Mercaptopurine (6-MP) - ≥99%, high purity , CAS No.50-44-2

Item Number
M126858
Grouped product items
SKUSizeAvailabilityPrice Qty
M126858-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$53.90
M126858-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$243.90
M126858-1g
1g
In stock
$874.90
M126858-5g
5g
In stock
$3,936.90
M126858-10g
10g
In stock
$7,085.90
M126858-25g
25g
In stock
$15,943.90
M126858-100g
100g
In stock
$57,395.90

Purine analog; inhibits DNA and RNA synthesis

Basic Description

Synonyms6-MP | 7-Mercapto-1,3,4,6-tetrazaindene | CHEBI:50667 | Mercaptopurine [USAN:USP:INN] | NCIMech_000025 | Purine-6(1H)-thione | Purinethiol | AZATHIOPRINE IMPURITY B (EP IMPURITY) | Spectrum5_000950 | 1H-purine-6(7H)-thione. | 6H-Purine-6-thione, 1,2,3,9-t
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsInhibitor ofde novopurine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite ofazathioprine. Also inhibits SARS-CoV papain-like protease (
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Description
6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.6-Mercaptopurine.

Associated Targets(Human)

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pnp Purine nucleoside phosphorylase (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Helicobacter pylori (3113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium avium (4587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycolicibacterium phlei (631 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium avium subsp. paratuberculosis (238 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycolicibacterium smegmatis (8003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Eimeria tenella (990 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania amazonensis (3813 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16 (5829 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHO (4503 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J774.A1 (2436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L1210 (27553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388 (20296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388/ADR (1216 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
WEHI-164 (110 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S49 (59 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C6 (2371 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ehrlich (1318 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J774 (3120 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus anthracis (2936 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania chagasi (396 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TGR Thioredoxin glutathione reductase (28579 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glra2 Glycine receptor (1745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488191019
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488191019
IUPAC Name 3,7-dihydropurine-6-thione
INCHI InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChi Key GLVAUDGFNGKCSF-UHFFFAOYSA-N
Canonical SMILES C1=NC2=C(N1)C(=S)N=CN2
Isomeric SMILES C1=NC2=C(N1)C(=S)N=CN2
PubChem CID 667490
Molecular Weight 152.18

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot NumberCertificate TypeDateItem
K1827074Certificate of AnalysisApr 07, 2024 M126858
G23151005Certificate of AnalysisJul 31, 2023 M126858
G2315925Certificate of AnalysisJul 31, 2023 M126858
G2315930Certificate of AnalysisJul 31, 2023 M126858
G2315933Certificate of AnalysisJul 31, 2023 M126858
G2315934Certificate of AnalysisJul 31, 2023 M126858
G2315937Certificate of AnalysisJul 31, 2023 M126858
G2315938Certificate of AnalysisJul 31, 2023 M126858
G2315939Certificate of AnalysisJul 31, 2023 M126858
G2315940Certificate of AnalysisJul 31, 2023 M126858
G2315944Certificate of AnalysisJul 31, 2023 M126858
F2307402Certificate of AnalysisMar 15, 2023 M126858
F2111049Certificate of AnalysisJun 22, 2021 M126858
J2220067Certificate of AnalysisJun 22, 2021 M126858

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 15.22, Max Conc. mM: 100; Solvent:1eq. NaOH, Max Conc. mg/mL: 15.22, Max Conc. mM: 100
SensitivityLight sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08,   GHS07
Signal Danger
Hazard Statements

