Basic Description

Synonyms	KBioGR_000607 \| Mytozytrex \| KBio2_003175 \| Mitomycin (TN) \| NSC 26980 \| UGN-102 \| [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate \| 50-07-7 (non-salt) \| Aziri
Specifications & Purity	≥98%, from Streptomyces caespitosus
Biochemical and Physiological Mechanisms	Mitomycin C causes the cross-linking of double-stranded DNA, which results in mutagenesis, inhibition of DNA synthesis, initiation of DNA repair events, and activation of apoptosis. The capability to inhibit DNA synthesis is attributable to the aminoquino
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Description Mitomycin C is a systemic chemotherapy compound and an antibiotic obtained fromStreptomyces caespitosus. It is the first bioreductive alkylating agent to be identified and is a derivative of 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, L-methionine and carbamoyl phosphate.Chemical structure: AziridineMitomycin C fromStreptomyces caespitosushas been used for the treatment of feeder layers such as, PMEF (primary mouse embryonic fibroblasts) and CD1 mouse embryonic fibroblasts (MEFs) for the culture of hESCs (human embryonic stem cells). It has also been used for the treatment of BLC (basal-like cancer) cell line. λmax；216, 359 nm

Product Properties

ALogP	-0.4

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

Discover Target: Agtr2

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Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

Discover Target: Cckar

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Abcb1b P-glycoprotein 1 (174 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

Discover Target: Nos2

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Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

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Hdac6 Histone deacetylase 6 (222 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Caulobacter vibrioides (128 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Klebsiella pneumoniae (43867 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Salmonella typhimurium (15756 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Micrococcus luteus (7463 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Acinetobacter baumannii (41033 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bacillus subtilis (32866 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptomyces (126 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trypanosoma brucei brucei (13300 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cryptococcus neoformans (21258 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

B16 (5829 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CCRF S-180 (1031 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHO-AA8 (574 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHO-K1 (1115 Activities)

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DC3F (23 Activities)

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DC3F/AD-II (6 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EL4 (235 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EMT6 (738 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L1210 (27553 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDCK (10148 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P388 (20296 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P388/ADR (1216 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P388/S (109 Activities)

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Vero (26788 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

XC (7 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

C6 (2371 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

H4 (48 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NIH3T3 (5395 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

V79 (1637 Activities)

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B16-F10 (4610 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

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Raoultella planticola (618 Activities)

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Names and Identifiers

IUPAC Name	[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
INCHI	InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChi Key	NWIBSHFKIJFRCO-WUDYKRTCSA-N
Canonical SMILES	CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
Isomeric SMILES	CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
WGK Germany	3
Alternate CAS	1404-00-8
PubChem CID	5746
UN Number	2811
Packing Group	I
Molecular Weight	334.33
Beilstein	7231816

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

19 results found

Lot Number	Certificate Type	Date	Item
C2429862	Certificate of Analysis	Mar 14, 2024	M476633
C2429863	Certificate of Analysis	Mar 14, 2024	M476633
C2429864	Certificate of Analysis	Mar 14, 2024	M476633
L2320113	Certificate of Analysis	Sep 19, 2023	M476633
A2404381	Certificate of Analysis	Sep 19, 2023	M476633
J2326583	Certificate of Analysis	Sep 19, 2023	M476633
J2326582	Certificate of Analysis	Sep 19, 2023	M476633
J2326581	Certificate of Analysis	Sep 19, 2023	M476633
J2326541	Certificate of Analysis	Sep 19, 2023	M476633
D2318939	Certificate of Analysis	Mar 24, 2023	M476633
D2318940	Certificate of Analysis	Mar 24, 2023	M476633
D2318962	Certificate of Analysis	Mar 24, 2023	M476633
H2302248	Certificate of Analysis	Mar 24, 2023	M476633
H2315345	Certificate of Analysis	Mar 24, 2023	M476633
D2318934	Certificate of Analysis	Mar 24, 2023	M476633
D2318928	Certificate of Analysis	Mar 24, 2023	M476633
D2318927	Certificate of Analysis	Mar 24, 2023	M476633
D2318920	Certificate of Analysis	Mar 24, 2023	M476633
D2318919	Certificate of Analysis	Mar 24, 2023	M476633

