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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M654562-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $495.90 |
Specifications & Purity | 10mM in DMSO |
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Biochemical and Physiological Mechanisms | mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator ( IC 50 of 9 nM) with excellent brain permeability. |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator ( IC 50 of 9 nM) with excellent brain permeability In Vivo In vivo, mGluR2 antagonist 1 (Compound 25) reverses the effect of mGluR2 agonist LY379268 in amphetamine-induced hyperlocomotion and shows good efficacy in the mouse delayed non-match to position assay at 10 mg/kg. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:mGluR2 9 nM (IC 50 ) |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Canonical SMILES | C1CC(=O)N(C1=O)CC2=CC3=C(C=C2)C(=CC(=N3)C(=O)N)C4=CC=C(C=C4)F |
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Molecular Weight | 377.37 |
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