H335:May cause respiratory irritation

H301:Toxic if swallowed

H302:Harmful if swallowed

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

Related Documents

Citations of This Product

1. Zhihong Yan, Hong Li.  (2015)  Voltammetric Determination of 6-mercaptopurine at Co(III) Trisphenanthroline Complex and DNA Decorated with Grpahene Oxide Modified Glassy Carbon Electrode.  International Journal of Electrochemical Science,  10  (8714).  [PMID:] [10.1016/S1452-3981(23)11130-8]
2. Hongyan Lu, Nan Liu, Tongtong Sun, Zhu Liu, Xinyi Luo, Qinfu Zhao, Siling Wang.  (2023)  Release kinetics study of fatty acids eutectic mixture gated mesoporous carbon nanoparticles for chemo-photothermal therapy.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  669  (131450).  [PMID:] [10.1016/j.colsurfa.2023.131450]
3. Shanshan Wang, Yan Qin, Qiuyu Wen, Quan Xia, Ruoyu Gu, Sheng Wang, GuanJun Chen, Chao Tan, Chenlin Shen, Shuai Song.  (2022)  Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration.  Drug Metabolism and Pharmacokinetics,  45  (100458).  [PMID:35569194] [10.1016/j.dmpk.2022.100458]
4. Yu Zhang, Xin Xu, Bing Yan.  (2022)  A multicolor-switchable fluorescent lanthanide MOFs triggered by anti-cancer drugs: multifunctional platform for anti-cancer drug sensing and information anticounterfeiting.  Journal of Materials Chemistry C,  10  (9): (3576-3584).  [PMID:] [10.1039/D1TC05935A]
5. Binbin Zhou, Weihui Ou, Chenghao Zhao, Junda Shen, Guobin Zhang, Xianghu Tang, Zhiqin Deng, Guangyu Zhu, Yang Yang Li, Jian Lu.  (2021)  Insertable and reusable SERS sensors for rapid on-site quality control of fish and meat products.  CHEMICAL ENGINEERING JOURNAL,  426  (130733).  [PMID:] [10.1016/j.cej.2021.130733]
6. Bo Tao, Zong-ning Yin.  (2020)  Synthesis of HA-SS-MP: A Prodrug With High Specificity for Cancer Cells.  Natural Product Communications,      [PMID:] [10.1177/1934578X20932761]
7. Yuqian Jiang, Zheng Wang, Wei Duan, Lingyan Liu, Mahan Si, Xiaoyuan Chen, Chen-Jie Fang.  (2020)  The critical size of gold nanoparticles for overcoming P-gp mediated multidrug resistance.  Nanoscale,  12  (31): (16451-16461).  [PMID:32790812] [10.1039/D0NR03226C]
8. Zhang Feng, Liu Hua, Liu Qing, Su Xingguang.  (2018)  An enzymatic ratiometric fluorescence assay for 6-mercaptopurine by using MoS2 quantum dots.  MICROCHIMICA ACTA,  185  (12): (1-8).  [PMID:30415422] [10.1007/s00604-018-3039-4]
9. Deng Hao-Hua, Huang Kai-Yuan, Zhuang Qiong-Qiong, Zhuang Quan-Quan, Peng Hua-Ping, Liu Yin-Huan, Xia Xing-Hua, Chen Wei.  (2018)  Preparation of strongly fluorescent water-soluble dithiothreitol modified gold nanoclusters coated with carboxychitosan, and their application to fluorometric determination of the immunosuppressive 6-mercaptopurine.  MICROCHIMICA ACTA,  185  (8): (1-8).  [PMID:30076470] [10.1007/s00604-018-2933-0]
10. Yang Yang, Shuang Zhou, Ruizhuo Ouyang, Yaoqin Yang, Huihong Tao, Kai Feng, Xiaoshen Zhang, Fei Xiong, Ning Guo, Tianyu Zong, Penghui Cao, Yuhao Li, Yuqing Miao.  (2016)  Improvement in the Anticancer Activity of 6-Mercaptopurine via Combination with Bismuth(III).  CHEMICAL & PHARMACEUTICAL BULLETIN,  64  (11): (1539-1545).  [PMID:27803465] [10.1248/cpb.c15-00949]
11. Lixia Zhang, Hongli Li, Guang Chu, Lan Luo, Jing Jin, Bing Zhao, Yuan Tian.  (2016)  Detection of 6-Mercaptopurine by silver nanowires-coated silicon wafer based on surface-enhanced Raman scattering spectroscopy.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  508  (309).  [PMID:] [10.1016/j.colsurfa.2016.08.069]