Chemical and Physical Properties

Solubility	H2O: 4mL/vial, clear to slightly hazy, blue to purple (Stock solutions should be filter sterilized and stored at 2-8 °C in the dark.)
Sensitivity	Light sensitive；Heat sensitive；Moisture sensitive
Refractive Index	1.68 (Predicted)
Boil Point(°C)	581.8° C at 760 mmHg (Predicted)
Melt Point(°C)	64℃

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H351:Suspected of causing cancer H300:Fatal if swallowed
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice.
WGK Germany	3
Class	6.1
RIDADR	>360° C

Alternative Products

FAQs and Articles

FAQ

DNA Damage and Repair

Categories: Technical articles

Tags:

inhibitor DNA

Citations of This Product

1. Qunfei Tai, Hailong Yu, Mingxia Gao, Xiangmin Zhang. (2023) In Situ Capturing and Counting Device for the Specific Depletion and Purification of Cancer-Derived Exosomes. ANALYTICAL CHEMISTRY, [PMID:37609888]
2. Xuchen Feng, Jun Ge, Hui Fu, Lin Miao, Feng Zhao, Jingyu Wang, Yujiao Sun, Yingpeng Li, Yunfei Li. (2023) Discovery of small molecule β-catenin suppressors that enhance immunotherapy. BIOORGANIC CHEMISTRY, 139 (106754). [PMID:37536216]
3. Chen Yihuan, Dai Xiaoshuo, Chen Wei, Qiao Yan, Bai Ruihua, Duan Xiaoxuan, Zhang Kai, Chen Xinhuan, Li Xin, Mo Saijun, Cao Wenbo, Li Xiang, Liu Kangdong, Dong Ziming, Lu Jing. (2023) Diosmetin suppresses the progression of ESCC by CDK2/Rb/E2F2/RRM2 pathway and synergies with cisplatin. ONCOGENE, 42 (29): (2278-2293). [PMID:37349644]
4. Xiu Yanghui, Su Yu, Gao Lihua, Yuan Hui, Xu Sennan, Liu Ying, Qiu Yan, Liu Zhen, Li Yuhang. (2023) Corylin accelerated wound healing through SIRT1 and PI3K/AKT signaling: a candidate remedy for chronic non-healing wounds. Frontiers in Pharmacology, 14 [PMID:37266148]
5. Die Dong, Rimei Chen, Jihong Jia, Chao Zhao, Zhiping Chen, Qin Lu, Yupei Sun, Weiyi Huang, Chunfang Wang, Yao Li, Hui He. (2023) Tailoring and application of a multi-responsive cellulose nanofibre-based 3D nanonetwork wound dressing. CARBOHYDRATE POLYMERS, 305 (120542). [PMID:36737193]
6. Wang Wen-Wen, Yang Li-Jie, Guo Jun-Feng. (2023) Evaluation of the therapeutic effect of mitomycin-loaded hydrogel in inhibiting tumor-cell proliferation and invasion in pancreatic cancer. Materials Express, 13 (1): (81-84). [PMID:]
7. Xiaohua Xie, Xiaofeng Wu, Dongsheng Zhao, Ying Liu, Qiyue Du, Yitian Li, Yaping Xu, Yuhang Li, Yan Qiu, Yungang Yang. (2023) Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway. PHARMACOLOGICAL RESEARCH, 187 (106577). [PMID:36435270]

