Grouped product items

SKU

Size

Availability

Price

Qty

M126999-200mg

200mg

Available within 8-12 weeks(?)

$46.90

M126999-1g

Available within 8-12 weeks(?)

$151.90

M126999-5g

In stock

$402.90

M126999-25g

25g

In stock

$1,409.90

Basic Description

Synonyms	RU486 \| RU 38486 \| 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST, ANTAGONIST
Mechanism of action	Progesterone receptor antagonist
Product Description	Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. A progesterone and glucocorticoid antagonist, suppresses VEGF production.

Product Properties

ALogP	3.8

Associated Targets(Human)

NR3C1 Tclin Glucocorticoid receptor (67 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PGR Tclin Progesterone receptor (57 Activities)

Discover Target: PGR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 (1 Activities)

Discover Target: NR1I2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen receptor (27 Activities)

Discover Target: AR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
INCHI	InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
InChi Key	VKHAHZOOUSRJNA-GCNJZUOMSA-N
Canonical SMILES	CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O
Isomeric SMILES	CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
WGK Germany	3
RTECS	KG2955000
PubChem CID	55245
Molecular Weight	429.59
Reaxy-Rn	5779404

Database links

DrugBank Ligand	DB00834
PubChem CID	55245
BindingDB Ligand	18627
Wikipedia	Mifepristone
CAS Registry No.	84371-65-3
ChEMBL Ligand	CHEMBL1276308
ChEBI	CHEBI:50692
NURSA Ligand	10.1621/ST5A19ZOKW
RCSB PDB Ligand	486
PEP	mifepristone
DrugCentral Ligand	1805

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot Number	Certificate Type	Date	Item
I2226309	Certificate of Analysis	Jul 10, 2024	M126999
I2226306	Certificate of Analysis	Jul 04, 2024	M126999
G2417847	Certificate of Analysis	Jun 29, 2024	M126999
G2417853	Certificate of Analysis	Jun 29, 2024	M126999
G2417854	Certificate of Analysis	Jun 29, 2024	M126999
G2417855	Certificate of Analysis	Jun 29, 2024	M126999
G2417856	Certificate of Analysis	Jun 29, 2024	M126999
I2226305	Certificate of Analysis	Jul 22, 2022	M126999
L2307160	Certificate of Analysis	Jul 22, 2022	M126999

Chemical and Physical Properties

Solubility	Soluble in water (partly), DMF (~30 mg/ml), ethanol (50 mg/ml), methanol, and DMSO (86 mg/ml at 25 °C).(Soluble): chloroform
Sensitivity	Heat sensitive
Specific Rotation[α]	141° (C=0.5,CHCl3)
Melt Point(°C)	195 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H360:May damage fertility or the unborn child H362:May cause harm to breast-fed children
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help.
WGK Germany	3
RTECS	KG2955000
Reaxy-Rn	5779404
Merck Index	6186

Alternative Products

Citations of This Product

1. Qi-qiang Zhang, Xue-mei Di, Xiang Cao, Yonghong Nie, Wen Shuai, Jun Li, Hai Zhang. (2023) Analysis of pharmacodynamic components, targets and synergistic action mechanism of Fuyuan Shenghua granule for the treatment of medical-induced incomplete abortion based on network pharmacology. JOURNAL OF ETHNOPHARMACOLOGY, (117118). [PMID:37659757]
2. Sheng Hu, Pei Shen, Bin Chen, Shao-Wen Tian, Yong You. (2022) Apelin-13 reduces lipopolysaccharide-induced neuroinflammation and cognitive impairment via promoting glucocorticoid receptor expression and nuclear translocation. NEUROSCIENCE LETTERS, 788 (136850). [PMID:36038029]
3. Mengru Bai, Mingyang Chen, Qingquan Zeng, Shuanghui Lu, Ping Li, Zhiyuan Ma, Nengming Lin, Caihong Zheng, Hui Zhou, Su Zeng, Dongli Sun, Huidi Jiang. (2022) Up-regulation of hepatic CD36 by increased corticosterone/cortisol levels via GR leads to lipid accumulation in liver and hypertriglyceridaemia during pregnancy. BRITISH JOURNAL OF PHARMACOLOGY, 179 (17): (4440-4456). [PMID:35491243]

References

1. Shannon S et al.. (2015) Dexamethasone-Mediated Activation of Fibronectin Matrix Assembly Reduces Dispersal of Primary Human Glioblastoma Cells.. PLoS One, 10 (8): (e0135951). [PMID:26284619]
2. Nair M et al.. (2018) Dexamethasone-Mediated Upregulation of Calreticulin Inhibits Primary Human Glioblastoma Dispersal Ex Vivo.. Int J Mol Sci, 19 (2): [PMID:29443896]
3. Zhang B et al.. (2020) Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling.. J Neuroinflammation, 17 (318). [PMID:33100225]
4. Wang C et al.. (2017) Experimental research on the relationship between the stiffness and the expressions of fibronectin proteins and adaptor proteins of rat trabecular meshwork cells.. BMC Ophthalmol, 17 (268). [PMID:29284449]
5. Karami Kheirabad M et al.. (2015) Expression of Melanocortin-4 Receptor mRNA in Male Rat Hypothalamus During Chronic Stress.. Int J Mol Cell Med, 4 (3): (182-7). [PMID:26629487]
6. Xiao R et al.. (2016) Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.. Cancer Immunol Res, 4 (6): (488-497). [PMID:27045020]
7. Qi-qiang Zhang, Xue-mei Di, Xiang Cao, Yonghong Nie, Wen Shuai, Jun Li, Hai Zhang. (2023) Analysis of pharmacodynamic components, targets and synergistic action mechanism of Fuyuan Shenghua granule for the treatment of medical-induced incomplete abortion based on network pharmacology. JOURNAL OF ETHNOPHARMACOLOGY, (117118). [PMID:37659757]
8. Sheng Hu, Pei Shen, Bin Chen, Shao-Wen Tian, Yong You. (2022) Apelin-13 reduces lipopolysaccharide-induced neuroinflammation and cognitive impairment via promoting glucocorticoid receptor expression and nuclear translocation. NEUROSCIENCE LETTERS, 788 (136850). [PMID:36038029]
9. Mengru Bai, Mingyang Chen, Qingquan Zeng, Shuanghui Lu, Ping Li, Zhiyuan Ma, Nengming Lin, Caihong Zheng, Hui Zhou, Su Zeng, Dongli Sun, Huidi Jiang. (2022) Up-regulation of hepatic CD36 by increased corticosterone/cortisol levels via GR leads to lipid accumulation in liver and hypertriglyceridaemia during pregnancy. BRITISH JOURNAL OF PHARMACOLOGY, 179 (17): (4440-4456). [PMID:35491243]

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Mifepristone - ≥98%, high purity , Progesterone receptor antagonist, CAS No.84371-65-3, Progesterone receptor antagonist