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Methotrexate Dimethyl Ester , CAS No.34378-65-9

Item Number

M341243

Grouped product items
SKU	Size	Availability	Price	Qty
M341243-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$213.90

Basic Description

Synonyms	L-GLUTAMIC ACID, N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYL)METHYLAMINO)BENZOYL)-, 1,5-DIMETHYL ESTER \| DTXSID60955926 \| METHOTREXATE IMPURITY J [EP IMPURITY] \| Dimethyl N-(4-{[(4-amino-2-imino-2,3-dihydropteridin-6-yl)methyl](methyl)amino}benzoyl)glutamate
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Methotrexate Dimethyl Ester is the esterified form of Methotrexate which is an antineoplastic and antirheumatic agent. Studies indicate that Methotrexate Dimethyl Ester can act as a folic acid antagonist. Methotrexate competitively and irreversibly inhibits DHFR (dihydrofolate reductase) which is essential in tetrahydrofolate synthesis. In addition, the reduction in tetrahydrofolate synthesis causes a decrease in purine base synthesis which results in the inhibition of DNA, RNA, thymidylates, and proteins. Alternate studies suggest that Methotrexate Dimethyl Ester can suppress T cell activation and adhesion molecule expression through IL-1 suppression.

DHFR Tclin Dihydrofolate reductase (3072 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium tuberculosis (203094 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	dimethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
INCHI	InChI=1S/C22H26N8O5/c1-30(11-13-10-25-19-17(26-13)18(23)28-22(24)29-19)14-6-4-12(5-7-14)20(32)27-15(21(33)35-3)8-9-16(31)34-2/h4-7,10,15H,8-9,11H2,1-3H3,(H,27,32)(H4,23,24,25,28,29)/t15-/m0/s1
InChi Key	DIQFVFAFHNQUTG-HNNXBMFYSA-N
Canonical SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)OC)C(=O)OC
Isomeric SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)OC)C(=O)OC
PubChem CID	118159
Molecular Weight	482.49

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Solubility	Soluble in DMF, DMSO and Methanol
Melt Point(°C)	134-140° C

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