References

1. M Tomasz. (1995-09-01) Mitomycin C: small, fast and deadly (but very selective).. Chemistry & biology, 2 ((9)): (575-579). [PMID:9383461]
2. M P S Ishar,Tilak Raj,Satyam Kumar Agrawal,A K Saxena,Lakhwinder Singh,Rajinder Singh,Surinderjit Singh Bhella. (2008-08-19) Synthesis and cytotoxic activity of some novel polycyclic gamma-butyrolactones.. Bioorganic & medicinal chemistry letters, 18 ((17)): (4809-4812). [PMID:18707881]
3. Masaki Hikida,Stefano Casola,Noriko Takahashi,Tomohiro Kaji,Toshitada Takemori,Klaus Rajewsky,Tomohiro Kurosaki. (2009-03-11) PLC-gamma2 is essential for formation and maintenance of memory B cells.. The Journal of experimental medicine, 206 ((3)): (681-689). [PMID:19273623]
4. Ariana Jacome,Susana Navarro,Paula Río,Rosa M Yañez,Africa González-Murillo,M Luz Lozano,Maria Luisa Lamana,Julian Sevilla,Teresa Olive,Cristina Diaz-Heredia,Isabel Badell,Jesus Estella,Luis Madero,Guillermo Guenechea,José Casado,Jose C Segovia,Juan A Bueren. (2009-03-12) Lentiviral-mediated genetic correction of hematopoietic and mesenchymal progenitor cells from Fanconi anemia patients.. Molecular therapy : the journal of the American Society of Gene Therapy, 17 ((6)): (1083-1092). [PMID:19277017]
5. Marta Vergara-Irigaray,Jaione Valle,Nekane Merino,Cristina Latasa,Begoña García,Igor Ruiz de Los Mozos,Cristina Solano,Alejandro Toledo-Arana,José R Penadés,Iñigo Lasa. (2009-07-08) Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections.. Infection and immunity, 77 ((9)): (3978-3991). [PMID:19581398]
6. Tobias Dörr,Kim Lewis,Marin Vulić. (2009-12-17) SOS response induces persistence to fluoroquinolones in Escherichia coli.. PLoS genetics, 5 ((12)): (e1000760-e1000760). [PMID:20011100]
7. Minjun Chen,Vikrant Vijay,Qiang Shi,Zhichao Liu,Hong Fang,Weida Tong. (2011-06-01) FDA-approved drug labeling for the study of drug-induced liver injury.. Drug discovery today, 16 ((15-16)): (697-703). [PMID:21624500]
8. Ahmed Kamal,Y V V Srikanth,M Naseer Ahmed Khan,Md Ashraf,M Kashi Reddy,Farheen Sultana,Tandeep Kaur,Gousia Chashoo,Nitasha Suri,Irum Sehar,Zahoor A Wani,Arpita Saxena,Parduman R Sharma,Shashi Bhushan,Dilip M Mondhe,Ajit K Saxena. (2011-11-04) 2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers.. Bioorganic & medicinal chemistry, 19 ((23)): (7136-7150). [PMID:22047801]
9. I Kraicheva,I Tsacheva,E Vodenicharova,E Tashev,T Tosheva,A Kril,M Topashka-Ancheva,I Iliev,Ts Gerasimova,K Troev. (2011-12-07) Synthesis, antiproliferative activity and genotoxicity of novel anthracene-containing aminophosphonates and a new anthracene-derived Schiff base.. Bioorganic & medicinal chemistry, 20 ((1)): (117-124). [PMID:22142614]
10. Ashok Kumar Narsani,Partab Rai Nagdev,Maria Nazish Memon. (2013-03-06) Outcome of recurrent pterygium with intraoperative 0.02% mitomycin C and free flap limbal conjunctival autograft.. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 23 ((3)): (199-202). [PMID:23458043]
11. C Nieder. (2013-04-24) [Concurrent radiochemotherapy with 5-FU/mitomycin remains standard treatment for anal carcinoma. Long-term results of the phase III RTOG 98-11 trial].. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 189 ((6)): (512-513). [PMID:23609134]
12. Jesús Aranda,Margarita Poza,Miguel Shingu-Vázquez,Pilar Cortés,John D Boyce,Ben Adler,Jordi Barbé,Germán Bou. (2013-10-15) Identification of a DNA-damage-inducible regulon in Acinetobacter baumannii.. Journal of bacteriology, 195 ((24)): (5577-5582). [PMID:24123815]
