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mitemcinal , CAS No.154738-42-8, Agonist of motilin receptor

CAS#: 154738-42-8
PubChem CID: 177964

Item Number

M611894

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SKU	Size	Availability	Price	Qty
M611894-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M611894-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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motilin receptor Agonist

Synonyms

GM-611;GM611

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of motilin receptor

Associated Targets(Human)

MLNR Tchem Motilin receptor (1 Activities)

Discover Target: MLNR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MLNR Tchem Motilin receptor (1724 Activities)

Discover Target: MLNR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(1S,2R,3S,4S,5R,8R,9R,11S)-8-ethyl-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-2-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methyl-propan-2-ylamino)oxan-2-yl]oxy-9-methoxy-1,3,5,9,11,13-hexamethyl-7,15-dioxabicyclo[10.2.1]pentadec-12-ene-6,10-dione
INCHI	InChI=1S/C40H69NO12/c1-16-28-40(12,47-15)33(43)23(6)31-21(4)18-39(11,53-31)35(52-37-30(42)27(17-22(5)48-37)41(13)20(2)3)24(7)32(25(8)36(45)50-28)51-29-19-38(10,46-14)34(44)26(9)49-29/h20,22-30,32,34-35,37,42,44H,16-19H2,1-15H3/t22-,23+,24+,25-,26+,27+,28-,29+,30-,32+,34+,35-,37+,38-,39+,40-/m1/s1
InChi Key	BELMMAAWNYFCGF-AQBNEDITSA-N
Canonical SMILES	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@H]([C@]2(OC(=C(C)C2)[C@@H](C(=O)[C@]1(C)OC)C)C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C(C)C)C
Isomeric SMILES	CC[C@@H]1[C@@](C(=O)[C@H](C2=C(C[C@](O2)([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)OC)C)O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C(C)C)O)C)C)C)(C)OC
PubChem CID	177964

CAS Registry No.

Wikipedia

PubChem CID

ChEMBL Ligand

GPCRdb Ligand

References

1. Peeters TL. (2001) GM-611 (Chugai Pharmaceutical).. Curr Opin Investig Drugs, 2 (4): (555-7). [PMID:11566017]
2. McCallum RW, Cynshi O, Investigative Team. (2007) Clinical trial: effect of mitemcinal (a motilin agonist) on gastric emptying in patients with gastroparesis - a randomized, multicentre, placebo-controlled study.. Aliment Pharmacol Ther, 26 (8): (1121-30). [PMID:17894654]
3. McCallum RW, Cynshi O, US INVESTIGATIVE TEAM. (2007) Efficacy of mitemcinal, a motilin agonist, on gastrointestinal symptoms in patients with symptoms suggesting diabetic gastropathy: a randomized, multi-center, placebo-controlled trial.. Aliment Pharmacol Ther, 26 (1): (107-16). [PMID:17555427]
4. Onoma M, Ozaki K, Yogo K, Monnai M, Muramatsu H, Kamei K, Kawabe Y, Hayashi S, Shiga T, Matsuo S et al.. (2008) Mitemcinal (GM-611), an orally active motilin receptor agonist, improves delayed gastric emptying in a canine model of diabetic gastroparesis.. Clin Exp Pharmacol Physiol, 35 (7): (788-96). [PMID:18346169]
5. Takanashi H, Cynshi O. (2009) Motilides: a long and winding road: lessons from mitemcinal (GM-611) on diabetic gastroparesis.. Regul Pept, 155 (1-3): (18-23). [PMID:19345243]

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mitemcinal , CAS No.154738-42-8, Agonist of motilin receptor

Basic Description

Associated Targets(Human)

Names and Identifiers

Database links

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