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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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M166349-250mg | 250mg | In stock | $48.90 | |
M166349-1g | 1g | In stock | $150.90 | |
M166349-5g | 5g | In stock | $521.90 | |
M166349-25g | 25g | In stock | $2,346.90 |
Broad-spectum β-lactam antibiotic
Synonyms | s4846 | (4R,5S,6S)-3-(((3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate | Meropenem trihydrate, European Pharmacopoeia (EP) Reference Standard | 1-Azabicycl |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Meropenem trihydrate is an ultra-broad spectrum beta-lactam antibiotic active against both Gram-positive and Gram-negative bacteria.Broad-spectrum β-lactam antibiotic. Blood-brain barrier permeable. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Meropenem trihydrate is an ultra-broad spectrum beta-lactam antibiotic active against both Gram-positive and Gram-negative bacteria. Meropenem trihydrate (MRP) belongs to the carbapenem group of compounds. It is susceptible to degradation at high temperature and humidity. It is soluble in methanol-water or acetone-water combinations. It is used as an antibacterial agent for treating meningitis and pneumonia. |
ALogP | -2.4 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;trihydrate |
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INCHI | InChI=1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1 |
InChi Key | CTUAQTBUVLKNDJ-OBZXMJSBSA-N |
Canonical SMILES | CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O.O.O.O |
Isomeric SMILES | C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)C(=O)N(C)C)C(=O)O)[C@@H](C)O.O.O.O |
WGK Germany | 3 |
Alternate CAS | 96036-03-2 |
PubChem CID | 441129 |
Molecular Weight | 437.51 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2122182 | Certificate of Analysis | Jul 11, 2024 | M166349 |
I2122184 | Certificate of Analysis | Jul 11, 2024 | M166349 |
I2122185 | Certificate of Analysis | Jul 11, 2024 | M166349 |
K2322445 | Certificate of Analysis | Jan 09, 2023 | M166349 |
K2322446 | Certificate of Analysis | Jan 09, 2023 | M166349 |
K2212287 | Certificate of Analysis | Aug 29, 2022 | M166349 |
K2212288 | Certificate of Analysis | Aug 29, 2022 | M166349 |
K2212289 | Certificate of Analysis | Aug 29, 2022 | M166349 |
K2212293 | Certificate of Analysis | Aug 29, 2022 | M166349 |
Solubility | Soluble in aqueous solution at approximately 5mg/ml |
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Sensitivity | heat sensitive |
Specific Rotation[α] | -18° (C=0.44,H2O) |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Merck Index | 5900 |
Starting at $69.90
1. Greater Kayode Oyejobi, Dongyan Xiong, Mengjuan Shi, Xiaoxu Zhang, Hang Yang, Heng Xue, Faith Ogolla, Hongping Wei. (2022) Genetic Signatures from Adaptation of Bacteria to Lytic Phage Identify Potential Agents to Aid Phage-Killing of Multidrug-Resistant Acinetobacter baumannii. JOURNAL OF BACTERIOLOGY, [PMID:35156836] [10.1128/jb.00593-21] |
1. Greater Kayode Oyejobi, Dongyan Xiong, Mengjuan Shi, Xiaoxu Zhang, Hang Yang, Heng Xue, Faith Ogolla, Hongping Wei. (2022) Genetic Signatures from Adaptation of Bacteria to Lytic Phage Identify Potential Agents to Aid Phage-Killing of Multidrug-Resistant Acinetobacter baumannii. JOURNAL OF BACTERIOLOGY, [PMID:35156836] [10.1128/jb.00593-21] |