Grouped product items

SKU

Size

Availability

Price

Qty

M335082-10mg

10mg

Available within 8-12 weeks(?)

$84.90

M335082-25mg

25mg

Available within 8-12 weeks(?)

$150.90

M335082-50mg

50mg

Available within 8-12 weeks(?)

$249.90

M335082-100mg

100mg

Available within 8-12 weeks(?)

$376.90

Basic Description

Synonyms	BRN 0223622 \| NSC 7364 \| 2aov \| GTPL7412 \| Metoprine [USAN] \| AKOS015994567 \| U 197 \| C11H10Cl2N4 \| METOPRINE \| Neuro_000005 \| MLS002701892 \| SK 5265 \| NSC7364 \| NSC-7364 \| 5-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2,4-diamine(Metoprine) \| 2,4-Diamino-5
Specifications & Purity	Moligand™, ≥97%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT.

Associated Targets(Human)

DHFR Tclin Dihydrofolate reductase (3072 Activities)

Discover Target: DHFR

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PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

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SLC2A1 Tchem Glucose transporter (14755 Activities)

Discover Target: SLC2A1

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HNMT Tchem Histamine N-methyltransferase (15 Activities)

Discover Target: HNMT

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

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A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DLD-1 (17511 Activities)

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DMS-273 (14108 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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SNB-78 (14240 Activities)

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TK-10 (45540 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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XF498 (12972 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HEK293 (82097 Activities)

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Associated Targets(non-human)

Escherichia coli (133304 Activities)

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Plasmodium falciparum (966862 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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CCRF S-180 (1031 Activities)

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L1210 (27553 Activities)

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W256 (236 Activities)

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ht1 Hexose transporter 1 (14071 Activities)

Discover Target: ht1

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5-(3,4-dichlorophenyl)-6-methylpyrimidine-2,4-diamine
INCHI	InChI=1S/C11H10Cl2N4/c1-5-9(10(14)17-11(15)16-5)6-2-3-7(12)8(13)4-6/h2-4H,1H3,(H4,14,15,16,17)
InChi Key	VQJHOPSWBGJHQS-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=NC(=N1)N)N)C2=CC(=C(C=C2)Cl)Cl
Isomeric SMILES	CC1=C(C(=NC(=N1)N)N)C2=CC(=C(C=C2)Cl)Cl
RTECS	UV8180000
Alternate CAS	7761-45-7
PubChem CID	24466
NSC Number	7364
MeSH Entry Terms	2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine;BW 1970;BW 50,197;DDMP;methodichlorophen;methodichlorophen hydrochloride;metoprine
Molecular Weight	269.13

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
J2421808	Certificate of Analysis	Sep 25, 2024	M335082
J2421809	Certificate of Analysis	Sep 25, 2024	M335082
J2421810	Certificate of Analysis	Sep 25, 2024	M335082
J2421811	Certificate of Analysis	Sep 25, 2024	M335082
J2421812	Certificate of Analysis	Sep 25, 2024	M335082
J2421813	Certificate of Analysis	Sep 25, 2024	M335082
J2421814	Certificate of Analysis	Sep 25, 2024	M335082
J2421815	Certificate of Analysis	Sep 25, 2024	M335082

Chemical and Physical Properties

Solubility	DMSO: 4 mg/mL (14.86 mM)

Safety and Hazards(GHS)

RTECS	UV8180000

References

1. Malmberg-Aiello P, Ipponi A, Bartolini A, Schunack W. (2000) Antiamnesic effect of metoprine and of selective histamine H(1) receptor agonists in a modified mouse passive avoidance test.. Neurosci Lett, 288 (1): (1-4). [PMID:10869801] [10.1021/op500134e]
2. Lecklin A, Tuomisto L, MacDonald E. (1995) Metoprine, an inhibitor of histamine N-methyltransferase but not catechol-O-methyltransferase, suppresses feeding in sated and in food deprived rats.. Methods Find Exp Clin Pharmacol, 17 (1): (47-52). [PMID:7542717] [10.1021/op500134e]

Solution Calculators

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Metoprine - ≥97%, high purity , CAS No.7761-45-7

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
M335082-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$84.90
M335082-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
M335082-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$249.90
M335082-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$376.90