13. Fang Gu,Xiuli Li,Jian Kong,Bing Pan,Min Sun,Lemin Zheng,Yuanqing Yao. (2013-10-16) VEGF111b, a new member of VEGFxxxb isoforms and induced by mitomycin C, inhibits angiogenesis.. Biochemical and biophysical research communications, 441 ((1)): (18-24). [PMID:24125722]
14. Sanjeev Dayal,Panagiotis Taflampas,Stefan Riss,Kandiah Chandrakumaran,Thomas D Cecil,Faheez Mohamed,Brendan J Moran. (2013-11-10) Complete cytoreduction for pseudomyxoma peritonei is optimal but maximal tumor debulking may be beneficial in patients in whom complete tumor removal cannot be achieved.. Diseases of the colon and rectum, 56 ((12)): (1366-1372). [PMID:24201390]
15. Nan Chen,Ji Zhang. (2013-11-21) [The mechanism and progress of topical application of mitomycin C as an adjunctive therapy for benign airway stenosis].. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 36 ((8)): (592-594). [PMID:24252736]
16. M Jiang,R Broering,M Trippler,L Poggenpohl,M Fiedler,G Gerken,M Lu,J F Schlaak. (2014-02-07) Toll-like receptor-mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigen.. Journal of viral hepatitis, 21 ((12)): (860-872). [PMID:24498958]
17. Chisa Ozaki,Satoshi Somamoto,Shingo Kawabata,Yasuhiko Tabata. (2014-06-19) Effect of an artificial silk elastin-like protein on the migration and collagen production of mouse fibroblasts.. Journal of biomaterials science. Polymer edition, 25 ((12)): (1266-1277). [PMID:24941248]
18. Rafael Duran,Julius Chapiro,Constantine Frangakis,MingDe Lin,Todd R Schlachter,Rüdiger E Schernthaner,Zhijun Wang,Lynn J Savic,Vania Tacher,Ihab R Kamel,Jean-François Geschwind. (2014-06-24) Uveal Melanoma Metastatic to the Liver: The Role of Quantitative Volumetric Contrast-Enhanced MR Imaging in the Assessment of Early Tumor Response after Transarterial Chemoembolization.. Translational oncology, 7 ((4)): (447-455). [PMID:24953419]
19. Hao Wang,Feng Qi,Xiangchen Dai,Weijun Tian,Tong Liu,Hongqiu Han,Bai Zhang,Hongyue Li,Zhixiang Zhang,Caigan Du. (2014-07-01) Requirement of B7-H1 in mesenchymal stem cells for immune tolerance to cardiac allografts in combination therapy with rapamycin.. Transplant immunology, 31 ((2)): (65-74). [PMID:24978830]
20. Yasuhiro Kazuki,Yuwna Yakura,Satoshi Abe,Mitsuhiko Osaki,Naoyo Kajitani,Kanako Kazuki,Shoko Takehara,Kazuhisa Honma,Hirofumi Suemori,Satoshi Yamazaki,Tetsushi Sakuma,Tsutomu Toki,Ritsuko Shimizu,Hiromitsu Nakauchi,Takashi Yamamoto,Mitsuo Oshimura. (2014-08-28) Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies.. Scientific reports, 4 (6136-6136). [PMID:25159877]
21. Hwayong Park,Youn-Hwan Hwang,Hye Jin Yang,Hyun-Kyu Kim,Kyung Seuk Song,Jin Yeul Ma. (2014-09-15) Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang.. Journal of ethnopharmacology, 156 (182-189). [PMID:25218323]
22. Haruki Horiguchi,Motoyoshi Endo,Yuji Miyamoto,Yasuo Sakamoto,Haruki Odagiri,Tetsuro Masuda,Tsuyoshi Kadomatsu,Hironori Tanoue,Ikuyo Motokawa,Kazutoyo Terada,Masaki Suimye Morioka,Ichiro Manabe,Hideo Baba,Yuichi Oike. (2014-10-08) Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling.. Cancer science, 105 ((12)): (1550-1559). [PMID:25287946]
23. Kohji Yamakage,Hajime Sui,Ryo Ohta,Tomoyasu Toyoizumi,Kumiko Kawakami,Hirotaka Matsumoto,Toshitaka Takahashi,Kiyoshi Sasaki,Mayu Ikezumi,Saki Negishi,Keisuke Izumi,Setsuko Todoriki,Kondo Takashi,Masakazu Furuta. (2014-10-26) Genotoxic potential and in vitro tumour-promoting potential of 2-dodecylcyclobutanone and 2-tetradecylcyclobutanone, two radiolytic products of fatty acids.. Mutation research. Genetic toxicology and environmental mutagenesis, 770 (95-104). [PMID:25344170]
