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MI-2 - ≥98%, high purity , CAS No.1271738-62-5

≥98%

CAS#: 1271738-62-5
Formula: C₁₈H₂₅N₅S₂
Molecular Weight: 375.55
PubChem CID: 54765302

Item Number

M125261

Grouped product items
SKU	Size	Availability	Price
M125261-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$117.90
M125261-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$531.90
M125261-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$880.90

Menin-MLL\xa0interaction inhibitor that blocks cell proliferation and induces apoptosis.

Basic Description

Synonyms	1271738-62-5 \| MI-2 \| 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-propylthieno[2,3-d]pyrimidine \| 4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine \| Menin-MLL Inhibitor 2 \| Menin-MLL inhibitor MI-2 \| MI 2 (Menin-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	MI-2 is Menin-MLL inhibitor, inhibitors of the menin-MLL fusion protein interaction that specifically bind menin with nanomolar affinities.Menin-MLL (Mixed linage leukemia) protein interaction inhibitor (IC 50 = 0.45\xa0μM).\xa0\xa0Selectively inhibits pr
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.

Associated Targets(Human)

MEN1 Tchem Menin (3 Activities)

Discover Target: MEN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HL-60 (67320 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MV4-11 (7307 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin (447 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MOLM-13 (2241 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine
INCHI	InChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3
InChi Key	SRQYLNYQAPCPIR-UHFFFAOYSA-N
Canonical SMILES	CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C
Isomeric SMILES	CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C
PubChem CID	54765302
Molecular Weight	375.55

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2 results found

Lot Number	Certificate Type	Date	Item
L2325078	Certificate of Analysis	Jan 02, 2024	M125261
E1709073	Certificate of Analysis	Dec 09, 2022	M125261

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MI-2 - ≥98%, high purity , CAS No.1271738-62-5

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

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