12. Yusheng Yuan, Yalan Wang, Shaopu Liu, Yuanfang Li, Ruilin Duan, Hui Zhang, Xiaoli Hu.  (2016)  Fluorescence quenching and spectrophotometric methods for the determination of 6-mercaptopurine based on carbon dots.  RSC Advances,  (57): (52255-52263).  [PMID:] [10.1039/C6RA07675K]
13. Liyan Shi, Kaikai Ding, Xin Sun, Ling Zhang, Tian Zeng, Yihua Yin, Hua Zheng.  (2016)  Preparation, characterization, and in vitro drug release behavior of glutathione-sensitive long-circulation micelles based on polyethylene glycol prodrug.  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,      [PMID:26764973] [10.1080/09205063.2016.1140502]
14. Han Cao, Yuhong Yang, Xin Chen, Zhengzhong Shao.  (2016)  Intelligent Janus nanoparticles for intracellular real-time monitoring of dual drug release.  Nanoscale,  (12): (6754-6760).  [PMID:26952741] [10.1039/C6NR00987E]
15. Ai Ping Li, Jing Dong Peng, MingQiong Zhou, Jin Zhang.  (2016)  Resonance light scattering determination of 6-mercaptopurine coupled with HPLC technique.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  154  (1).  [PMID:26479445] [10.1016/j.saa.2015.09.010]
16. Ke Zeng, Jin Li, Zhaoguo Zhang, Mina Yan, Yunhui Liao, Xuefei Zhang, Chunshun Zhao.  (2015)  Lipid-coated ZnO nanoparticles as lymphatic-targeted drug carriers: study on cell-specific toxicity in vitro and lymphatic targeting in vivo.  Journal of Materials Chemistry B,  (26): (5249-5260).  [PMID:32262600] [10.1039/C5TB00486A]
17. Zhengjuan Sun, Yali Liu, Yuanfang Li.  (2015)  Selective recognition of 6-mercaptopurine based on luminescent metal–organic frameworks Fe-MIL-88NH2.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  139  (296).  [PMID:25574647] [10.1016/j.saa.2014.12.009]
18. Xiao-Yu Gong, Yi-Hua Yin, Zhi-Jun Huang, Bo Lu, Pei-Hu Xu, Hua Zheng, Fu-Liang Xiong, Hai-Xing Xu, Xiong Xiong, Xing-Bao Gu.  (2012)  Preparation, characterization and in vitro release study of a glutathione-dependent polymeric prodrug Cis-3-(9H-purin-6-ylthio)-acrylic acid-graft-carboxymethyl chitosan.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  436  (240).  [PMID:22750430] [10.1016/j.ijpharm.2012.06.043]
19. Xuzhu Zhang, Fang Du, Jin Huang, Wei Lu, Shiyuan Liu, Jiahui Yu.  (2012)  Fabrication of biodegradable micelles with reduction-triggered release of 6-mercaptopurine profile based on disulfide-linked graft copolymer conjugate.  COLLOIDS AND SURFACES B-BIOINTERFACES,  100  (155).  [PMID:22766292] [10.1016/j.colsurfb.2012.04.043]
20. Hua Zheng, Yan Rao, Yihua Yin, Xiong Xiong, Peihu Xu, Bo Lu.  (2011)  Preparation, characterization, and in vitro drug release behavior of 6-mercaptopurine-carboxymethyl chitosan.  CARBOHYDRATE POLYMERS,  83  (1952).  [PMID:] [10.1016/j.carbpol.2010.10.069]
21. Bo Tao,Zongning Yin.  (2020-05-20)  Redox-Responsive Coordination Polymers of Dopamine-Modified Hyaluronic Acid with Copper and 6-Mercaptopurine for Targeted Drug Delivery and Improvement of Anticancer Activity against Cancer Cells..  Polymers,  12  ((5)):   [PMID:32423174]
22. Jian Dong,Qingfeng Chen,Chunhui Rong,Danyang Li,Yanying Rao.  (2011-07-07)  Minimally invasive surface-enhanced Raman scattering detection with depth profiles based on a surface-enhanced Raman scattering-active acupuncture needle..  Analytical chemistry,  83  ((16)): (6191-6195).  [PMID:21728307]

