Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC 50 = 44 nM). Inhibits leukotriene biosynthesis (IC 50 = 2.5 nM) in vitro and tumor activity in vivo . Displays PPARα antagonist activity.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of Peroxisome proliferator-activated receptor-α
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Huang Y et al.. (2020) Resveratrol protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis via the PPARa pathway.. Appl Physiol Nutr Metab, 45 (3):(227-239). [PMID:31173696]
2.Tao T et al.. (2019) Role of adiponectin/peroxisome proliferator-activated receptor alpha signaling in human chorionic gonadotropin-induced estradiol synthesis in human luteinized granulosa cells.. Mol Cell Endocrinol, 493 (110450). [PMID:31116958]
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G2106177