24. Thomas R Geiger,Ngoc-Han Ha,Farhoud Faraji,Helen T Michael,Loren Rodriguez,Renard C Walker,Jeffery E Green,R Mark Simpson,Kent W Hunter. (2014-11-05) Functional analysis of prognostic gene expression network genes in metastatic breast cancer models.. PloS one, 9 ((11)): (e111813-e111813). [PMID:25368990]
25. Rabih El-Merahbi,Yen-Nien Liu,Assaad Eid,Georges Daoud,Leina Hosry,Alissar Monzer,Tarek H Mouhieddine,Aline Hamade,Fadia Najjar,Wassim Abou-Kheir. (2014-11-08) Berberis libanotica Ehrenb extract shows anti-neoplastic effects on prostate cancer stem/progenitor cells.. PloS one, 9 ((11)): (e112453-e112453). [PMID:25380390]
26. Marcio Fronza,Guilherme F Caetano,Marcel N Leite,Claudia S Bitencourt,Francisco W G Paula-Silva,Thiago A M Andrade,Marco A C Frade,Irmgard Merfort,Lúcia H Faccioli. (2014-11-14) Hyaluronidase modulates inflammatory response and accelerates the cutaneous wound healing.. PloS one, 9 ((11)): (e112297-e112297). [PMID:25393024]
27. Janine Müller,Christiana Ossig,Johannes F W Greiner,Stefan Hauser,Mareike Fauser,Darius Widera,Christian Kaltschmidt,Alexander Storch,Barbara Kaltschmidt. (2014-12-07) Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats.. Stem cells translational medicine, 4 ((1)): (31-43). [PMID:25479965]
28. Katie E Burrows,Celine Dumont,Clare L Thompson,Matthew C Catley,Kate L Dixon,Diane Marshall. (2014-12-30) OX40 blockade inhibits house dust mite driven allergic lung inflammation in mice and in vitro allergic responses in humans.. European journal of immunology, 45 ((4)): (1116-1128). [PMID:25545270]
29. Shu-I Yeh,Tsung-Chuan Ho,Show-Li Chen,Chie-Pein Chen,Huey-Chuan Cheng,Yu-Wen Lan,Jui-Wen Hsieh,Chin-Tien Wang,Yeou-Ping Tsao. (2015-02-14) Pigment Epithelial-Derived Factor Peptide Facilitates the Regeneration of a Functional Limbus in Rabbit Partial Limbal Deficiency.. Investigative ophthalmology & visual science, 56 ((4)): (2126-2134). [PMID:25678686]
30. Zaki Shaikhibrahim,Anne Offermann,Rebecca Halbach,Wenzel Vogel,Martin Braun,Glen Kristiansen,Friedrich Bootz,Jörg Wenzel,Ralf Mikut,Claudia Lengerke,Markus Reischl,Andreas Schröck,Sven Perner. (2015-03-21) Clinical and molecular implications of MED15 in head and neck squamous cell carcinoma.. The American journal of pathology, 185 ((4)): (1114-1122). [PMID:25791637]
31. Tero-Pekka Alastalo,Gun West,Song-Ping Li,Anni Keinänen,Mikko Helenius,Tiina Tyni,Risto Lapatto,Maila Turanlahti,Päivi Heikkilä,Helena Kääriäinen,Markku Laakso,Monika Mauermann,Harald Herrmann,Jaana Pihkala,Pekka Taimen. (2015-03-31) LMNA Mutation c.917T>G (p.L306R) Leads to Deleterious Hyper-Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and Premature Aging.. Human mutation, 36 ((7)): (694-703). [PMID:25820511]
32. Yan Chen,Jin Zhang,Yong Lu,Libo Wang. (2015-04-11) Immunosuppression in early postnatal days induces persistent and allergen-specific immune tolerance to asthma in adult mice.. PloS one, 10 ((4)): (e0122990-e0122990). [PMID:25860995]
33. Chao Zhu,Chunxuan Cao,Li Dai,Jie Yuan,Shengnan Li. (2015-04-15) Corticotrophin-releasing factor participates in S1PR3-dependent cPLA2 expression and cell motility in vascular smooth muscle cells.. Vascular pharmacology, 71 (116-126). [PMID:25869501]
