] |
4. Yu Zhang, Xin Xu, Bing Yan. (2022) A multicolor-switchable fluorescent lanthanide MOFs triggered by anti-cancer drugs: multifunctional platform for anti-cancer drug sensing and information anticounterfeiting. Journal of Materials Chemistry C, 10 (9): (3576-3584). [PMID:] |
5. Bo Tao,Zongning Yin. (2020-05-20) Redox-Responsive Coordination Polymers of Dopamine-Modified Hyaluronic Acid with Copper and 6-Mercaptopurine for Targeted Drug Delivery and Improvement of Anticancer Activity against Cancer Cells.. Polymers, 12 ((5)): [PMID:32423174] |
6. Jian Dong,Qingfeng Chen,Chunhui Rong,Danyang Li,Yanying Rao. (2011-07-07) Minimally invasive surface-enhanced Raman scattering detection with depth profiles based on a surface-enhanced Raman scattering-active acupuncture needle.. Analytical chemistry, 83 ((16)): (6191-6195). [PMID:21728307] |
1. Zhihong Yan, Hong Li. (2015) Voltammetric Determination of 6-mercaptopurine at Co(III) Trisphenanthroline Complex and DNA Decorated with Grpahene Oxide Modified Glassy Carbon Electrode. International Journal of Electrochemical Science, 10 (8714). [PMID:] |
2. Hongyan Lu, Nan Liu, Tongtong Sun, Zhu Liu, Xinyi Luo, Qinfu Zhao, Siling Wang. (2023) Release kinetics study of fatty acids eutectic mixture gated mesoporous carbon nanoparticles for chemo-photothermal therapy. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 669 (131450). [PMID:] |
3. Shanshan Wang, Yan Qin, Qiuyu Wen, Quan Xia, Ruoyu Gu, Sheng Wang, GuanJun Chen, Chao Tan, Chenlin Shen, Shuai Song. (2022) Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration. Drug Metabolism and Pharmacokinetics, 45 (100458). [PMID:35569194] |
4. Yu Zhang, Xin Xu, Bing Yan. (2022) A multicolor-switchable fluorescent lanthanide MOFs triggered by anti-cancer drugs: multifunctional platform for anti-cancer drug sensing and information anticounterfeiting. Journal of Materials Chemistry C, 10 (9): (3576-3584). [PMID:] |
5. Bo Tao,Zongning Yin. (2020-05-20) Redox-Responsive Coordination Polymers of Dopamine-Modified Hyaluronic Acid with Copper and 6-Mercaptopurine for Targeted Drug Delivery and Improvement of Anticancer Activity against Cancer Cells.. Polymers, 12 ((5)): [PMID:32423174] |
6. Jian Dong,Qingfeng Chen,Chunhui Rong,Danyang Li,Yanying Rao. (2011-07-07) Minimally invasive surface-enhanced Raman scattering detection with depth profiles based on a surface-enhanced Raman scattering-active acupuncture needle.. Analytical chemistry, 83 ((16)): (6191-6195). [PMID:21728307] |