Grouped product items

SKU

Size

Availability

Price

Qty

M425109-1ml

1ml

Available within 4-8 weeks(?)

$54.90

Basic Description

Synonyms	methylene blue\|61-73-4\|Basic blue 9\|Methylthioninium chloride\|Solvent blue 8\|Swiss Blue\|Chromosmon\|Methylene Blue anhydrous\|Methylene Blue N\|Methylene Blue BB\|Methylenium ceruleum\|C.I. Basic Blue 9\|Urolene blue\|3,7-Bis(dimethylamino)phenothiazin-5-ium chl
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Biological stain and redox indicator. Inhibits tau filament formation (IC50= 1.9μM). Also inhibits soluble guanylyl cyclase.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets

DLD Tbio Dihydrolipoyl dehydrogenase, mitochondrial 0 Activities

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POLB Tchem DNA polymerase beta 0 Activities

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EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

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DLX6 Tbio Homeobox protein DLX-6 0 Activities

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MSTN Tclin Growth/differentiation factor 8 0 Activities

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GMNN Tbio Geminin 0 Activities

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PTH1R Tclin Parathyroid hormone/parathyroid hormone-related peptide receptor 0 Activities

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RAD52 Tchem DNA repair protein RAD52 homolog 1 Activities

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POLH Tchem DNA polymerase eta 0 Activities

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PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 0 Activities

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FTL Tbio Ferritin light chain 0 Activities

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FGB Tbio Fibrinogen beta chain 0 Activities

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KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

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FEN1 Tchem Flap endonuclease 1 0 Activities

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TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

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SMN1 Tchem Survival motor neuron protein 0 Activities

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SNCA Tchem Alpha-synuclein 0 Activities

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SMAD3 Tchem Mothers against decapentaplegic homolog 3 0 Activities

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TSHR Tclin Thyrotropin receptor 0 Activities

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PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 Activities

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POLI Tchem DNA polymerase iota 0 Activities

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RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities

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PKM Tchem Pyruvate kinase PKM 0 Activities

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LHCGR Tclin Lutropin-choriogonadotropic hormone receptor 0 Activities

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MBNL1 Tbio Muscleblind-like protein 1 0 Activities

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CASP6 Tchem Caspase-6 0 Activities

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BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

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ALB Tchem Serum albumin 0 Activities

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MAOA Tclin Amine oxidase [flavin-containing] A 1 Activities

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APP Tclin Amyloid-beta A4 protein 1 Activities

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THRB Tclin Thyroid hormone receptor beta 0 Activities

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MAPT Tclin Microtubule-associated protein tau 2 Activities

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ATM Tchem Serine-protein kinase ATM 0 Activities

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APAF1 Tchem Apoptotic protease-activating factor 1 0 Activities

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GSR Tclin Glutathione reductase, mitochondrial 0 Activities

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IMPA1 Tclin Inositol monophosphatase 1 0 Activities

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GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic 0 Activities

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PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

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NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

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NPSR1 Tchem Neuropeptide S receptor 0 Activities

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KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

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KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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Names and Identifiers

IUPAC Name	[7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride
INCHI	InChI=1S/C16H18N3S.ClH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;/h5-10H,1-4H3;1H/q+1;/p-1
InChi Key	CXKWCBBOMKCUKX-UHFFFAOYSA-M
Canonical SMILES	CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]
Isomeric SMILES	CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]
RTECS	SO5600000
PubChem CID	6099
Molecular Weight	319.85
Beilstein	27395
Reaxy-Rn	3599847

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Flash Point(°C)	14°C
Melt Point(°C)	190°C

Safety and Hazards(GHS)

Pictogram(s)	GHS05, GHS07
Signal	Danger
Hazard Statements	H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed H318:Causes serious eye damage
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help.
RTECS	SO5600000
Reaxy-Rn	3599847

References

1. Chuanjie Liu. (2022) Facile Access to Gleditsia microphylla Galactomannan Hydrogel with Rapid Self-Repair Capacity and Multicyclic Water-Retaining Performance of Sandy Soil. Polymers, 5430 (14): (1-14). [PMID:]

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Methylene blue - 10mM in DMSO, high purity , CAS No.61-73-4