Mibampator - 99%, high purity , Glutamate receptor ionotropic AMPA positive allosteric modulator, CAS No.375345-95-2, Glutamate receptor ionotropic AMPA positive allosteric modulator

  • ≥99%
Item Number
M649177
Grouped product items
SKUSizeAvailabilityPrice Qty
M649177-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$39.90
M649177-10mg
10mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$64.90
M649177-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$129.90
M649177-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$209.90

Basic Description

Synonyms(R)-N-(2-(4'-(2-(Methylsulfonamido)ethyl)-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide | LY451395 | 2-Propanesulfonamide, N-[(2R)-2-[4'-[2-[(methylsulfonyl)amino]ethyl][1,1'-biphenyl]-4-yl]propyl]-
Specifications & Purity≥99%
Biochemical and Physiological MechanismsMibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Action TypePOSITIVE ALLOSTERIC MODULATOR
Mechanism of actionGlutamate receptor ionotropic AMPA positive allosteric modulator

Product Properties

ALogP3.4

Associated Targets(Human)

GRIA4 Tclin Glutamate receptor 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Caco-2 (12174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria4 Glutamate receptor ionotropic, AMPA 4 (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-[(2R)-2-[4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide
INCHI InChI=1S/C21H30N2O4S2/c1-16(2)29(26,27)23-15-17(3)19-9-11-21(12-10-19)20-7-5-18(6-8-20)13-14-22-28(4,24)25/h5-12,16-17,22-23H,13-15H2,1-4H3/t17-/m0/s1
InChi Key ULRDYYKSPCRXAJ-KRWDZBQOSA-N
Canonical SMILES CC(C)S(=O)(=O)NCC(C)C1=CC=C(C=C1)C2=CC=C(C=C2)CCNS(=O)(=O)C
Isomeric SMILES C[C@@H](CNS(=O)(=O)C(C)C)C1=CC=C(C=C1)C2=CC=C(C=C2)CCNS(=O)(=O)C
Alternate CAS 375345-95-2
PubChem CID 9889366
MeSH Entry Terms LY 451395;LY-451395;LY451395;N-((2-(4'-(2-(methylsulfonyl)amino)ethyl)(1,1'-biphenyl)-4-yl)propyl)-2-propanesulfonamide
Molecular Weight 438.60

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
H2416587Certificate of AnalysisMay 06, 2024 M649177
H2416588Certificate of AnalysisMay 06, 2024 M649177
H2416589Certificate of AnalysisMay 06, 2024 M649177
H2416590Certificate of AnalysisMay 06, 2024 M649177

Chemical and Physical Properties

SolubilityDMSO : ≥ 25 mg/mL (57.00 mM)

Related Documents

Solution Calculators