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E3 ubiquitin ligase components
MG-277 , CAS No.M611853, cereblon

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MG-277 , CAS No.M611853, cereblon

Moligand™

PubChem CID: 139600332

Item Number

M611853

Grouped product items
SKU	Size	Availability	Price	Qty
M611853-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M611853-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

cereblon

Basic Description

Synonyms	MG277
Specifications & Purity	Moligand™
Grade	Moligand™
Mechanism of action	cereblon

Associated Targets

GSPT1 Tbio Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 Activities

Discover Target: GSPT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CRBN Tclin Protein cereblon 13 Activities

Discover Target: CRBN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MDM2 Tchem E3 ubiquitin-protein ligase Mdm2 1 Activities

Discover Target: MDM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TP53 Tchem Cellular tumor antigen p53 0 Activities

Discover Target: TP53

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C41H42Cl2FN5O5/c42-24-14-15-28-30(21-24)46-39(54)41(28)33(26-12-8-13-29(43)34(26)44)35(48-40(41)18-4-2-5-19-40)37(52)45-20-6-1-3-9-23-10-7-11-25-27(23)22-49(38(25)53)31-16-17-32(50)47-36(31)51/h7-8,10-15,21,31,33,35,48H,1-6,9,16-20,22H2,(H,45,52)(H,46,54)(H,47,50,51)/t31?,33-,35+,41+/m0/s1
InChi Key	BANRYGZZIMCKNA-OYGJEQPESA-N
Canonical SMILES	C1CCC2(CC1)[C@@]1([C@H]([C@@H](N2)C(=O)NCCCCCc2c3CN(C(=O)c3ccc2)C2CCC(=O)NC2=O)c2c(c(ccc2)Cl)F)c2c(cc(cc2)Cl)NC1=O
Isomeric SMILES	C1CCC2(CC1)[C@@]3([C@H]([C@@H](N2)C(=O)NCCCCCC4=C5CN(C(=O)C5=CC=C4)C6CCC(=O)NC6=O)C7=C(C(=CC=C7)Cl)F)C8=C(C=C(C=C8)Cl)NC3=O
PubChem CID	139600332

Database links

PubChem CID	139600332
ChEMBL Ligand	CHEMBL4449512
BindingDB Ligand	50505628

Certificates

Certificate of Analysis(COA)

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References

1. Yang J, Li Y, Aguilar A, Liu Z, Yang CY, Wang S. (2019) Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders.. J Med Chem, 62 (21): (9471-9487). [PMID:31560543]

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