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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M275784-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $692.90 |
Selective, active site directed, irreversible cPLA 2 and iPLA 2 inhibitor. Potent FAAH inhibitor.
Synonyms | (5Z,8Z,11Z,14Z)-1-[Fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Selective, active site directed, irreversible cPLA 2 and iPLA 2 inhibitor. Potent FAAH inhibitor (IC 50 = 2.5 nM). I nhibits A23187 induced arachidonic acid release from platelets (IC 50 = 600 nM). |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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IUPAC Name | (5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene |
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INCHI | InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16- |
InChi Key | KWKZCGMJGHHOKJ-ZKWNWVNESA-N |
Canonical SMILES | CCCCCC=CCC=CCC=CCC=CCCCCP(=O)(OC)F |
Isomeric SMILES | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(=O)(OC)F |
PubChem CID | 10429254 |
Molecular Weight | 370.5 |
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Solubility | Soluble in DMSO to 100 mM and in ethanol to 100 mM |
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1. Mangini M et al.. (2022) Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A2.. Front Cell Dev Biol, 10 (966950). [PMID:36105351] |