Mifepristone is a progesterone (PR) and glucocorticoid receptor (GR) antagonist which has demonstrated the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflamm
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
AGONIST, ANTAGONIST
Mechanism of action
Progesterone receptor antagonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. A progesterone and glucocorticoid antagonist, suppresses VEGF production.
1.Qi-qiang Zhang, Xue-mei Di, Xiang Cao, Yonghong Nie, Wen Shuai, Jun Li, Hai Zhang. (2023) Analysis of pharmacodynamic components, targets and synergistic action mechanism of Fuyuan Shenghua granule for the treatment of medical-induced incomplete abortion based on network pharmacology. JOURNAL OF ETHNOPHARMACOLOGY, (117118). [PMID:37659757][10.1016/j.jep.2023.117118]
2.Sheng Hu, Pei Shen, Bin Chen, Shao-Wen Tian, Yong You. (2022) Apelin-13 reduces lipopolysaccharide-induced neuroinflammation and cognitive impairment via promoting glucocorticoid receptor expression and nuclear translocation. NEUROSCIENCE LETTERS, 788 (136850). [PMID:36038029][10.1016/j.neulet.2022.136850]
3.Mengru Bai, Mingyang Chen, Qingquan Zeng, Shuanghui Lu, Ping Li, Zhiyuan Ma, Nengming Lin, Caihong Zheng, Hui Zhou, Su Zeng, Dongli Sun, Huidi Jiang. (2022) Up-regulation of hepatic CD36 by increased corticosterone/cortisol levels via GR leads to lipid accumulation in liver and hypertriglyceridaemia during pregnancy. BRITISH JOURNAL OF PHARMACOLOGY, 179 (17):(4440-4456). [PMID:35491243][10.1111/bph.15863]
4.Yao Xin-peng, Jiao Ting-ying, Jiang Yi-ming, Fan Shi-cheng, Zhao Ying-yuan, Yang Xiao, Gao Yue, Li Fei, Zhou Yan-ying, Chen Pan-pan, Huang Min, Bi Hui-chang. (2021) PXR mediates mifepristone-induced hepatomegaly in mice. ACTA PHARMACOLOGICA SINICA, 43 (1):(146-156). [PMID:33782543][10.1038/s41401-021-00633-4]
5.Chang Shu, Teng-Fei Li, Duo Li, Zhong-Qiu Li, Xing-Hua Xia. (2021) Barcode signal amplifying strategy for sensitive and accurate protein detection on LC-MS/MS. ANALYST, 146 (5):(1725-1733). [PMID:33459316][10.1039/D0AN01948H]
References
1.Zhang B et al.. (2020) Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling.. J Neuroinflammation, 17 (318). [PMID:33100225]
2.Shannon S et al.. (2015) Dexamethasone-Mediated Activation of Fibronectin Matrix Assembly Reduces Dispersal of Primary Human Glioblastoma Cells.. PLoS One, 10 (8):(e0135951). [PMID:26284619]
3.Nair M et al.. (2018) Dexamethasone-Mediated Upregulation of Calreticulin Inhibits Primary Human Glioblastoma Dispersal Ex Vivo.. Int J Mol Sci, 19 (2):[PMID:29443896]
4.Xiao R et al.. (2016) Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.. Cancer Immunol Res, 4 (6):(488-497). [PMID:27045020]
5.Wang C et al.. (2017) Experimental research on the relationship between the stiffness and the expressions of fibronectin proteins and adaptor proteins of rat trabecular meshwork cells.. BMC Ophthalmol, 17 (268). [PMID:29284449]
6.Karami Kheirabad M et al.. (2015) Expression of Melanocortin-4 Receptor mRNA in Male Rat Hypothalamus During Chronic Stress.. Int J Mol Cell Med, 4 (3):(182-7). [PMID:26629487]
7.Qi-qiang Zhang, Xue-mei Di, Xiang Cao, Yonghong Nie, Wen Shuai, Jun Li, Hai Zhang. (2023) Analysis of pharmacodynamic components, targets and synergistic action mechanism of Fuyuan Shenghua granule for the treatment of medical-induced incomplete abortion based on network pharmacology. JOURNAL OF ETHNOPHARMACOLOGY, (117118). [PMID:37659757][10.1016/j.jep.2023.117118]
8.Sheng Hu, Pei Shen, Bin Chen, Shao-Wen Tian, Yong You. (2022) Apelin-13 reduces lipopolysaccharide-induced neuroinflammation and cognitive impairment via promoting glucocorticoid receptor expression and nuclear translocation. NEUROSCIENCE LETTERS, 788 (136850). [PMID:36038029][10.1016/j.neulet.2022.136850]
9.Mengru Bai, Mingyang Chen, Qingquan Zeng, Shuanghui Lu, Ping Li, Zhiyuan Ma, Nengming Lin, Caihong Zheng, Hui Zhou, Su Zeng, Dongli Sun, Huidi Jiang. (2022) Up-regulation of hepatic CD36 by increased corticosterone/cortisol levels via GR leads to lipid accumulation in liver and hypertriglyceridaemia during pregnancy. BRITISH JOURNAL OF PHARMACOLOGY, 179 (17):(4440-4456). [PMID:35491243][10.1111/bph.15863]
10.Yao Xin-peng, Jiao Ting-ying, Jiang Yi-ming, Fan Shi-cheng, Zhao Ying-yuan, Yang Xiao, Gao Yue, Li Fei, Zhou Yan-ying, Chen Pan-pan, Huang Min, Bi Hui-chang. (2021) PXR mediates mifepristone-induced hepatomegaly in mice. ACTA PHARMACOLOGICA SINICA, 43 (1):(146-156). [PMID:33782543][10.1038/s41401-021-00633-4]
11.Chang Shu, Teng-Fei Li, Duo Li, Zhong-Qiu Li, Xing-Hua Xia. (2021) Barcode signal amplifying strategy for sensitive and accurate protein detection on LC-MS/MS. ANALYST, 146 (5):(1725-1733). [PMID:33459316][10.1039/D0AN01948H]
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