Basic Description

Synonyms	MG-262 \| PS-III \| 179324-22-2 \| MG262 \| Z-Leu-Leu-Leu-B(OH)2 \| CHEMBL114388 \| 549V4DP94W \| boro-LLL \| ((5S,8S,11R)-5,8-diisobutyl-13-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-11-yl)boronic acid \| UNII-549V4DP94W \| [(1R)-1-[[(2S)-2-[[(2S)-2-(benzyloxycarbonyl
Biochemical and Physiological Mechanisms	MG-262 is a reversible proteasome inhibitor with diverse biological activities.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	MG-262 is a reversible proteasome inhibitor with diverse biological activities . Form:Solid

Associated Targets(Human)

PSMB5 Tclin Proteasome subunit beta type-5 (1 Activities)

Discover Target: PSMB5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CTSB Tchem Cathepsin B (1 Activities)

Discover Target: CTSB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CTSB Tchem Cathepsin B (3822 Activities)

Discover Target: CTSB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTSS Tchem Cathepsin S (3285 Activities)

Discover Target: CTSS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPMI-8226 (44974 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PSMB2 Tclin Proteasome Macropain subunit (1025 Activities)

Discover Target: PSMB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PSMB5 Tclin Proteasome Macropain subunit MB1 (2451 Activities)

Discover Target: PSMB5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

PRE7 Proteasome component C5 (37 Activities)

Discover Target: PRE7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	[(1R)-3-methyl-1-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]butyl]boronic acid
INCHI	InChI=1S/C25H42BN3O6/c1-16(2)12-20(24(31)29-22(26(33)34)14-18(5)6)27-23(30)21(13-17(3)4)28-25(32)35-15-19-10-8-7-9-11-19/h7-11,16-18,20-22,33-34H,12-15H2,1-6H3,(H,27,30)(H,28,32)(H,29,31)/t20-,21-,22-/m0/s1
InChi Key	MWKOOGAFELWOCD-FKBYEOEOSA-N
Canonical SMILES	B(C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)(O)O
Isomeric SMILES	B([C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1)(O)O
PubChem CID	490002
Molecular Weight	519.45

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Melt Point(°C)	162-163°

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MG-262 , CAS No.179324-22-2