Basic Description

Synonyms	DIM-SA \| DMS \| DMSA \| DMSA (Meso-2,3-dimercaptosuccinic acid) \| HSDB 6783 \| meso-Dimercaptosuccinic acid \| Acid, meso-Dimercaptosuccinic \| Butanedioic acid, 2,3-dimercapto-, (R,S)- \| Succimero [INN-Spanish] \| SUCCIMER [USAN] \| D00572 \| meso-2,3-Dimercap
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Lead chelating agent and ROS° scavenger. Hypotensive effect in vitro . Reduces oxidative stress and apoptosis in vivo . Orally active. Active in vivo and in vitro .
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Action Type	CHELATING AGENT
Mechanism of action	Lead chelating agent
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	DMSA (Meso-2,3-dimercaptosuccinic acid) is a potent lead chelating agent found to be a scavenger of reactive oxygen species (ROS). Murine experiments have shown that this compound also lowers blood pressure in rat arterial hypertension via a decrease in total cell calcium levels. It has also been observed that DMSA upregulates mRNA expression of macrophage-1 antigen, L-, E-, and P-selectin, as well as causing an increase in TNFα (tumor necrosis factor-α) concentrations in murine lung. Mechanistic studies suggest that DMSA is metabolized into mixed disulfides of cysteine, which are active chelating agents. A water-soluble chelating agent.

Product Properties

ALogP	0.1

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

Discover Target: F2

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

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PGR Tclin Progesterone receptor (8562 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

Discover Target: CHRM2

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

Discover Target: HTR1A

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

Discover Target: ADRA2A

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AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

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GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

Discover Target: GABRA1

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MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

Discover Target: DRD1

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ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

Discover Target: SLC6A2

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ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

Discover Target: SLC6A4

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

Discover Target: SLC6A3

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KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

Discover Target: PDE3A

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HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

Discover Target: HTR2B

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TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)

Discover Target: TBXA2R

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PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

Discover Target: PDE4A

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HRH3 Tclin Histamine H3 receptor (10389 Activities)

Discover Target: HRH3

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Homo sapiens (32628 Activities)

Explore this target

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ABCB11 Tchem Bile salt export pump (2311 Activities)

Discover Target: ABCB11

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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groL GroEL/GroES (1042 Activities)

Discover Target: groL

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S,3R)-2,3-bis(sulfanyl)butanedioic acid
INCHI	InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+
InChi Key	ACTRVOBWPAIOHC-XIXRPRMCSA-N
Canonical SMILES	C(C(C(=O)O)S)(C(=O)O)S
Isomeric SMILES	[C@@H]([C@@H](C(=O)O)S)(C(=O)O)S
WGK Germany	2
RTECS	WM7650000
PubChem CID	2724354
Molecular Weight	182.22
Beilstein	1725150
Reaxy-Rn	1725150

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
J2423554	Certificate of Analysis	Aug 29, 2024	D107254
J2423560	Certificate of Analysis	Aug 29, 2024	D107254
J2423562	Certificate of Analysis	Aug 29, 2024	D107254
D2222039	Certificate of Analysis	Mar 09, 2022	D107254
D2222042	Certificate of Analysis	Mar 09, 2022	D107254
D2222063	Certificate of Analysis	Mar 09, 2022	D107254
D2222067	Certificate of Analysis	Mar 09, 2022	D107254
D2408095	Certificate of Analysis	Mar 09, 2022	D107254

Chemical and Physical Properties

Solubility	Soluble in water, and ethanol (25 mg/ml, Colorless to Light Yellow, Clear).
Sensitivity	air sensitive
Melt Point(°C)	196-198°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	WM7650000
Reaxy-Rn	1725150

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SKU	Size	Availability	Price
D107254-1g	1g	In stock	$16.90
D107254-5g	5g	In stock	$61.90
D107254-25g	25g	In stock	$240.90
D107254-100g	100g	In stock	$865.90

meso-2,3-Dimercaptosuccinic acid - 98%, high purity , Lead chelating agent, CAS No.304-55-2, Lead chelating agent