Discover Methoxy-X04 by Aladdin Scientific in ≥97% for only $22.90. Available - in Ligands at Aladdin Scientific. Blood-brain barrier permeable amyloid β fluorescent marker Tags: .
Basic Description
Specifications & Purity
≥97%
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
Description：
Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.1 It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease.1,2 For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging.2 Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.2
1.Lonnemann N et al.. (2022) IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer's disease mouse model.. Elife, 11 [PMID:36040311]
2.Honarpisheh P et al.. (2020) Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-ß in Tg2576 Mice.. Int J Mol Sci, 21 (5):[PMID:32138161]
3.Klunk WE et al.. (2002) Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.. J Neuropathol Exp Neurol, 61 (9):(797-805). [PMID:12230326]
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I2208232