34. Paul J Gokhale,Janice K Au-Young,SriVidya Dadi,David N Keys,Neil J Harrison,Mark Jones,Shamit Soneji,Tariq Enver,Jon K Sherlock,Peter W Andrews. (2015-04-16) Culture adaptation alters transcriptional hierarchies among single human embryonic stem cells reflecting altered patterns of differentiation.. PloS one, 10 ((4)): (e0123467-e0123467). [PMID:25875838]
35. Xiuli Li,Fang Gu,Chenguang Niu,Yuanfen Wang,Zhongyu Liu,Na Li,Bing Pan,Dan He,Jian Kong,Shaobo Zhang,Xu Wang,Yuanqing Yao,Lemin Zheng. (2015-05-21) VEGF111b, a C-terminal splice variant of VEGF-A and induced by mitomycin C, inhibits ovarian cancer growth.. Journal of translational medicine, 13 (164-164). [PMID:25990504]
36. Carola H Schrader,Markus Kolb,Karim Zaoui,Christa Flechtenmacher,Niels Grabe,Klaus-Josef Weber,Thomas Hielscher,Peter K Plinkert,Jochen Hess. (2015-05-21) Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients.. Molecular cancer, 14 (107-107). [PMID:25990935]
37. Yuan Zhou,Yongzheng He,Richa Sharma,Wen Xing,Selina A Estwick,Xiaohua Wu,Steven D Rhodes,Mingjiang Xu,Feng-Chun Yang. (2015-06-04) Hyperactive RAS/PI3-K/MAPK Signaling Cascade in Migration and Adhesion of Nf1 Haploinsufficient Mesenchymal Stem/Progenitor Cells.. International journal of molecular sciences, 16 ((6)): (12345-12359). [PMID:26039236]
38. Jaeyop Lee,Gaëlle Breton,Arafat Aljoufi,Yu Jerry Zhou,Sarah Puhr,Michel C Nussenzweig,Kang Liu. (2015-06-10) Clonal analysis of human dendritic cell progenitor using a stromal cell culture.. Journal of immunological methods, 425 (21-26). [PMID:26056939]
39. Hanh Nguyen-Kim,Yvan Bettarel,Thierry Bouvier,Corinne Bouvier,Hai Doan-Nhu,Lam Nguyen-Ngoc,Thuy Nguyen-Thanh,Huy Tran-Quang,Justine Brune. (2015-06-21) Coral Mucus Is a Hot Spot for Viral Infections.. Applied and environmental microbiology, 81 ((17)): (5773-5783). [PMID:26092456]
40. Yong Joo Lee,Myoung-Eun Han,Su-Jin Baek,Seon-Young Kim,Sae-Ock Oh. (2015-06-26) MED30 Regulates the Proliferation and Motility of Gastric Cancer Cells.. PloS one, 10 ((6)): (e0130826-e0130826). [PMID:26110885]
41. Maria A Hoelzl,Karin Heby-Henricson,Ganna Bilousova,Björn Rozell,Raoul V Kuiper,Maria Kasper,Rune Toftgård,Stephan Teglund. (2015-07-16) Suppressor of Fused Plays an Important Role in Regulating Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo.. Stem cells and development, 24 ((21)): (2547-2560). [PMID:26176320]
42. Shanmei Xu,Minxiao Chen,Wenbo Chen,Junguo Hui,Jiansong Ji,Shuping Hu,Jianmin Zhou,Yi Wang,Guang Liang. (2015-11-11) Chemopreventive effect of chalcone derivative, L2H17, in colon cancer development.. BMC cancer, 15 (870-870). [PMID:26552551]
43. Raffaella Vescovi,Matilde Monti,Daniele Moratto,Lucia Paolini,Francesca Consoli,Luisa Benerini,Laura Melocchi,Stefano Calza,Mariella Chiudinelli,Giulio Rossi,Mattia Bugatti,Michele Maio,Ester Fonsatti,Camillo Farisoglio,Michele Simbolo,Camillo Almici,Rosanna Verardi,Aldo Scarpa,Paolo Bergese,Ausilia Manganoni,Fabio Facchetti,William Vermi. (2018-11-08) Collapse of the Plasmacytoid Dendritic Cell Compartment in Advanced Cutaneous Melanomas by Components of the Tumor Cell Secretome.. Cancer immunology research, 7 ((1)): (12-28). [PMID:30401679]
44. Hanlin Ma,Yingwei Li,Xiangxiang Wang,Huan Wu,Gonghua Qi,Rongrong Li,Ning Yang,Min Gao,Shi Yan,Cunzhong Yuan,Beihua Kong. (2019-02-20) PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma.. Cell death & disease, 10 ((3)): (166-166). [PMID:30778048]
