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MK 571 sodium salt (L 660711 sodium salt) - 10mM in DMSO, high purity , CAS No.115104-28-4

Moligand™
10mM in DMSO

CAS#: 115104-28-4
Formula: C₂₆H₂₇ClN₂O₃S₂
Molecular Weight: 515.09
PubChem CID: 5281888

Item Number

M420726

Grouped product items
SKU	Size	Availability	Price	Qty
M420726-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$241.90

Potent, selective and competitive CysLT 1 receptor antagonist

Basic Description

Synonyms	MK 571\|115104-28-4\|MK-571\|L-660711\|L 660711\|MK 0571\|CHEMBL15177\|76LB1G2X6V\|CHEBI:6619\|3-[[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-[3-(dimethylamino)-3-oxopropyl]sulfanylmethyl]sulfanylpropanoic acid\|Propanoic acid, 3-(((3-((1E)-2-(7-chloro-2-quino
Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	Potent, selective and competitive CysLT 1 receptor antagonist (IC 50 = 1.5 nM, LTD 4 ). Potent MRP1 inhibitor. Shows anti-ischemic, anti-inflammatory and antinociceptive effects in vivo. Orally active.
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™

Associated Targets

GMNN Tbio Geminin 0 Activities

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RORC Tchem Nuclear receptor ROR-gamma 0 Activities

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

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VDR Tclin Vitamin D3 receptor 0 Activities

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ABCB1 Tchem Multidrug resistance protein 1 0 Activities

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KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 0 Activities

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PMP22 Tbio Peripheral myelin protein 22 0 Activities

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ABCC2 Tchem Canalicular multispecific organic anion transporter 1 0 Activities

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ABCC3 Tbio Canalicular multispecific organic anion transporter 2 0 Activities

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ABCC5 Tchem Multidrug resistance-associated protein 5 0 Activities

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ABCC4 Tchem Multidrug resistance-associated protein 4 0 Activities

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ABCC6 Tbio Multidrug resistance-associated protein 6 0 Activities

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CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 1 Activities

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ABCG2 Tchem ATP-binding cassette sub-family G member 2 0 Activities

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ABCB11 Tchem Bile salt export pump 0 Activities

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ABCC11 Tbio ATP-binding cassette sub-family C member 11 0 Activities

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ABCC1 Tchem Multidrug resistance-associated protein 1 4 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-[3-(dimethylamino)-3-oxopropyl]sulfanylmethyl]sulfanylpropanoic acid
INCHI	InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+
InChi Key	AXUZQJFHDNNPFG-UXBLZVDNSA-N
Canonical SMILES	CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O
Isomeric SMILES	CN(C)C(=O)CCSC(C1=CC=CC(=C1)/C=C/C2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O
Alternate CAS	115104-28-4
PubChem CID	5281888
MeSH Entry Terms	(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)((3-dimethylamino-3-oxopropyl)thio)methyl)thiopropanoic acid;L 660,711;L 660711;L-660711;MK 0571;MK 0679;MK 571;MK-0571;MK-0679;MK-571;MK-679;MK571 cpd;verlukast;verlukast, (R-(E))-isomer
Molecular Weight	515.09

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