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G protein-coupled receptors (GPCRs)
Bombesin receptors
ML 18 - ≥98%(HPLC), high purity , CAS No.1422269-30-4, Antagonist of BB 3 receptor

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ML 18 - ≥98%(HPLC), high purity , CAS No.1422269-30-4, Antagonist of BB 3 receptor

Moligand™

≥98%(HPLC)

CAS#: 1422269-30-4
Formula: C₃₂H₃₅N₅O₅
Molecular Weight: 569.65
PubChem CID: 91827363

Item Number

M288443

Grouped product items
SKU	Size	Availability	Price
M288443-5mg	5mg	In stock	$195.90
M288443-10mg	10mg	In stock	$271.90
M288443-25mg	25mg	In stock	$597.90
M288443-50mg	50mg	In stock	$1,033.90
M288443-100mg	100mg	In stock	$1,305.90

BRS-3 antagonist; also GRPR agonist

View related series

BB3 receptor Antagonist Bombesin Receptor GPCR/G Protein

Basic Description

Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Bombesin receptor subtype 3 (BRS-3) antagonist (IC50= 4.8μM). Also binds GRPR (IC50= 16μM). InhibitsBA1-stimulated cytosolic Ca2+and suppresses cell proliferation in a lung cancer modelin vitro.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of BB 3 receptor

Associated Targets(Human)

BRS3 Tchem Bombesin receptor subtype-3 (1 Activities)

Discover Target: BRS3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-3-(1H-indol-3-yl)-N-[[1-(4-methoxyphenyl)cyclohexyl]methyl]-2-[(4-nitrophenyl)carbamoylamino]propanamide
INCHI	InChI=1S/C32H35N5O5/c1-42-26-15-9-23(10-16-26)32(17-5-2-6-18-32)21-34-30(38)29(19-22-20-33-28-8-4-3-7-27(22)28)36-31(39)35-24-11-13-25(14-12-24)37(40)41/h3-4,7-16,20,29,33H,2,5-6,17-19,21H2,1H3,(H,34,38)(H2,35,36,39)/t29-/m0/s1
InChi Key	JOKVJNCYOSFDGC-LJAQVGFWSA-N
Canonical SMILES	COC1=CC=C(C=C1)C2(CCCCC2)CNC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)NC5=CC=C(C=C5)[N+](=O)[O-]
Isomeric SMILES	COC1=CC=C(C=C1)C2(CCCCC2)CNC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)NC5=CC=C(C=C5)[N+](=O)[O-]
PubChem CID	91827363
Molecular Weight	569.65

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
I2224530	Certificate of Analysis	Jul 21, 2022	M288443
I2224531	Certificate of Analysis	Jul 21, 2022	M288443
I2224532	Certificate of Analysis	Jul 21, 2022	M288443
I2224533	Certificate of Analysis	Jul 21, 2022	M288443
I2224534	Certificate of Analysis	Jul 21, 2022	M288443

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 56.97, Max Conc. mM: 100

References

1. Moody TW, Mantey SA, Moreno P, Nakamura T, Lacivita E, Leopoldo M, Jensen RT. (2015) ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth.. Peptides, 64 (13): (55-61). [PMID:25554218] [10.1021/op500134e]

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