Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

MK-2461 - 98%, high purity , Hepatocyte growth factor receptor inhibitor, CAS No.917879-39-1, Hepatocyte growth factor receptor inhibitor

Item Number
M129777
Grouped product items
SKUSizeAvailabilityPrice Qty
M129777-1mg
1mg
In stock
$47.90
M129777-5mg
5mg
In stock
$195.90
M129777-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$347.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET
View related series
c-Met/HGFR fibroblast growth factor receptor 1 Inhibitor fibroblast growth factor receptor 2 Inhibitor fibroblast growth factor receptor 3 Inhibitor fms related receptor tyrosine kinase 1 Inhibitor fms related receptor tyrosine kinase 3 Inhibitor fms related receptor tyrosine kinase 4 Inhibitor kinase insert domain receptor Inhibitor macrophage stimulating 1 receptor Inhibitor MER proto-oncogene，tyrosine kinase Inhibitor MET proto-oncogene，receptor tyrosine kinase Inhibitor neurotrophic receptor tyrosine kinase 1 Inhibitor neurotrophic receptor tyrosine kinase 2 Inhibitor platelet derived growth factor receptor beta Inhibitor Protein Tyrosine Kinase/RTK

Basic Description

SynonymsSCHEMBL93526 | NCGC00346695-05 | CCG-264723 | FT-0631528 | NSC800795 | NSC-800795 | EX-A1566 | SY003220 | UNII-4200RD53XF | s2774 | AS-16288 | F85378 | NCGC00346695-01 | Racemic solketal | Q27086785 | JGEBLDKNWBUGRZ-HXUWFJFHSA-N | NSC764580 | NSC-764580 |
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionHepatocyte growth factor receptor inhibitor

Product Properties

ALogP1.2

Associated Targets(Human)

MST1R Tchem Macrophage-stimulating protein receptor (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FLT4 Tclin Vascular endothelial growth factor receptor 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FGFR1 Tclin Fibroblast growth factor receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FGFR2 Tclin Fibroblast growth factor receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FGFR3 Tclin Fibroblast growth factor receptor 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MET Tclin Hepatocyte growth factor receptor (15 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MERTK Tchem Tyrosine-protein kinase Mer (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDGFRB Tclin Platelet-derived growth factor receptor beta (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FLT1 Tclin Vascular endothelial growth factor receptor 1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KDR Tclin Vascular endothelial growth factor receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NTRK2 Tclin BDNF/NT-3 growth factors receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NTRK1 Tclin High affinity nerve growth factor receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 14-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
INCHI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
InChi Key JGEBLDKNWBUGRZ-HXUWFJFHSA-N
Canonical SMILES CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)CC5COCCO5)N=C2
Isomeric SMILES CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)C[C@@H]5COCCO5)N=C2
PubChem CID 44137946
Molecular Weight 495.55

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateItem
I2203357Certificate of AnalysisJun 25, 2022 M129777
I2203359Certificate of AnalysisJun 25, 2022 M129777
I2203363Certificate of AnalysisJun 25, 2022 M129777

Chemical and Physical Properties

Solubility≥24.8 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Related Documents

 SDS

 Specification Sheet

References

1. Pan BS, Chan GK, Chenard M, Chi A, Davis LJ, Deshmukh SV, Gibbs JB, Gil S, Hang G, Hatch H et al..  (2010)  MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor..  Cancer Res,  70  (4): (1524-33).  [PMID:20145145] [10.1021/op500134e]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.