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MK-1775 - 98%, high purity , Serine/threonine-protein kinase WEE1 inhibitor, CAS No.955365-80-7, Serine/threonine-protein kinase WEE1 inhibitor

Specifications & Purity:  98%
Item Number
M127160
Grouped product items
SKUSizeAvailabilityPrice Qty
M127160-5mg
5mg
In stock
$48.90
M127160-10mg
10mg
In stock
$78.90
M127160-25mg
25mg
In stock
$96.90
M127160-50mg
50mg
In stock
$112.90
M127160-100mg
100mg
In stock
$142.90
M127160-500mg
500mg
In stock
$643.90
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Potent and selective small-molecule inhibitor of Wee1 kinase

View related series
WEE1 G2 checkpoint kinase Inhibitor

Basic Description

SynonymsMK-1775|955365-80-7|Adavosertib|MK1775|AZD1775|MK 1775|AZD-1775|AZD 1775|1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one|2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-m
Specifications & Purity98%
Storage TempStore at -20°C
Shipped InDry ice
Action TypeINHIBITOR
Mechanism of actionSerine/threonine-protein kinase WEE1 inhibitor

Product Properties

ALogP3.1

Associated Targets

JAK3 Tclin Tyrosine-protein kinase JAK3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PLK1 Tchem Serine/threonine-protein kinase PLK1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

WEE1 Tchem Wee1-like protein kinase 7 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

WEE2 Tchem Wee1-like protein kinase 2 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADK Tchem Adenosine kinase 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one
INCHI InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31)
InChi Key BKWJAKQVGHWELA-UHFFFAOYSA-N
Canonical SMILES CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
Isomeric SMILES CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
PubChem CID 24856436
Molecular Weight 500.61

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6 results found

Lot NumberCertificate TypeDateItem
F2220247Certificate of AnalysisApr 02, 2024 M127160
F2220261Certificate of AnalysisApr 02, 2024 M127160
F2220262Certificate of AnalysisApr 02, 2024 M127160
F2220263Certificate of AnalysisApr 02, 2024 M127160
F2220457Certificate of AnalysisApr 02, 2024 M127160
F2220459Certificate of AnalysisApr 02, 2024 M127160

Chemical and Physical Properties

SolubilityDMSO 80 mg/mL Water 0.0001 mg/mL Ethanol <1 mg/mL

Related Documents

 SDS

 Specification Sheet

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