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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M609399-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,300.90 | |
M609399-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,000.90 |
Synonyms | compound 8c;EHT 5372;compound 72 |
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Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1B |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | methyl 9-(4-chloroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate |
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INCHI | InChI=1S/C17H12ClN5OS/c1-24-15(19)17-23-12-7-6-11-13(14(12)25-17)16(21-8-20-11)22-10-4-2-9(18)3-5-10/h2-8,19H,1H3,(H,20,21,22) |
InChi Key | BGXZIBSLBRKDTP-UHFFFAOYSA-N |
Canonical SMILES | COC(=N)c1nc2c(s1)c1c(ncnc1cc2)Nc1ccc(cc1)Cl |
Isomeric SMILES | COC(=N)C1=NC2=C(S1)C3=C(C=C2)N=CN=C3NC4=CC=C(C=C4)Cl |
PubChem CID | 71529770 |
BindingDB Ligand | 50434338 |
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PubChem CID | 71529770 |
ChEMBL Ligand | CHEMBL2386762 |
Enter Lot Number to search for COA:
1. Ryoo SR, Jeong HK, Radnaabazar C, Yoo JJ, Cho HJ, Lee HW, Kim IS, Cheon YH, Ahn YS, Chung SH et al.. (2007) DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.. J Biol Chem, 282 (48): (34850-7). [PMID:17906291] |
2. Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H et al.. (2007) The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.. Hum Mol Genet, 16 (1): (15-23). [PMID:17135279] |
3. Ferrer I, Barrachina M, Puig B, Martínez de Lagrán M, Martí E, Avila J, Dierssen M. (2005) Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models.. Neurobiol Dis, 20 (2): (392-400). [PMID:16242644] |
4. Park J, Song WJ, Chung KC. (2009) Function and regulation of Dyrk1A: towards understanding Down syndrome.. Cell Mol Life Sci, 66 (20): (3235-40). [PMID:19685005] |
5. Foucourt A, Hédou D, Dubouilh-Benard C, Girard A, Taverne T, Casagrande AS, Désiré L, Leblond B, Besson T. (2014) Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II.. Molecules, 19 (10): (15411-39). [PMID:25264830] |
6. Coutadeur S, Benyamine H, Delalonde L, de Oliveira C, Leblond B, Foucourt A, Besson T, Casagrande AS, Taverne T, Girard A et al.. (2015) A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.. J Neurochem, 133 (3): (440-51). [PMID:25556849] |