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MI 14 - ≥98%(HPLC), high purity , CAS No.1715934-43-2
Potent and selective PI 4-kinase IIIβ inhibitor
Basic Description Synonyms N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent and selective PI 4-K IIIβinhibitor (IC50= 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβover PI 4-K IIIαand PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays Storage Temp Store at 2-8°C Shipped In Wet ice
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name N-[2-[[6-chloro-3-[3-(dimethylsulfamoyl)phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide INCHI InChI=1S/C19H23ClN6O3S/c1-12-18(14-6-5-7-15(10-14)30(28,29)25(3)4)26-19(23-12)16(11-17(20)24-26)22-9-8-21-13(2)27/h5-7,10-11,22H,8-9H2,1-4H3,(H,21,27) InChi Key PSTAJIONBVMKLA-UHFFFAOYSA-N Canonical SMILES CC1=C(N2C(=N1)C(=CC(=N2)Cl)NCCNC(=O)C)C3=CC(=CC=C3)S(=O)(=O)N(C)C Isomeric SMILES CC1=C(N2C(=N1)C(=CC(=N2)Cl)NCCNC(=O)C)C3=CC(=CC=C3)S(=O)(=O)N(C)C PubChem CID 91758319 Molecular Weight 450.94
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 9.02, Max Conc. mM: 20
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