ML 141 - ≥98%, high purity , CAS No.71203-35-5

Item Number

M275404

• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: Selective, cell-permeable, reversible, non-competitive Cdc42 GTPase inhibitor (IC 50 = 2.6 μM). Shows antiproliferative effects. Shows anticonvulsant effects in vivo. ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inh
• Storage Temp: Store at -20°C,Desiccated
• Shipped In: Ice chest + Ice pads
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Application

ML 141 has been used:

to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells

as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei

as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria

as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells