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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M127183-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $189.90 | |
M127183-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $259.90 | |
M127183-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $899.90 |
Synonyms | MK2894 | MK-2894 | 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid | 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}-carbonyl)amino]cyclopropyl}benzoic Acid | DTXSID60648063 | MK 2894 | HY |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | MK-2894, a highly potent and selective second generation EP4 antagonist.MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammat |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of EP 4 receptor |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-[1-[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carbonyl]amino]cyclopropyl]benzoic acid |
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INCHI | InChI=1S/C25H22F3NO3S/c1-14-20(13-16-3-7-19(8-4-16)25(26,27)28)21(15(2)33-14)22(30)29-24(11-12-24)18-9-5-17(6-10-18)23(31)32/h3-10H,11-13H2,1-2H3,(H,29,30)(H,31,32) |
InChi Key | QJZQFVRFJCGDKF-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F |
Isomeric SMILES | CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F |
PubChem CID | 24952929 |
Molecular Weight | 473.51 |
PubChem CID | 24952929 |
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ChEMBL Ligand | CHEMBL597997 |
CAS Registry No. | 1006036-87-8 |
GPCRdb Ligand | MK-2894 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2429348 | Certificate of Analysis | May 25, 2024 | M127183 |
H2429354 | Certificate of Analysis | May 25, 2024 | M127183 |
H2429355 | Certificate of Analysis | May 25, 2024 | M127183 |
H2429356 | Certificate of Analysis | May 25, 2024 | M127183 |
H2429357 | Certificate of Analysis | May 25, 2024 | M127183 |
H2429366 | Certificate of Analysis | May 25, 2024 | M127183 |
Solubility | DMSO |
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Starting at $204.90