45. Carla Maria Figueiredo de Carvalho Miranda,Jacinthe Therrien,Luciano César Pereira Campos Leonel,Olivia Eilers Smith,Maria Angélica Miglino,Lawrence Charles Smith. (2020-06-15) Decellularization of Extracellular Matrix from Equine Skeletal Muscle.. Journal of equine veterinary science, 90 (102962-102962). [PMID:32534761]
46. Alexis Laurent,Poyin Lin,Corinne Scaletta,Nathalie Hirt-Burri,Murielle Michetti,Anthony S de Buys Roessingh,Wassim Raffoul,Bin-Ru She,Lee Ann Applegate. (2020-07-09) Bringing Safe and Standardized Cell Therapies to Industrialized Processing for Burns and Wounds.. Frontiers in bioengineering and biotechnology, 8 (581-581). [PMID:32637400]
47. Yuki Kiyokawa,Masahiro Sato,Hirofumi Noguchi,Emi Inada,Yoko Iwase,Naoko Kubota,Tadashi Sawami,Miho Terunuma,Takeyasu Maeda,Haruaki Hayasaki,Issei Saitoh. (2020-09-06) Drug-Induced Naïve iPS Cells Exhibit Better Performance than Primed iPS Cells with Respect to the Ability to Differentiate into Pancreatic β-Cell Lineage.. Journal of clinical medicine, 9 ((9)): [PMID:32887316]
48. Michael J Pokrass,Kathleen A Ryan,Tianchi Xin,Brittany Pielstick,Winston Timp,Valentina Greco,Sergi Regot. (2020-10-23) Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo.. Developmental cell, 55 ((3)): (328-340). [PMID:33091369]
49. Aritro Nath,Amrita Oak,Kevin Y Chen,Irene Li,R Chauncey Splichal,Jason Portis,Sean Foster,S Patrick Walton,Christina Chan. (2020-10-28) Palmitate-Induced IRE1-XBP1-ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration.. Molecular cancer research : MCR, 19 ((2)): (240-248). [PMID:33106375]
50. Harsha Nagar,Sungmin Kim,Ikjun Lee,Seonhee Kim,Su-Jeong Choi,Shuyu Piao,Byeong Hwa Jeon,Sang-Ha Oh,Cuk-Seong Kim. (2021-01-14) Downregulation of CR6-interacting factor 1 suppresses keloid fibroblast growth via the TGF-β/Smad signaling pathway.. Scientific reports, 11 ((1)): (500-500). [PMID:33436666]
51. Xinhui Wu,Vicky Verschut,Manon E Woest,John-Poul Ng-Blichfeldt,Ana Matias,Gino Villetti,Alessandro Accetta,Fabrizio Facchinetti,Reinoud Gosens,Loes E M Kistemaker. (2021-02-09) Rho-Kinase 1/2 Inhibition Prevents Transforming Growth Factor-β-Induced Effects on Pulmonary Remodeling and Repair.. Frontiers in pharmacology, 11 (609509-609509). [PMID:33551810]
52. Kyung Min Lim,Ahmed Abdal Dayem,Yujin Choi,Yoonjoo Lee,Jongyub An,Minchan Gil,Soobin Lee,Hee Jeong Kwak,Balachandar Vellingirl,Hyun Jin Shin,Ssang-Goo Cho. (2021-08-28) High Therapeutic and Esthetic Properties of Extracellular Vesicles Produced from the Stem Cells and Their Spheroids Cultured from Ocular Surgery-Derived Waste Orbicularis Oculi Muscle Tissues.. Antioxidants (Basel, Switzerland), 10 ((8)): [PMID:34439540]
53. S Kinoshita,K Uzu,K Nakano,M Shimizu,T Takahashi. (1971-02-01) Mitomycin derivatives. 1. Preparation of mitosane and mitosene compounds and their biological activities.. Journal of medicinal chemistry, 14 ((2)): (103-109). [PMID:5544392]
54. Sham M Sondhi,Reshma Rani,Jaiveer Singh,Partha Roy,S K Agrawal,A K Saxena. (2010-03-02) Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives.. Bioorganic & medicinal chemistry letters, 20 ((7)): (2306-2310). [PMID:20188544]
55. Dodanim Talavera-Adame,Gordon Wu,Yao He,Tina T Ng,Ankur Gupta,Silvia Kurtovic,Jae Y Hwang,Daniel L Farkas,Donald C Dafoe. (2011-02-08) Endothelial cells in co-culture enhance embryonic stem cell differentiation to pancreatic progenitors and insulin-producing cells through BMP signaling.. Stem cell reviews, 7 ((3)): (532-543). [PMID:21298405]