References

1. Zhihong Yan, Hong Li.  (2015)  Voltammetric Determination of 6-mercaptopurine at Co(III) Trisphenanthroline Complex and DNA Decorated with Grpahene Oxide Modified Glassy Carbon Electrode.  International Journal of Electrochemical Science,  10  (8714).  [PMID:] [10.1016/S1452-3981(23)11130-8]
2. Hongyan Lu, Nan Liu, Tongtong Sun, Zhu Liu, Xinyi Luo, Qinfu Zhao, Siling Wang.  (2023)  Release kinetics study of fatty acids eutectic mixture gated mesoporous carbon nanoparticles for chemo-photothermal therapy.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  669  (131450).  [PMID:] [10.1016/j.colsurfa.2023.131450]
3. Shanshan Wang, Yan Qin, Qiuyu Wen, Quan Xia, Ruoyu Gu, Sheng Wang, GuanJun Chen, Chao Tan, Chenlin Shen, Shuai Song.  (2022)  Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration.  Drug Metabolism and Pharmacokinetics,  45  (100458).  [PMID:35569194] [10.1016/j.dmpk.2022.100458]
4. Yu Zhang, Xin Xu, Bing Yan.  (2022)  A multicolor-switchable fluorescent lanthanide MOFs triggered by anti-cancer drugs: multifunctional platform for anti-cancer drug sensing and information anticounterfeiting.  Journal of Materials Chemistry C,  10  (9): (3576-3584).  [PMID:] [10.1039/D1TC05935A]
5. Binbin Zhou, Weihui Ou, Chenghao Zhao, Junda Shen, Guobin Zhang, Xianghu Tang, Zhiqin Deng, Guangyu Zhu, Yang Yang Li, Jian Lu.  (2021)  Insertable and reusable SERS sensors for rapid on-site quality control of fish and meat products.  CHEMICAL ENGINEERING JOURNAL,  426  (130733).  [PMID:] [10.1016/j.cej.2021.130733]
6. Bo Tao, Zong-ning Yin.  (2020)  Synthesis of HA-SS-MP: A Prodrug With High Specificity for Cancer Cells.  Natural Product Communications,      [PMID:] [10.1177/1934578X20932761]
7. Yuqian Jiang, Zheng Wang, Wei Duan, Lingyan Liu, Mahan Si, Xiaoyuan Chen, Chen-Jie Fang.  (2020)  The critical size of gold nanoparticles for overcoming P-gp mediated multidrug resistance.  Nanoscale,  12  (31): (16451-16461).  [PMID:32790812] [10.1039/D0NR03226C]
8. Zhang Feng, Liu Hua, Liu Qing, Su Xingguang.  (2018)  An enzymatic ratiometric fluorescence assay for 6-mercaptopurine by using MoS2 quantum dots.  MICROCHIMICA ACTA,  185  (12): (1-8).  [PMID:30415422] [10.1007/s00604-018-3039-4]
9. Deng Hao-Hua, Huang Kai-Yuan, Zhuang Qiong-Qiong, Zhuang Quan-Quan, Peng Hua-Ping, Liu Yin-Huan, Xia Xing-Hua, Chen Wei.  (2018)  Preparation of strongly fluorescent water-soluble dithiothreitol modified gold nanoclusters coated with carboxychitosan, and their application to fluorometric determination of the immunosuppressive 6-mercaptopurine.  MICROCHIMICA ACTA,  185  (8): (1-8).  [PMID:30076470] [10.1007/s00604-018-2933-0]
10. Yang Yang, Shuang Zhou, Ruizhuo Ouyang, Yaoqin Yang, Huihong Tao, Kai Feng, Xiaoshen Zhang, Fei Xiong, Ning Guo, Tianyu Zong, Penghui Cao, Yuhao Li, Yuqing Miao.  (2016)  Improvement in the Anticancer Activity of 6-Mercaptopurine via Combination with Bismuth(III).  CHEMICAL & PHARMACEUTICAL BULLETIN,  64  (11): (1539-1545).  [PMID:27803465] [10.1248/cpb.c15-00949]
11. Lixia Zhang, Hongli Li, Guang Chu, Lan Luo, Jing Jin, Bing Zhao, Yuan Tian.  (2016)  Detection of 6-Mercaptopurine by silver nanowires-coated silicon wafer based on surface-enhanced Raman scattering spectroscopy.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  508  (309).  [PMID:] [10.1016/j.colsurfa.2016.08.069]
