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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M339846-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $14.90 | |
M339846-25mg | 25mg | In stock | $28.90 | |
M339846-100mg | 100mg | In stock | $94.90 | |
M339846-250mg | 250mg | In stock | $213.90 | |
M339846-1g | 1g | In stock | $769.90 |
a type II topoisomerase inhibitor
Synonyms | mitoxantrone | 65271-80-9 | Mitozantrone | Mitoxanthrone | Mitoxantron | DHAQ | Mitoxantrona | Mitoxantronum | Misostol | Mitoxantrone [INN] | Mitoxantronum [INN-Latin] | Mitoxantrona [INN-Spanish] | CCRIS 7604 | NSC 279836 | NSC-279836 | UNII-BZ114NVM5P | DHAD | BZ114NVM5P | NSC279836 | 1,4- |
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Specifications & Purity | Moligand™, ≥97% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of DNA topoisomerase II alpha |
Product Description | Mitoxantrone is a DNA intercalating drug that inhibits DNA synthesis and is used as an anti-cancer agent. Mitoxantrone is an inhibitor of Topo II. |
pKa | pKa: 7.08 (Predicted), pKa: 9.27 (Predicted) |
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Ki Data | mAChR M2: Ki= 77.9 nM (human); mAChR M4: Ki= 89.8 nM (human); mAChR M1: Ki= 0.18 μM (human); SR-2C: Ki= 1.87 μM (human); HERG: Ki= 2.94 μM (human) |
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Pubchem Sid | 488179822 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179822 |
IUPAC Name | 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione |
INCHI | InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2 |
InChi Key | KKZJGLLVHKMTCM-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO |
Isomeric SMILES | C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO |
RTECS | CB5748500 |
PubChem CID | 4212 |
Molecular Weight | 444.48 |
Beilstein | 2795126 |
DrugBank Ligand | DB01204 |
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PubChem CID | 4212 |
CAS Registry No. | 65271-80-9 |
ChEMBL Ligand | CHEMBL58 |
Wikipedia | Mitoxantrone |
RCSB PDB Ligand | MIX |
PEP | mitoxantrone |
DrugCentral Ligand | 1821 |
PubChem SID | 488179822 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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D2424318 | Certificate of Analysis | Mar 08, 2024 | M339846 |
C2405537 | Certificate of Analysis | Feb 05, 2024 | M339846 |
F2421059 | Certificate of Analysis | Feb 05, 2024 | M339846 |
C2405543 | Certificate of Analysis | Feb 05, 2024 | M339846 |
C2405542 | Certificate of Analysis | Feb 05, 2024 | M339846 |
C2405541 | Certificate of Analysis | Feb 05, 2024 | M339846 |
C2405540 | Certificate of Analysis | Feb 05, 2024 | M339846 |
C2405539 | Certificate of Analysis | Feb 05, 2024 | M339846 |
C2405538 | Certificate of Analysis | Feb 05, 2024 | M339846 |
C2405536 | Certificate of Analysis | Feb 05, 2024 | M339846 |
C2315005 | Certificate of Analysis | Jan 05, 2023 | M339846 |
C2315043 | Certificate of Analysis | Jan 05, 2023 | M339846 |
C2315040 | Certificate of Analysis | Jan 05, 2023 | M339846 |
C2315034 | Certificate of Analysis | Jan 05, 2023 | M339846 |
C2315033 | Certificate of Analysis | Jan 05, 2023 | M339846 |
C2315032 | Certificate of Analysis | Jan 05, 2023 | M339846 |
C2315029 | Certificate of Analysis | Jan 05, 2023 | M339846 |
C2315023 | Certificate of Analysis | Jan 05, 2023 | M339846 |
Solubility | Slightly soluble in (methanol); insoluble in (water, acetone, chloroform) |
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Sensitivity | Heat sensitive |
Refractive Index | n20D1.71 |
Boil Point(°C) | ~805.7° C at 760 mmHg (Predicted) |
Melt Point(°C) | 170-174° C |
Pictogram(s) | GHS08, GHS09 |
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Signal | Warning |
Hazard Statements | H351:Suspected of causing cancer H411:Toxic to aquatic life with long lasting effects |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P391:Collect spillage. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
RTECS | CB5748500 |
Merck Index | 6217 |
Starting at $359.90
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1. Zhi Li, Shuhua Han. (2022) A Chemosensor of 1,8-Dihydroxyanthraquinone PMOs Prepared in a Ternary Deep Eutectic Solvent for the Sensitive Detection of Cu2+. ACS Omega, 7 (26): (22613–22625). [PMID:35811913] |
1. Zhi Li, Shuhua Han. (2022) A Chemosensor of 1,8-Dihydroxyanthraquinone PMOs Prepared in a Ternary Deep Eutectic Solvent for the Sensitive Detection of Cu2+. ACS Omega, 7 (26): (22613–22625). [PMID:35811913] |