MG149 , CAS No.M611852, Inhibitor of lysine acetyltransferase 5;Inhibitor of lysine acetyltransferase 8

Item Number
M611852
Grouped product items
SKUSizeAvailabilityPrice Qty
M611852-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,300.90
M611852-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

SynonymsMG 149;MG-149
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of lysine acetyltransferase 5;Inhibitor of lysine acetyltransferase 8

Associated Targets(Human)

KAT8 Tchem Histone acetyltransferase KAT8 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KAT5 Tchem Histone acetyltransferase KAT5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EP300 Tchem Histone acetyltransferase p300 (1259 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KAT2B Tchem Histone acetyltransferase PCAF (884 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KAT5 Tchem Histone acetyltransferase KAT5 (85 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KAT8 Tchem Histone acetyltransferase KAT8 (178 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

LOX1.5 Probable linoleate 9S-lipoxygenase 5 (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-[2-(4-heptylphenyl)ethyl]-6-hydroxybenzoic acid
INCHI InChI=1S/C22H28O3/c1-2-3-4-5-6-8-17-11-13-18(14-12-17)15-16-19-9-7-10-20(23)21(19)22(24)25/h7,9-14,23H,2-6,8,15-16H2,1H3,(H,24,25)
InChi Key WBHQYBZRTAEHRR-UHFFFAOYSA-N
Canonical SMILES CCCCCCCc1ccc(cc1)CCc1cccc(c1C(=O)O)O
Isomeric SMILES CCCCCCCC1=CC=C(C=C1)CCC2=C(C(=CC=C2)O)C(=O)O
PubChem CID 49864204

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Ghizzoni M, Wu J, Gao T, Haisma HJ, Dekker FJ, George Zheng Y.  (2012)  6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site..  Eur J Med Chem,  47  (1): (337-44).  [PMID:22100137]
2. Legartová S, Stixová L, Strnad H, Kozubek S, Martinet N, Dekker FJ, Franek M, Bártová E.  (2013)  Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors..  Epigenomics,  (4): (379-96).  [PMID:23895652]
3. Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N et al..  (2017)  Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors..  Nat Commun,  (1): (1527).  [PMID:29142305]

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