Selective, cell-permeable, reversible, non-competitive Cdc42 GTPase inhibitor (IC 50 = 2.6 μM). Shows antiproliferative effects. Shows anticonvulsant effects in vivo.
ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inh
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Application
ML 141 has been used:
to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells
1.Kolyvushko O et al.. (2020) Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport.. Microorganisms, 8 (7):[PMID:32645930]
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L2108736