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Methyl-p-toluenesulfonate - 98.0%, high purity , CAS No.80-48-8

1 Citations
  • AR
    •
  • ≥98%
Item Number
M105177
Grouped product items
SKUSizeAvailabilityPrice Qty
M105177-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$10.90
M105177-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$31.90
M105177-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$76.90
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Basic Description

SynonymsMethyl p-toluenesulfonate | 80-48-8 | Methyl 4-methylbenzenesulfonate | Methyl tosylate | Methyl p-tosylate | Methyl toluene-4-sulfonate | Methyl-p-toluenesulfonate | Methyl toluenesulfonate | Benzenesulfonic acid, 4-methyl-, methyl ester | Methyl toluene-4-sulphonate | p-To
Specifications & PurityAR, ≥98%
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
GradeAR
Product Description

Methyl p-toluenesulfonate is sulfonate ester present as potentially genotoxic impurity in drug substances. Kinetics of reactions of methyl p-toluenesulfonate with N,N-dimethylaniline has been investigated. It participates in selective 1-substitution reaction of tetrazole.

Associated Targets(Human)

PHPT1 Tbio 14 kDa phosphohistidine phosphatase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PHPT1 Tbio 14 kDa phosphohistidine phosphatase (30 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name methyl 4-methylbenzenesulfonate
INCHI InChI=1S/C8H10O3S/c1-7-3-5-8(6-4-7)12(9,10)11-2/h3-6H,1-2H3
InChi Key VUQUOGPMUUJORT-UHFFFAOYSA-N
Canonical SMILES CC1=CC=C(C=C1)S(=O)(=O)OC
Isomeric SMILES CC1=CC=C(C=C1)S(=O)(=O)OC
WGK Germany 3
RTECS XT7000000
PubChem CID 6645
UN Number 3261
Molecular Weight 186.23
Beilstein 609209
Reaxy-Rn 609209

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot NumberCertificate TypeDateItem
D2311624Certificate of AnalysisFeb 17, 2023 M105177
D2311662Certificate of AnalysisFeb 17, 2023 M105177
D2311680Certificate of AnalysisFeb 17, 2023 M105177
I2202379Certificate of AnalysisJul 16, 2022 M105177
I2202380Certificate of AnalysisJul 16, 2022 M105177
I2202381Certificate of AnalysisJul 16, 2022 M105177
I2202445Certificate of AnalysisJul 16, 2022 M105177
C1827109Certificate of AnalysisJan 20, 2022 M105177

Chemical and Physical Properties

SolubilitySoluble in ether, alcohol, benzene and chloroform. Slightly soluble in petroleum ether. Insoluble in water.
SensitivityMoisture sensitive
Freezing Point(°C)25 °C
Refractive Index1.5162-1.5182
Flash Point(°F)305°F
Flash Point(°C)152 °C
Boil Point(°C)292°C
Melt Point(°C)24-30°C

Safety and Hazards(GHS)

Pictogram(s) GHS05,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H314:Causes severe skin burns and eye damage

H302:Harmful if swallowed

H318:Causes serious eye damage

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P363:Wash contaminated clothing before reuse.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P317:Get emergency medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes.

P316:Get emergency medical help immediately.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS XT7000000
Reaxy-Rn 609209

Related Documents

 SDS

 Specification Sheet

Citations of This Product

1. Luqiao Wen,Shouzhen Huang,Weiang Du,Caili Zhu,Huan Xu.  (2020-01-17)  Effects of the molecular weight and molar ratio of poly(2-ethyl-2-oxazoline)-based lipid on the pH sensitivity, stability, and antitumor efficacy of liposomes..  Drug development and industrial pharmacy,  46  ((2)): (283-295).  [PMID:31944130]

References

1. Tian Guo,Yuanyuan Shi,Li Zheng,Feng Feng,Feng Zheng,Wenyuan Liu.  (2014-07-06)  Rapid and simultaneous determination of sulfonate ester genotoxic impurities in drug substance by liquid chromatography coupled to tandem mass spectrometry: comparison of different ionization modes..  Journal of chromatography. A,  1355  (73-79).  [PMID:24997109]
2. Bryn D Monnery,Michael Wright,Rachel Cavill,Richard Hoogenboom,Sunil Shaunak,Joachim H G Steinke,Maya Thanou.  (2017-02-25)  Cytotoxicity of polycations: Relationship of molecular weight and the hydrolytic theory of the mechanism of toxicity..  International journal of pharmaceutics,  521  ((1-2)): (249-258).  [PMID:28232268]
3. Lucca Trachsel,Matteo Romio,Benjamin Grob,Marcy Zenobi-Wong,Nicholas D Spencer,Shivaprakash N Ramakrishna,Edmondo M Benetti.  (2020-07-07)  Functional Nanoassemblies of Cyclic Polymers Show Amplified Responsiveness and Enhanced Protein-Binding Ability..  ACS nano,  14  ((8)): (10054-10067).  [PMID:32628438]
4. Polen Kocak,Umut Can Oz,Zeynep Busra Bolat,Umut Ugur Ozkose,Sevgi Gulyuz,Mehmet Atilla Tasdelen,Ozgur Yilmaz,Asuman Bozkir,Fikrettin Sahin,Dilek Telci.  (2020-11-17)  The Utilization of Poly(2-ethyl-2-oxazoline)-b-Poly(ε-caprolactone) Ellipsoidal Particles for Intracellular BIKDDA Delivery to Prostate Cancer..  Macromolecular bioscience,  21  ((2)): (e2000287-e2000287).  [PMID:33191572]
5. Joachim F R Van Guyse,Debaditya Bera,Richard Hoogenboom.  (2021-02-04)  Adamantane Functionalized Poly(2-oxazoline)s with Broadly Tunable LCST-Behavior by Molecular Recognition..  Polymers,  13  ((3)):   [PMID:33530443]
6. Luqiao Wen,Shouzhen Huang,Weiang Du,Caili Zhu,Huan Xu.  (2020-01-17)  Effects of the molecular weight and molar ratio of poly(2-ethyl-2-oxazoline)-based lipid on the pH sensitivity, stability, and antitumor efficacy of liposomes..  Drug development and industrial pharmacy,  46  ((2)): (283-295).  [PMID:31944130]

Solution Calculators

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