12. Yusheng Yuan, Yalan Wang, Shaopu Liu, Yuanfang Li, Ruilin Duan, Hui Zhang, Xiaoli Hu.  (2016)  Fluorescence quenching and spectrophotometric methods for the determination of 6-mercaptopurine based on carbon dots.  RSC Advances,  (57): (52255-52263).  [PMID:] [10.1039/C6RA07675K]
13. Liyan Shi, Kaikai Ding, Xin Sun, Ling Zhang, Tian Zeng, Yihua Yin, Hua Zheng.  (2016)  Preparation, characterization, and in vitro drug release behavior of glutathione-sensitive long-circulation micelles based on polyethylene glycol prodrug.  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,      [PMID:26764973] [10.1080/09205063.2016.1140502]
14. Han Cao, Yuhong Yang, Xin Chen, Zhengzhong Shao.  (2016)  Intelligent Janus nanoparticles for intracellular real-time monitoring of dual drug release.  Nanoscale,  (12): (6754-6760).  [PMID:26952741] [10.1039/C6NR00987E]
15. Ai Ping Li, Jing Dong Peng, MingQiong Zhou, Jin Zhang.  (2016)  Resonance light scattering determination of 6-mercaptopurine coupled with HPLC technique.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  154  (1).  [PMID:26479445] [10.1016/j.saa.2015.09.010]
16. Ke Zeng, Jin Li, Zhaoguo Zhang, Mina Yan, Yunhui Liao, Xuefei Zhang, Chunshun Zhao.  (2015)  Lipid-coated ZnO nanoparticles as lymphatic-targeted drug carriers: study on cell-specific toxicity in vitro and lymphatic targeting in vivo.  Journal of Materials Chemistry B,  (26): (5249-5260).  [PMID:32262600] [10.1039/C5TB00486A]
17. Zhengjuan Sun, Yali Liu, Yuanfang Li.  (2015)  Selective recognition of 6-mercaptopurine based on luminescent metal–organic frameworks Fe-MIL-88NH2.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  139  (296).  [PMID:25574647] [10.1016/j.saa.2014.12.009]
18. Xiao-Yu Gong, Yi-Hua Yin, Zhi-Jun Huang, Bo Lu, Pei-Hu Xu, Hua Zheng, Fu-Liang Xiong, Hai-Xing Xu, Xiong Xiong, Xing-Bao Gu.  (2012)  Preparation, characterization and in vitro release study of a glutathione-dependent polymeric prodrug Cis-3-(9H-purin-6-ylthio)-acrylic acid-graft-carboxymethyl chitosan.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  436  (240).  [PMID:22750430] [10.1016/j.ijpharm.2012.06.043]
19. Xuzhu Zhang, Fang Du, Jin Huang, Wei Lu, Shiyuan Liu, Jiahui Yu.  (2012)  Fabrication of biodegradable micelles with reduction-triggered release of 6-mercaptopurine profile based on disulfide-linked graft copolymer conjugate.  COLLOIDS AND SURFACES B-BIOINTERFACES,  100  (155).  [PMID:22766292] [10.1016/j.colsurfb.2012.04.043]
20. Hua Zheng, Yan Rao, Yihua Yin, Xiong Xiong, Peihu Xu, Bo Lu.  (2011)  Preparation, characterization, and in vitro drug release behavior of 6-mercaptopurine-carboxymethyl chitosan.  CARBOHYDRATE POLYMERS,  83  (1952).  [PMID:] [10.1016/j.carbpol.2010.10.069]
21. Bo Tao,Zongning Yin.  (2020-05-20)  Redox-Responsive Coordination Polymers of Dopamine-Modified Hyaluronic Acid with Copper and 6-Mercaptopurine for Targeted Drug Delivery and Improvement of Anticancer Activity against Cancer Cells..  Polymers,  12  ((5)):   [PMID:32423174]
22. Jian Dong,Qingfeng Chen,Chunhui Rong,Danyang Li,Yanying Rao.  (2011-07-07)  Minimally invasive surface-enhanced Raman scattering detection with depth profiles based on a surface-enhanced Raman scattering-active acupuncture needle..  Analytical chemistry,  83  ((16)): (6191-6195).  [PMID:21728307]

Solution Calculators