56. Allison Sang,Haitao Niu,Jaime Cullen,Seung Chul Choi,Ying Yi Zheng,Haowei Wang,Mark J Shlomchik,Laurence Morel. (2014-07-13) Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model.. Journal of immunology (Baltimore, Md. : 1950), 193 ((4)): (1609-1621). [PMID:25015835]
57. Elena Ciaglia,Simona Pisanti,Paola Picardi,Chiara Laezza,Silvio Sosa,Aurelia Tubaro,Mario Vitale,Patrizia Gazzerro,Anna Maria Malfitano,Maurizio Bifulco. (2014-07-27) N6-isopentenyladenosine affects cytotoxic activity and cytokines production by IL-2 activated NK cells and exerts topical anti-inflammatory activity in mice.. Pharmacological research, 89 (1-10). [PMID:25063359]
58. Yinan Liu,Peng Li,Kaiyu Liu,Qihua He,Shuo Han,Xiaofeng Sun,Tao Li,Li Shen. (2014-10-15) Timely inhibition of Notch signaling by DAPT promotes cardiac differentiation of murine pluripotent stem cells.. PloS one, 9 ((10)): (e109588-e109588). [PMID:25313563]
59. Jaeyop Lee,Gaëlle Breton,Thiago Yukio Kikuchi Oliveira,Yu Jerry Zhou,Arafat Aljoufi,Sarah Puhr,Mark J Cameron,Rafick-Pierre Sékaly,Michel C Nussenzweig,Kang Liu. (2015-02-18) Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow.. The Journal of experimental medicine, 212 ((3)): (385-399). [PMID:25687283]
60. Qunfei Tai, Hailong Yu, Mingxia Gao, Xiangmin Zhang. (2023) In Situ Capturing and Counting Device for the Specific Depletion and Purification of Cancer-Derived Exosomes. ANALYTICAL CHEMISTRY, [PMID:37609888]
61. Xuchen Feng, Jun Ge, Hui Fu, Lin Miao, Feng Zhao, Jingyu Wang, Yujiao Sun, Yingpeng Li, Yunfei Li. (2023) Discovery of small molecule β-catenin suppressors that enhance immunotherapy. BIOORGANIC CHEMISTRY, 139 (106754). [PMID:37536216]
62. Chen Yihuan, Dai Xiaoshuo, Chen Wei, Qiao Yan, Bai Ruihua, Duan Xiaoxuan, Zhang Kai, Chen Xinhuan, Li Xin, Mo Saijun, Cao Wenbo, Li Xiang, Liu Kangdong, Dong Ziming, Lu Jing. (2023) Diosmetin suppresses the progression of ESCC by CDK2/Rb/E2F2/RRM2 pathway and synergies with cisplatin. ONCOGENE, 42 (29): (2278-2293). [PMID:37349644]
63. Xiu Yanghui, Su Yu, Gao Lihua, Yuan Hui, Xu Sennan, Liu Ying, Qiu Yan, Liu Zhen, Li Yuhang. (2023) Corylin accelerated wound healing through SIRT1 and PI3K/AKT signaling: a candidate remedy for chronic non-healing wounds. Frontiers in Pharmacology, 14 [PMID:37266148]
64. Die Dong, Rimei Chen, Jihong Jia, Chao Zhao, Zhiping Chen, Qin Lu, Yupei Sun, Weiyi Huang, Chunfang Wang, Yao Li, Hui He. (2023) Tailoring and application of a multi-responsive cellulose nanofibre-based 3D nanonetwork wound dressing. CARBOHYDRATE POLYMERS, 305 (120542). [PMID:36737193]
65. Wang Wen-Wen, Yang Li-Jie, Guo Jun-Feng. (2023) Evaluation of the therapeutic effect of mitomycin-loaded hydrogel in inhibiting tumor-cell proliferation and invasion in pancreatic cancer. Materials Express, 13 (1): (81-84). [PMID:]
66. Xiaohua Xie, Xiaofeng Wu, Dongsheng Zhao, Ying Liu, Qiyue Du, Yitian Li, Yaping Xu, Yuhang Li, Yan Qiu, Yungang Yang. (2023) Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway. PHARMACOLOGICAL RESEARCH, 187 (106577). [PMID:36435270]

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SKU	Size	Availability	Price
M476633-25mg	25mg	In stock	$73.90
M476633-100mg	100mg	In stock	$204.90
M476633-250mg	250mg	In stock	$357.90
M476633-1g	1g	In stock	$999.90

Mitomycin C - from Streptomyces caespitosus, 98%, high purity , CAS No.50-07-7