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Home Cardiovascular Heart Autophagy Methyllycaconitine citrate (MLA) - ≥98%, high purity , CAS No.21019-30-7, Antagonist of nicotinic acetylcholine receptor α10 subunit;Antagonist of nicotinic acetylcholine receptor α7 subunit;Antagonist of nicotinic acetylcholine receptor α9 subunit
Methyllycaconitine citrate (MLA) - ≥98%, high purity , CAS No.21019-30-7, Antagonist of nicotinic acetylcholine receptor α10 subunit;Antagonist of nicotinic acetylcholine receptor α7 subunit;Antagonist of nicotinic acetylcholine receptor α9 subunit
α7 Nicotinic receptor antagonist. 1 ml water soluble pack.
Basic Description Synonyms [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diolcitrate Specifications & Purity ≥98% Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of nicotinic acetylcholine receptor α10 subunit;Antagonist of nicotinic acetylcholine receptor α7 subunit;Antagonist of nicotinic acetylcholine receptor α9 subunit Product Description Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Names and Identifiers IUPAC Name [(1S,2R,3R,4S,5R,6S,8R,9S,10S,13S,16S,17R,18S)-11-ethyl-8,9-dihydroxy-4,6,16,18-tetramethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-13-yl]methyl 2-[(3S)-3-methyl-2,5-dioxopyrrolidin-1-yl]benzoate INCHI InChI=1S/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33-,34-,35+,36-,37+/m0/s1 InChi Key XLTANAWLDBYGFU-VTLKBQQISA-N Canonical SMILES CCN1CC2(CCC(C34C2C(C(C31)(C5(CC(C6CC4C5C6OC)OC)O)O)OC)OC)COC(=O)C7=CC=CC=C7N8C(=O)CC(C8=O)C Isomeric SMILES CCN1C[C@@]2(CC[C@@H]([C@@]34[C@@H]2[C@@H]([C@@]([C@H]31)([C@]5(C[C@@H]([C@H]6C[C@@H]4[C@@H]5[C@H]6OC)OC)O)O)OC)OC)COC(=O)C7=CC=CC=C7N8C(=O)C[C@@H](C8=O)C PubChem CID 5288811 MeSH Entry Terms methyllycaconitine;methyllycaconitine hydrochloride;methyllycaconitine hydroiodide Molecular Weight 874.92
Chemical and Physical Properties Solubility Soluble in 1 ml water to give specified mM/ml concentration
References 1. Wei P et al.. (2022) α7 Nicotinic Acetylcholine Receptor May Be a Pharmacological Target for Perioperative Neurocognitive Disorders.. Front Pharmacol, 13 (907713). [PMID:35721159 ]
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