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MK-2461 - 98%, high purity , Hepatocyte growth factor receptor inhibitor, CAS No.917879-39-1, Hepatocyte growth factor receptor inhibitor

Item Number
M129777
Grouped product items
SKUSizeAvailabilityPrice Qty
M129777-1mg
1mg
In stock
$47.90
M129777-5mg
5mg
In stock
$195.90
M129777-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$347.90
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View related series
fibroblast growth factor receptor 1 Inhibitor fibroblast growth factor receptor 2 Inhibitor fibroblast growth factor receptor 3 Inhibitor fms related receptor tyrosine kinase 1 Inhibitor fms related receptor tyrosine kinase 3 Inhibitor fms related receptor tyrosine kinase 4 Inhibitor kinase insert domain receptor Inhibitor macrophage stimulating 1 receptor Inhibitor MER proto-oncogene，tyrosine kinase Inhibitor MET proto-oncogene，receptor tyrosine kinase Inhibitor neurotrophic receptor tyrosine kinase 1 Inhibitor neurotrophic receptor tyrosine kinase 2 Inhibitor platelet derived growth factor receptor beta Inhibitor

Basic Description

SynonymsSCHEMBL93526 | NCGC00346695-05 | CCG-264723 | FT-0631528 | NSC800795 | NSC-800795 | EX-A1566 | SY003220 | UNII-4200RD53XF | s2774 | AS-16288 | F85378 | NCGC00346695-01 | Racemic solketal | Q27086785 | JGEBLDKNWBUGRZ-HXUWFJFHSA-N | NSC764580 | NSC-764580 |
Specifications & Purity98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionHepatocyte growth factor receptor inhibitor

Product Properties

ALogP1.2

Associated Targets(Human)

MST1R Tchem Macrophage-stimulating protein receptor (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FLT4 Tclin Vascular endothelial growth factor receptor 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FGFR1 Tclin Fibroblast growth factor receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FGFR2 Tclin Fibroblast growth factor receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FGFR3 Tclin Fibroblast growth factor receptor 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MET Tclin Hepatocyte growth factor receptor (15 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MERTK Tchem Tyrosine-protein kinase Mer (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDGFRB Tclin Platelet-derived growth factor receptor beta (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FLT1 Tclin Vascular endothelial growth factor receptor 1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KDR Tclin Vascular endothelial growth factor receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NTRK2 Tclin BDNF/NT-3 growth factors receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NTRK1 Tclin High affinity nerve growth factor receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 14-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
INCHI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
InChi Key JGEBLDKNWBUGRZ-HXUWFJFHSA-N
Canonical SMILES CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)CC5COCCO5)N=C2
Isomeric SMILES CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)C[C@@H]5COCCO5)N=C2
PubChem CID 44137946
Molecular Weight 495.55

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
I2203359Certificate of AnalysisJun 18, 2024 M129777
I2203363Certificate of AnalysisJun 18, 2024 M129777
I2203357Certificate of AnalysisJun 25, 2022 M129777

Chemical and Physical Properties

Solubility≥24.8 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Related Documents

 SDS

 Specification Sheet

References

1. Pan BS, Chan GK, Chenard M, Chi A, Davis LJ, Deshmukh SV, Gibbs JB, Gil S, Hang G, Hatch H et al..  (2010)  MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor..  Cancer Res,  70  (4): (1524-33).  [PMID:20145145]

Solution Calculators

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