ML 265 - 98%, high purity , CAS No.1221186-53-3, Activator of pyruvate kinase M1/2

Item Number
M333473
Grouped product items
SKUSizeAvailabilityPrice Qty
M333473-5mg
5mg
In stock
$117.90
M333473-10mg
10mg
In stock
$177.90
M333473-25mg
25mg
In stock
$400.90
M333473-50mg
50mg
In stock
$533.90
M333473-100mg
100mg
In stock
$771.90

an activator of PKM2.

Basic Description

SynonymsAS-16621 | CS-4865 | MLS006010294 | A901578 | [6-(3-Aminobenzyl)-4-methyl-5-oxo-5,6-dihydro-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-2-yl](methyl)sulfoniumolate | DB01996 | FT-0663861 | 2-METHYLPYRIDINE [HSDB] | 4-methyl morpholine | ML265 | ML-265 | S
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR
Mechanism of actionActivator of pyruvate kinase M1/2

Associated Targets(Human)

PKM Tchem Pyruvate kinase PKM (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-126 (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW480 (6023 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-251 (51189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-87 MG (3946 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-118-MG (352 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pklr Pyruvate kinase isozymes R/L (113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C6 (2371 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NIH3T3 (5395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488200983
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488200983
IUPAC Name 10-[(3-aminophenyl)methyl]-7-methyl-4-methylsulfinyl-3-thia-7,10,11-triazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),4,11-tetraen-9-one
INCHI InChI=1S/C17H16N4O2S2/c1-20-13-7-14(25(2)23)24-16(13)12-8-19-21(17(22)15(12)20)9-10-4-3-5-11(18)6-10/h3-8H,9,18H2,1-2H3
InChi Key ZWKJWVSEDISQIS-UHFFFAOYSA-N
Canonical SMILES CN1C2=C(C3=C1C(=O)N(N=C3)CC4=CC(=CC=C4)N)SC(=C2)S(=O)C
Isomeric SMILES CN1C2=C(C3=C1C(=O)N(N=C3)CC4=CC(=CC=C4)N)SC(=C2)S(=O)C
PubChem CID 44246499
Molecular Weight 372.5

Certificates

Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
D2312462Certificate of AnalysisFeb 28, 2023 M333473
D2312464Certificate of AnalysisFeb 28, 2023 M333473
D2312465Certificate of AnalysisFeb 28, 2023 M333473
D2312467Certificate of AnalysisFeb 28, 2023 M333473
D2312468Certificate of AnalysisFeb 28, 2023 M333473
D2312469Certificate of AnalysisFeb 28, 2023 M333473
D2312470Certificate of AnalysisFeb 28, 2023 M333473
D2312471Certificate of AnalysisFeb 28, 2023 M333473
D2312472Certificate of AnalysisFeb 28, 2023 M333473
D2312552Certificate of AnalysisFeb 28, 2023 M333473

Chemical and Physical Properties

SolubilitySoluble in DMSO (~10 mg/ml).
Refractive Indexn20D1.81 (Predicted)
Boil Point(°C)~711.6° C at 760 mmHg (Predicted)

Related Documents

References

1. Fan F, Wood KV.  (2007)  Bioluminescent assays for high-throughput screening..  Assay Drug Dev Technol,  (1): (127-36).  [PMID:17355205] [10.1021/op500134e]
2. Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW et al..  (2010)  Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase..  Bioorg Med Chem Lett,  20  (11): (3387-93).  [PMID:20451379] [10.1021/op500134e]
3. Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A et al..  (2012)  Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis..  Nat Chem Biol,  (10): (839-47).  [PMID:22922757] [10.1021/op500134e]
4. Jiang J, Walsh MJ, Brimacombe KR, Anastasiou D, Yu Y, Israelsen WJ, Hong BS, Tempel W, Dimov S, Veith H et al..  (2010)  ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model.  Probe Reports from the NIH Molecular Libraries Program,  71  (13): (1755-70).  [PMID:23905203] [10.1021/op500134e]
5. Angiari S, Runtsch MC, Sutton CE, Palsson-McDermott EM, Kelly B, Rana N, Kane H, Papadopoulou G, Pearce EL, Mills KHG et al..  (2020)  Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity..  Cell Metab,  31  (2): (391-405.e8).  [PMID:31761564] [10.1016/j.cmet.2019.10.015]

Solution Calculators